Risk of cancer in infertile women: analysis of US claims data

Murugappan, Gayathree; Li, Shufeng; Lathi, Ruth B.; Baker, Valerie L.

doi:10.1093/humrep/dez018

Cited by 35 publications

(31 citation statements)

References 38 publications

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“…Overall, nine studies were finally included in the meta-analysis. [14][15][16][17][18][19][20][21][22]…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, the findings of cohort studies have been conflicting [14][15][16][17][18][19][20][21][22] during the past decades. Some studies reported that infertility was associated with an elevated risk of OC 14,15,[17][18][19]22 while others showed no association. 16,20,21 To the best of our knowledge, there has been no study comprehensively quantifying the evidence of infertility and OC risk.…”

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confidence: 99%

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Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies

Jiang

Gong

Zhang

et al. 2020

Intl Journal of Cancer

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Epidemiological studies have investigated the relationship between infertility and the risk of ovarian cancer (OC); however, the results have been inconsistent. We therefore conducted the first meta‐analysis to update and quantify the aforementioned association based on prospective cohort studies. Studies were identified by searching PubMed, EMBASE and Web of Science databases up to January 8, 2020. We extracted data from the studies and performed quality assessments. Summary relative risks (RRs) with 95% confidence intervals (CIs) were calculated using a random‐effects model. Publication bias, and subgroup, meta‐regression and sensitivity analyses were also conducted. Nine prospective cohort studies with a total of 10 383 OC cases and 6 278 830 participants were included in the present study. The summary RR of the association between infertility and the risk of OC was 1.51 (95% CI: 1.35‐1.69), with low heterogeneity. Positive associations were observed in most subgroup analyses stratified by predefined factors, including region, duration of follow‐up, study quality, causes of infertility, invasiveness of OC, infertility treatment status and adjustment of potential confounding parameters. No significant publication bias was detected. Our findings suggest that infertility in women were associated with an increased risk of OC.

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“…Overall, nine studies were finally included in the meta-analysis. [14][15][16][17][18][19][20][21][22]…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies

Jiang

Gong

Zhang

et al. 2020

Intl Journal of Cancer

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“…Alternative sources of MAR exposure include clinical quality registries of MAR that exist in most countries [4], including the Australian and New Zealand Assisted Reproductive Technology Database, ANZARD [10], ICD codes describing hospital encounter for MAR treatment (e.g. ICD-10-CM Diagnosis Code Z31.83), health insurance claims data [11], and birth registrations of children born following MAR [12]. ANZARD was not used in this concept because ART cycles were not linked to individual women in ANZARD until 2009.…”

Section: Analytical Approachmentioning

confidence: 99%

Parity: A key measure of confounding in data-linkage studies of outcomes after medically assisted reproduction

Chambers

Venetis

Jorm

et al. 2020

IJPDS

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Parity is a potential confounder of the association between medically assisted reproduction (MAR) and health outcomes. This concept paper describes a population-based record linkage study design for selecting MAR-unexposed women matched to the parity of MAR-exposed women, at the time of the first exposure to MAR. Women exposed to MAR were identified from claims for government subsidies for relevant procedures and prescription medicines, linked to perinatal records. Women unexposed to MAR were identified from linked perinatal and death records, matched to exposed women by age, rurality, age of first child (if any) and parity at the date of first MAR. The availability of a longitudinal, whole-of-population dataset ("population spine") based on enrolments in Australia's universal health insurance scheme was a critical design element. The example application examines cancer risk in women after exposure to MAR. Parity is a confounder in this setting because it is associated with MAR and hormone-sensitive cancers.

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“…Finally, epigenetic modifications in terms of alterations in the DNA methylation pattern and chromatin remodeling have been associated with development of endometriosis and EAOC; several groups have elaborated upon this issue [137,178,225,226]. Additionally, it will be of interest to understand the basis of the greater risk of gynecological cancers among infertile women affected by endometriosis [85,227,228]. It is important that the impact of heterogeneities at level of tissue, disease and histotypes, and other context-specific determinants are considered with due weightage while undertaking such studies in the future [229].…”

Section: Potential Involvement Of Mirnamentioning

confidence: 99%

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

Ghosh

Anupa

et al. 2019

COGO

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Endometriosis is an inflammatory disease characterized by the presence of endometrium-like tissue outside the uterus primarily on pelvic organs and tissues. It affects up to 15% of women in the reproductive age group and is often associated with pelvic pain and subfertility. Different theories explain how retrograde menstruation gives rise to endometrial deposits at ectopic sites, and how several other factors are involved in the progression of the disease. Its final diagnosis is established through direct visualization at laparoscopy or surgery followed by histological confirmation. Available epidemiological reports along with histopathological observations and molecular studies shed interesting light on the pathogenetic basis of different variants of the disease like deep infiltrating endometriosis and ovarian endometriosis. Evidence also suggests that endometriosis is a neoplastic condition which serves as a precursor of ovarian and endometrial cancers. In the present review, we have attempted to take a stock of the current epidemiological and molecular knowledge regarding endometriosis associated cancers and develop a model of functional network with interactions among critical genomic factors regulating cellular processes leading to fibrotic reaction. It is being conjectured that cyclic bleeding associated with inflammatory and oxidative stress followed by repeated tissue injury and repair along with recurrent estrogenic stimulation and ovulatory events in the pelvic environment bring about the complex phenotype of atypical endometriosis and associated neoplasm with a trade-off malignant transformation in high risk population. Finally, we have presented an algorithm for pre-emptive monitoring and management of endometriosis-associated cancers.

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Risk of cancer in infertile women: analysis of US claims data

Cited by 35 publications

References 38 publications

Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies

Infertility and ovarian cancer risk: Evidence from nine prospective cohort studies

Parity: A key measure of confounding in data-linkage studies of outcomes after medically assisted reproduction

How Benign is Endometriosis: Multi-Scale Interrogation of Documented Evidence

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