Risk of cancer in patients with irritable bowel syndrome: a nationwide population-based study

Hu, Li; Ku, Fan Chen; Lu, Tung‐Wu; Shen, Cheng; Hu, Yu; Yeh, Chiu Mei; Tzeng, Cheng Hwai; Chen, Tzeng Ji; Chen, Pan Ming; Liu, Chia Jen

doi:10.1016/j.annepidem.2015.07.006

Cited by 13 publications

(20 citation statements)

References 38 publications

(41 reference statements)

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“…It contains comprehensive information regarding ambulatory and inpatient care, dental services, Chinese medicine, maternity services, physical and occupational rehabilitation, chronic mental illness care, and immunization. Research based on the NHI database provides valuable data regarding cancer diagnosis, epidemiology, outcome, and treatment …”

Section: Introductionmentioning

confidence: 99%

Validity of cancer diagnosis in the National Health Insurance database compared with the linked National Cancer Registry in Taiwan

Kao

Hong

See

et al. 2017

Pharmacoepidemiology and Drug

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Section: Introductionmentioning

confidence: 99%

Validity of cancer diagnosis in the National Health Insurance database compared with the linked National Cancer Registry in Taiwan

Kao

Hong

See

et al. 2017

Pharmacoepidemiology and Drug

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“…Irritable bowel syndrome (IBS) is a functional bowel disorder characterised by chronic or recurrent abdominal pain associated with either relief or exacerbation by defecation, or a change in bowel habit . The consequences of IBS include the risk of other disorders or diseases, such as colorectal neoplasia, colorectal cancer, and other cancers, and asthma …”

Section: Introductionmentioning

confidence: 99%

Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study

et al. 2018

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“…Of the 1,364 publications initially searched from PubMed, Embase, and Web of Science databases and the additional 13 articles identified through manual review of the bibliography, six studies comprising 1,085,024 participants met the eligibility criteria to be included for analysis (18,19,(22)(23)(24)(25). The detailed process of study selection and reasons for exclusion are presented in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…The included studies were conducted in three regions: China ( 18 , 24 , 25 ), the United Kingdom ( 22 , 23 ), and Denmark ( 19 ). All included studies were population-based cohort studies with sample sizes ranging from 39,384 to 659,757.…”

Section: Resultsmentioning

confidence: 99%

Risk of Colorectal Cancer in Patients With Irritable Bowel Syndrome: A Meta-Analysis of Population-Based Observational Studies

Wang

et al. 2022

Front. Med.

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Background and AimsEvidence on the association between irritable bowel syndrome (IBS) and colorectal cancer (CRC) risk is inconsistent. Therefore, we aimed to examine whether IBS leads to an increased risk for CRC using a systematic review and meta-analysis approach.MethodsPubMed, Embase, and Web of Science were systematically searched to identify all relevant literature published through July 30, 2021. The pooled risk ratios (RRs) and corresponding 95% confidence intervals (CIs) for CRC after diagnosis of IBS were computed using random-and fixed-effects models and stratified by age, follow-up time, gender, and study design. The quality of included studies was assessed by the Newcastle-Ottawa scale.ResultsWe included six studies consisting of 1,085,024 participants. Overall, the risk of detecting CRC after the initial IBS diagnosis was significantly higher than non-IBS controls (RR = 1.52, 95% CI: 1.04–2.22, P = 0.032). The peak of elevated risk occurred within the first year of IBS diagnosis (RR = 6.84, 95% CI: 3.70–12.65, P < 0.001), and after 1 year, the risk of CRC was similar to that of the general population (RR = 1.02, 95% CI: 0.88–1.18, P = 0.813). Notably, we found that the RR of CRC was more significant in IBS patients younger than 50 years compared to those older than 50 years (RR = 2.03, 95% CI: 1.17-3.53, P = 0.012 vs. 1.28, 95%CI: 0.94-1.75, P = 0.118, respectively). Gender and study design did not affect the results.ConclusionThe risk of CRC within one year of the initial IBS diagnosis was increased approximately six-fold, whereas the long-term risk was not increased. However, current evidence does not support that IBS leads to an increased incidence of CRC, and the early excess risk is more likely attributable to misclassification resulting from overlapping symptoms rather than causation. Clinicians must remain vigilant for the CRC risk in patients younger than 50 years with IBS-like symptoms to avoid delaying necessary screening.

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Risk of cancer in patients with irritable bowel syndrome: a nationwide population-based study

Cited by 13 publications

References 38 publications

Validity of cancer diagnosis in the National Health Insurance database compared with the linked National Cancer Registry in Taiwan

Validity of cancer diagnosis in the National Health Insurance database compared with the linked National Cancer Registry in Taiwan

Risk of psychiatric disorders in irritable bowel syndrome-A nationwide, population-based, cohort study

Risk of Colorectal Cancer in Patients With Irritable Bowel Syndrome: A Meta-Analysis of Population-Based Observational Studies

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