Risk of Cardiovascular Disease Associated with a Restless Legs Syndrome Diagnosis in a Retrospective Cohort Study from Kaiser Permanente Northern California

Eeden, Stephen K. Van Den; Albers, Kathleen; Davidson, Julie; Kushida, Clete A.; Leimpeter, Amethyst; Nelson, Lorene M.; Popat, Rita A.; Tanner, Caroline M.; Bibeau, Kristen; Quesenberry, Charles P.

doi:10.5665/sleep.4800

Cited by 63 publications

(51 citation statements)

References 22 publications

(30 reference statements)

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“…RLS has been associated with hypertension (HTN), coronary vascular diseases (CVD), insomnia (initiation and maintenance insomnia), depression and fatigability [9,10]. Insomnia has been related to HTN, fatigability, depression and poor performance in work [11].…”

Section: Introductionmentioning

confidence: 99%

Poor Knowledge and Attitude Regarding Obstructive Sleep Apnea (OSA) Among Medical Students in India: A Call for MBBS Curriculum Change

2017

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Context and AimsSleep disorders are one of the most common disorders but are not given enough importance in medical teaching. This study was done to find the knowledge of medical students about the most common sleep disorders. Design Cross-sectional study. Methods and Materials A total of 232 final-year medical students from four medical colleges filled up OSAKA and OSAKAkids questionnaire. Statistical Analysis Used Demographic variables were summarized by descriptive statistic measures like counts and percentages. Continuous variables like knowledge scores were summarized as mean and standard deviation. Knowledge scores and perceived importance were compared using t test; p value less than 0.05 was considered as statistically significant. Results Knowledge score of students for OSAKA adults and OSAKA-kids questionnaire was 37.93 ± 16.31 and 42.1 ± 20.27%. 91.47, and 86.21% of students rated OSA in adults and kids, respectively, as important to extremely important clinical disorder. Conclusions Although majority of medical students think OSA is significant medical disorder, their knowledge regarding OSA is very poor. Dedicated sleep medicine training covering main sleep disorders should be done in all medical colleges.

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Section: Introductionmentioning

confidence: 99%

Poor Knowledge and Attitude Regarding Obstructive Sleep Apnea (OSA) Among Medical Students in India: A Call for MBBS Curriculum Change

2017

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“…These results suggest that the increased risk of CVD in secondary RLS is due to the underlying comorbidities but not RLS independently. 2 Another study of 5,000 women found an association of RLS with self-reported comorbid heart disease (aOR =2.13; 95%CI, 1.18-3.86). 24 On the other hand, Koo et al found only a weak association of PLM arousal index ≥5/h with all-cause CVD (HR =1.26; 95%CI, 1.01-1.57; P trend 0.0402) but not with CAD or CHD specifically.…”

Section: Rls/plms and Cardiovascular Diseasesmentioning

confidence: 99%

“…2 Other reported conditions where RLS occurs more frequently include narcolepsy, OSA, PD, MS, rheumatoid arthritis, and other conditions. 2,9 CKD and end-stage renal disease (ESRD) are well known to be associated with CVD. The prevalence of RLS in ESRD varies greatly according to different studies and regions.…”

Section: Secondary Rls/plms and Risk Of Cardiovascular Diseasementioning

confidence: 99%

“…17 Other subclassifications describe RLS as primary (idiopathic) or secondary RLS when it is associated with pregnancy, iron deficiency anemia (IDA), chronic renal failure, or other conditions. 2 The exact pathophysiology of RLS remains unclear. Various mechanisms including (individually or in combination) genetic predisposition, dopaminergic dysfunction, brain iron insufficiency, activation of hypoxic pathways, glutamatergic system involvement, opioid system dysfunction, and a few others have been proposed.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, in subsequent analysis, when secondary RLS and control group were matched for comorbidities (anemia and/or renal disease), the risk of hypertension moves to a null value. 2 In a rural community in Shanghai (N=2,941), hypertension was associated with RLS (aOR =4.10; 95% CI, 1.88-8.92; P<0.001). Interestingly, when compared by gender, hypertension was a risk factor for RLS in males but not in females in this study.…”

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confidence: 99%

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Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

Vargas-Pérez¹,

Bagai²,

Walters³

2017

JPRLS

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Increased Blood Pressure Dipping in Restless Legs Syndrome With Rotigotine: A Randomized Trial

et al. 2020

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The objective of this study was to assess the rotigotine effect on the nocturnal blood pressure (BP) dip by 24-hour ambulatory BP monitoring and on endothelial function in patients with restless legs syndrome (RLS) compared with placebo. Methods: In this double-blind, placebo-controlled trial, 76 adult patients with moderate to severe RLS and periodic legs movements in sleep index ≥10/hour were randomized to rotigotine at optimal dose of 3 mg per day or placebo for 6 weeks. A total of 6 patients had a major protocol deviation. Polysomnography, ambulatory BP monitoring, and endothelial function were assessed at baseline and end point. The primary outcome was the between-group difference in the percentage of BP nondipper profiles at end point. The main secondary outcomes were the mean BP dip, periodic legs movements in sleep index, and endothelial function. Results: Of the 70 patients (age, 59.4 ± 11.40; 43 women) randomized to rotigotine (n = 34) and placebo (n = 36), 66 (33 rotigotine, 33 placebo) completed the study. The percentage of BP nondippers at end point was higher in the placebo than in the rotigotine group (systolic BP, 72.22% vs 47.06%; diastolic BP, 47.22% vs 20.59%; P < 0.05). Mean BP dip at end point was higher in the rotigotine than in the placebo group (systolic BP, 11.24 ± 6.15 vs 6.12 ± 7.98; diastolic BP, 15.12 ± 7.09 vs 9.36 ± 10.23; P < 0.05). Endothelial function was comparable between the groups. No significant safety concerns were reported with similar incidences of adverse events between groups. Conclusion: Rotigotine increased the percentage of BP dipper profiles and the BP dip in patients with RLS. Future studies should assess whether this change is associated with a reduction in the long-term cardiovascular risk in RLS.

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Risk of Cardiovascular Disease Associated with a Restless Legs Syndrome Diagnosis in a Retrospective Cohort Study from Kaiser Permanente Northern California

Cited by 63 publications

References 22 publications

Poor Knowledge and Attitude Regarding Obstructive Sleep Apnea (OSA) Among Medical Students in India: A Call for MBBS Curriculum Change

Poor Knowledge and Attitude Regarding Obstructive Sleep Apnea (OSA) Among Medical Students in India: A Call for MBBS Curriculum Change

Cardiovascular comorbidity in patients with restless legs syndrome: current perspectives

Increased Blood Pressure Dipping in Restless Legs Syndrome With Rotigotine: A Randomized Trial

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