Risk of Cancer as a Result of Community Exposure to Gasoline Vapors

Patel, Ami; Talbott, Evelyn O.; Zborowski, Jeanne V.; Rycheck, Juley A; Dell, Danielle; Xu, Xiaohui; Schwerha, Joseph J.

doi:10.1080/00039890409605165

Cited by 23 publications

(10 citation statements)

References 27 publications

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“…Although epidemiologic studies in adults show clear evidence of causal relationship between benzene exposure and certain leukemias [21,22], benzene induced carcinogenicity in children has not been clearly demonstrated [23][24][25]. Multiple factors could be responsible for potential health risks among children following their exposure to benzene.…”

Section: Discussionmentioning

confidence: 98%

Health Effects of Benzene Exposure among Children Following a Flaring Incident at the British Petroleum Refinery in Texas City

D’Andrea¹,

Reddy²

2013

Pediatric Hematology and Oncology

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Human exposure to benzene is associated with multiple adverse health effects leading to hematological malignancies. The objective of this retrospective study was to evaluate the health consequences of benzene exposure in children following a flaring incident at the British petroleum (BP) refinery in Texas City, Texas. The study included children aged <17 years who had been exposed and unexposed to benzene. Using medical charts, clinical data including white blood cell (WBC) counts, platelets counts, hemoglobin, hematocrit, blood urea nitrogen (BUN), creatinine, alkaline phosphatase (ALP), aspartate amino transferase (AST), alanine amino transferase (ALT), and somatic symptom complaints by the children exposed to benzene were reviewed and analyzed. A total of 312 subjects (benzene exposed, n = 157 and unexposed, n = 155) were included. Hematologic analysis showed that WBC counts were significantly decreased in benzene-exposed children compared with the unexposed children (6.8 ± 2.1 versus 7.3 ± 1.7, P = .022). Conversely, platelet (X 10(3) per μL) counts were increased significantly in the benzene-exposed group compared with the unexposed group (278.4 ± 59.9 versus 261.6 ± 51.7, P = .005). Similarly, benzene-exposed children had significantly higher levels of ALP (183.7± 95.6 versus 165 ± 70.3 IU/L, P = .04), AST (23.6 ± 15.3 versus 20.5 ± 5.5 IU/L, P = .015), and ALT (19.2 ± 7.8 versus 16.9 ± 6.9 IU/L, P = .005) compared with the unexposed children. Together, the results of the study reveal that children exposed to benzene experienced significantly altered blood profiles, liver enzymes, and somatic symptoms indicating that children exposed to benzene are at a higher risk of developing hepatic or blood related disorders.

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Section: Discussionmentioning

confidence: 98%

Health Effects of Benzene Exposure among Children Following a Flaring Incident at the British Petroleum Refinery in Texas City

D’Andrea¹,

Reddy²

2013

Pediatric Hematology and Oncology

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“…The most dangerous effects are due to benzene which is mostly found in petrochemical vapors. 1 Benzene (C6H6) is a clear, colorless, noncorrosive, volatile highly inflammable liquid. Its low boiling point and high vapor pressure causes rapid evaporation under ordinary atmospheric conditions.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Haematological Parameters among Petrol Pump Workers in Bhubaneswar

Mahapatra¹,

Pradhan²,

Patnaik³

2016

IJMRP

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Background and objectives: Petrochemical workers are exposed to many noxious substances present in their work places. The most dangerous effects are due to benzene which is mostly found in petrochemical vapors. It is a well known carcinogen with relative hematotoxicity. So in our study we have assessed the hematological parameters (i.e. absolute eosinophil count, hemoglobin concentration, platelet count) of petrol pump workers in and around Bhubaneswar. Methods: This study was conducted in the department of Physiology Hi-Tech medical college and hospital Bhubaneswar in 2016. Study group contains fifty petrol pump workers between age group of 20-50 years. Fifty healthy male nonsmokers housekeeping staff of Hi-Tech Medical College and Hospital matching socially and economically with study group were selected as controls. Absolute eosinophil count was done by using Pilots solution, Hemoglobin concentration estimation by Sahli's method and direct platelet count was done using Rees Eker's fluid. Result: When we compare AEC in subjects who are exposed to more than 10 years with that of controls, there is decrease in count which is statistically significant. In control group when duration of exposure is between 11-15 years mean Hb concentration is 13.88 with a SD of 0.457, when duration of exposure is >15 years mean ± SD of Hb concentration is 12.64 ± 0.58 and both of these findings are statistically significant. There was no significant difference in the platelet count of study and control group. Conclusion: In our study when the duration of exposure is more than 11 yrs the absolute eosinophil count was significantly decreased (p<0.005). When the duration of exposure is more than 15 years there occurs statistically decrease in hemoglobin count in study group. In conclusions those exposed to prolong benzene exposure may develop bone marrow depression as evidenced by decrease in hemoglobin concentration and absolute eosinophil counts. So the parameters like hemoglobin concentration, absolute eosinophil count may be useful in detection of early hematological changes among exposed workers.

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“…Soil and groundwater contamination is common at gas stations. Drinking water wells proximate to gas stations, which in rural areas are often the only drinking water source, can become contaminated, potentially exposing well users to benzene and other chemicals [48,49]. In addition, runoff from rain and other weather events can carry spilled hydrocarbons, which can contaminate surface waters; those using surface waters, either recreationally or for other purposes, may be exposed to these contaminants through dermal contact or incidental ingestion.…”

Section: Exposure and Risks To Human Populationsmentioning

confidence: 99%

Hydrocarbon Release During Fuel Storage and Transfer at Gas Stations: Environmental and Health Effects

Hilpert

Mora

et al. 2015

Curr Envir Health Rpt

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At gas stations, fuel is stored and transferred between tanker trucks, storage tanks, and vehicle tanks. During both storage and transfer, a small fraction of unburned fuel is typically released to the environment unless pollution prevention technology is used. While the fraction may be small, the cumulative release can be substantial because of the large quantities of fuel sold. The cumulative release of unburned fuel is a public health concern because gas stations are widely distributed in residential areas and because fuel contains toxic and carcinogenic chemicals. We review the pathways through which gasoline is chronically released to atmospheric, aqueous, and subsurface environments, and how these releases may adversely affect human health. Adoption of suitable pollution prevention technology should not only be based on equipment and maintenance cost but also on energy-and health care-saving benefits.

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Risk of Cancer as a Result of Community Exposure to Gasoline Vapors

Cited by 23 publications

References 27 publications

Health Effects of Benzene Exposure among Children Following a Flaring Incident at the British Petroleum Refinery in Texas City

Health Effects of Benzene Exposure among Children Following a Flaring Incident at the British Petroleum Refinery in Texas City

Assessment of Haematological Parameters among Petrol Pump Workers in Bhubaneswar

Hydrocarbon Release During Fuel Storage and Transfer at Gas Stations: Environmental and Health Effects

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