Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: Is there a link?

Targher, Giovanni; Chonchol, Michel; Zoppini, Giacomo; Abaterusso, Cataldo; Bonora, Enzo

doi:10.1016/j.jhep.2010.11.007

Cited by 163 publications

(145 citation statements)

References 79 publications

Supporting

Mentioning

136

Contrasting

Unclassified

Order By: Relevance

“…6 Furthermore, NAFLD appears to be an independent cardiovascular risk factor 7 and is also implicated in the pathogenesis of the metabolic syndrome. 2 The pathogenesis of NAFLD, of its related morbidities and of its progression to NASH remains poorly understood.…”

mentioning

confidence: 99%

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture

Francque

Laleman²,

Verbeke³

et al. 2012

Laboratory Investigation

109

124

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease can progress to steatohepatitis and fibrosis, and is also associated with impaired liver regeneration. The pathophysiology remains elusive. We recently showed that severe steatosis is associated with an increase in portal pressure, suggesting liver flow impairment. The objective of this study is to directly assess total intrahepatic resistance and its potential functional and structural determinants in an in situ perfusion model. Male Wistar rats fed a control (n ¼ 30) or a methionine-choline-deficient (MCD) diet (n ¼ 30) for 4 weeks were compared. Liver tissue and serum analysis, in vivo haemodynamic measurements, in situ perfusion experiments and vascular corrosion casts were performed. The MCD group showed severe steatosis without inflammation or fibrosis on histology. Serum levels and liver tissue gene expression of interleukin (IL)-6, tumour necrosis factor-a, IL-1b and interferon-g, liver tissue myeloperoxidase activity and liver immunohistochemistry with anti-CD68 and anti-a smooth muscle actin were comparable between groups, excluding significant inflammation. Flow-pressure curves were significantly different between groups for all flows (slope values: 0.1636±0.0605 mm Hg/ml/min in controls vs 0.7270±0.0408 mm Hg/ml/min in MCD-fed rats, Po0.001), indicating an increased intrahepatic resistance, which was haemodynamically significant (portocaval pressure gradient 2.2 ± 1.1 vs 8.2 ± 1.3 mm Hg in controls vs MCD, Po0.001). Dose-response curves to acetylcholine were significantly reduced in MCD-fed rats (Po0.001) as was the responsiveness to methoxamine (Po0.001). Vascular corrosion casts showed a replacement of the regular sinusoidal anatomy by a disorganized pattern with multiple interconnections and vascular extensions. Liver phosphorylated endothelial NO synthase (eNOS)/eNOS and serum nitrite/nitrate were not increased in severe steatosis, whereas liver thromboxane synthase expression, liver endothelin-1 (ET-1) expression and serum andothelin-1 concentration were significantly increased. Severe steatosis induces a haemodynamically significant increase in intrahepatic resistance, which precedes inflammation and fibrogenesis. Both functional (endothelial dysfunction and increased thromboxane and ET-1 synthesis) and structural factors are involved. This phenomenon might significantly contribute to steatosis-related disease.

show abstract

mentioning

confidence: 99%

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture

Francque

Laleman²,

Verbeke³

et al. 2012

Laboratory Investigation

109

124

View full text Add to dashboard Cite

show abstract

“…23,24 Pro-inflammatory cytokines from adipose tissue may be the link between NAFLD and extrahepatic comorbidity. [22][23][24][25] The intense metabolic crosstalk between dysfunctional visceral adipose tissue and the liver causes a pro-inflammatory condition, with a greater release of free fatty acids and cytokines, hepatic and peripheral insulin resistance, and the reduction of anti-inflammatory cytokines such as adiponectin. The liver as such is a source of oxidative stress, hypercoagulability, hypofibrinolysis, and atherogenic dyslipidemia.…”

Section: Discussionmentioning

confidence: 99%

Female Dietary Patterns and the Pathogenesis of NAFLD

Hörist-Kollmann¹,

Strametz-Juranek²

2018

Gender and the Genome

View full text Add to dashboard Cite

In Europe as well as the United States, nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease and is strongly associated with obesity and type 2 diabetes mellitus (T2DM). Nonalcoholic fatty liver disease is defined as a hepatic manifestation of the metabolic syndrome. Being a very powerful and independent cardiovascular risk factor, NAFLD increases cardiovascular and overall mortality to a significant degree. The purpose of this review was to determine sex-and gender-specific differences in the prevalence and pathogenesis of NAFLD and delineate the specific characteristics of NAFLD as a systemic disease in men and women. Postmenopausal women and women with endocrine disorders such as the polycystic ovarian syndrome are at high risk of developing NAFLD. The increasing incidence of female NAFLD after menopause appears to be related to reduced estrogen and increased testosterone levels, as well as changes in the distribution of fatty tissue. Finally, the role of genderspecific nutrition patterns in the pathogenesis of NAFLD will be discussed. Fructose consumption from industrialized products is a promoter of NAFLD, depending on the total daily calorie intake of macronutrients. A higher level of health literacy and conscious food behavior have been noted among women of all age groups compared to males, which could play a role in the pathogenesis of NAFLD. Health professionals are confronted with the challenges of early diagnosis by the use of sensitive, reliable, and noninvasive diagnostic tools, including screening algorithms for high-risk persons and providing gender-specific nutritional support as a crucial element of treatment and disease prevention.Keywords NAFLD and women, prevalence and epidemiology of NAFLD, gender nutrition patterns, and fructose and NAFLD

show abstract

“…lipid-lowering, weight-reducing, antihypertensive and hypoglycemic) being more appropriate for NAFLD patients 73,74 . Interestingly, NAFLD has been associated with increased CKD incidence 75 . Additionally, lower eGFR correlated with increased transaminases and more severe NAFLD 76 .…”

Section: I a L D I S T R I B U T I O N U N A U T H O R I Z E D U S mentioning

confidence: 99%

Multifactorial treatment for improvement of renal function and cardiovascular risk: an ATTEMPT for patients with metabolic syndrome and chronic kidney disease

Katsiki

Elisaf

2011

Current Medical Research and Opinion

View full text Add to dashboard Cite

Risk of chronic kidney disease in patients with non-alcoholic fatty liver disease: Is there a link?

Cited by 163 publications

References 79 publications

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture

Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture

Female Dietary Patterns and the Pathogenesis of NAFLD

Multifactorial treatment for improvement of renal function and cardiovascular risk: an ATTEMPT for patients with metabolic syndrome and chronic kidney disease

Contact Info

Product

Resources

About