Risk of childhood asthma following prenatal exposure to negative life events and job stressors: A
                    nationwide register-based study in Denmark

Liu, Xiaoqin; Madsen, Kathrine Pape; Sejbæk, Camilla Sandal; Kolstad, Henrik Albert; Bonde, Jens Peter; Olsen, Jørn; Hougaard, Karin Sørig; Hansen, Kirsten; Andersson, Niklas Worm; Rugulies, Reiner; Schlünssen, Vivi

doi:10.5271/sjweh.3785

Cited by 9 publications

(38 citation statements)

References 34 publications

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“…Of these, 273 articles were left for full-text screening and 264 were excluded because of not accessible (n=10), study aim/design (n=54), population (n=100), outcome (n=28), intervention (n=63), animal (n=9). Since no additional records identi ed through other sources, giving a total of 9 observational studies entered our nal model [10,12,13,[18][19][20][21][22][23].…”

Section: Discussionmentioning

confidence: 99%

“…Characteristics of the included studies Table 1 presents the included studies [10,12,13,[18][19][20][21][22][23]. There were 4 prospective cohort studies [7,[18][19][20], 4 retrospective cohort studies [12,13,21,22] [11,13,21,22] and 1 case-control study [23]. The majority of included studies came from Europe, and the rest of them were from America.…”

Section: Study Selectionmentioning

confidence: 99%

“…The included studies investigated based on different exposure including depression, anxiety, depression or anxiety, mental health service use, prenatal postpartum distress, and negative life events. Studies were grouped into the categories according to their outcomes which had 5 asthma [10,12,13,18,21], 3 AD [19,20,23], and 1 asthma and AD [22]. To ensure the reliability and quality control of this metaanalysis, we scored each of the included studies by using NOS criteria, studies with more than ve stars can be included in the research.…”

Section: Study Selectionmentioning

confidence: 99%

“…To ensure the reliability and quality control of this metaanalysis, we scored each of the included studies by using NOS criteria, studies with more than ve stars can be included in the research. After evaluation, there were 6 studies scored 9 [10,12,18,20,22,23], and 3 studies scored 8 [13,19,21] (Supplementary Table 1a). The outcome of Letourneau et al, 2017 was measured when the infants were only 18-months old which contribute to an insu cient follow-up period for outcome occurrence [19].…”

Section: Study Selectionmentioning

confidence: 99%

“…The evidence was limited to fewer literatures on researching the in uences of offspring asthma was made by father mental disorder than postnatal depression in mothers. Besides that, there has a new study was published in 2019 reported maternal mental disorder isn't associated with offspring asthma signi cantly, whereas low job control shows a more relevant risk factor [13]. Despite the association was signi cant, the odds of environmental effects on the periods between delivery and diagnose of asthma or AD still cannot be ignored.…”

Section: Introductionmentioning

confidence: 99%

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Does Prenatal Anxiety or Depression Symptoms Associate With Asthma or Atopic Diseases Throughout the Offspring's Childhood? An Updated Systematic Review and Meta-analysis

Chen

2020

Preprint

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Background:Asthma is the most common respiratory disease among children, while atopic disease such as atopic dermatitis affects about 20% infants under 2 years old. Recently, the investigators found that they may all be related to prenatal depression or anxiety, but further research and analysis are needed. This study aimed to explore the association between prenatal psychiatric disorder and childhood asthma or atopic disease in a systematic review and meta-analysis of nine studies. Methods:We searched PubMed, Embase, and Cochrane library up to May 2020. The primary outcome was the childhood asthma and childhood atopic dermatitis. We used random-effects model because of high heterogeneity indicated by I2 >50% and P<0.10. Results:A total of 598 studies were initially entered the PRISMA flow process, after selection, there had 9 studies met our inclusion criteria. Prenatal mental disorder is associated with childhood asthma (ES=1.146, 95%CI: 1.054-1.245, P=0.001; I2=93.5%, Pheterogeneity<0.001) whereas no statistically significant had been found on childhood atopic dermatitis (ES=1.211, 95%CI: 0.982-1.494, P=0.073; I2=78.5%, Pheterogeneity<0.001). The childhood asthma seems to be related more to depression (ES=1.170, 95%CI: 1.061-1.291, P=0.002) and anxiety/depression (ES=1.157, 95%CI: 1.050-1.275, P=0.073; I2=95.3%, Pheterogeneity<0.001). Conclusion:This present meta-analysis demonstrated that prenatal mental disorder increased the risk of childhood asthma. We limited the included samples to pregnant women to investigate the association between prenatal psychological factors and offspring’s physical health. Future study should include large high-quality cohort studies to investigate behavior, environmental and genetic causes for this association

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Section: Discussionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Study Selectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Does Prenatal Anxiety or Depression Symptoms Associate With Asthma or Atopic Diseases Throughout the Offspring's Childhood? An Updated Systematic Review and Meta-analysis

Chen

2020

Preprint

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Genetic liability to major depression and risk of childhood asthma

Liu

Munk‐Olsen

Albiñana

et al. 2020

Brain, Behavior, and Immunity

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Parental occupational exposure pre- and post-conception and development of asthma in offspring

Pape

Sejbæk

Malinovschi

et al. 2020

International Journal of Epidemiology

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Background While direct effects of occupational exposures on an individual’s respiratory health are evident, a new paradigm is emerging on the possible effects of pre-conception occupational exposure on respiratory health in offspring. We aimed to study the association between parental occupational exposure starting before conception and asthma in their offspring (at 0–15 years of age). Methods We studied 3985 offspring participating in the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Their mothers or fathers (n = 2931) previously participated in the European Community Respiratory Health Survey (ECRHS). Information was obtained from questionnaires on parental job history pre- and post-conception which was linked to an asthma-specific job-exposure matrix (JEM). We assessed the association between parental occupational exposure and offspring asthma, applying logistic regression models, clustered by family and adjusted for study centre, offspring sex, parental characteristics (age, asthma onset, place of upbringing, smoking) and grandparents’ level of education. Results Parental occupational exposure to microorganisms, pesticides, allergens or reactive chemicals pre-conception or both pre- and post-conception was not related to offspring asthma; in general, subgroup analyses confirmed this result. However, maternal exposure both pre- and post-conception to allergens and reactive chemicals was associated with increased odds for early-onset asthma in offspring (0–3 years of age); odds ratio 1.70 (95% CI: 1.02–2.84) and 1.65 (95% CI: 0.98–2.77), respectively. Conclusions This study did not find evidence that parental occupational exposure, defined by an asthma JEM before conception only or during pre- and post-conception vs non-exposed, was associated with offspring asthma.

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Risk of childhood asthma following prenatal exposure to negative life events and job stressors: A nationwide register-based study in Denmark

Cited by 9 publications

References 34 publications

Does Prenatal Anxiety or Depression Symptoms Associate With Asthma or Atopic Diseases Throughout the Offspring's Childhood? An Updated Systematic Review and Meta-analysis

Does Prenatal Anxiety or Depression Symptoms Associate With Asthma or Atopic Diseases Throughout the Offspring's Childhood? An Updated Systematic Review and Meta-analysis

Genetic liability to major depression and risk of childhood asthma

Parental occupational exposure pre- and post-conception and development of asthma in offspring

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