Risk of breast cancer associated with papilloma

Sakr, Rita A.; Rouzier, Roman; Salem, C.; Antoine, Martine; Chopier, J.; Daraı̈, Émile; Uzan, Serge

doi:10.1016/j.ejso.2008.03.013

Cited by 56 publications

(37 citation statements)

References 12 publications

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“…On the other hand, other researchers have supported selective excision in cases of atypia or in the presence of risk factors. [2][3][4]9,[13][14][15][16]18,[29][30][31][32][33] Table 4 shows the published data on papillomas confirmed by core needle biopsy and subsequent surgical excision and their upgrade rates to malignancy. These studies reported their rates of upgrade from benignity on core needle biopsy to malignancy and papilloma with atypia after surgical excision.…”

Section: Discussionmentioning

confidence: 99%

“…1,2,[4][5][6][7][8][9][10][11][12] Some recent investigators have suggested the use of selective surgical excision for benign papillomas without atypia after considering clinical and radiologic factors or supported conservative management. 4,7,[13][14][15][16][17][18] Prediction of clinical and radiologic factors associated with an upgrade to atypia or malignancy will be very helpful for both clinicians and radiologists.…”

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confidence: 99%

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Comparison of Sonographically Guided Core Needle Biopsy and Excision in Breast Papillomas

Sohn

2013

Journal of Ultrasound in Medicine

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Objectives The aim of this study was to evaluate the clinical factors and sonographic features of benign papillomas of the breast proven by sonographically guided 14‐gauge core needle biopsy and their upgrade or malignancy rate after sonographically guided vacuum‐assisted excision or surgical excision. Methods We reviewed the medical records of patients who underwent core needle biopsy from July 2005 to December 2011. We evaluated 39 benign papillomas without atypia in 34 patients. The papillomas were diagnosed by core needle biopsy and underwent surgical or vacuum‐assisted excision. After core needle biopsy, imaging‐histologic correlation was performed to determine concordance. The upgrade and malignancy rates were assessed after surgical or vacuum‐assisted excision, and associated clinical and radiologic factors, including patient age, lesion size, distance from the nipple, sonographic features, and American College of Radiology Breast Imaging Reporting and Data System (BI‐RADS) category were evaluated. Results Three lesions (7.7 %) among 39 papillomas were upgraded to papilloma with atypia after surgical excision. There was no malignancy after excision. The upgrade rates for BI‐RADS categories 3, 4a, 4b, and 4c were 0%, 6.9%, 0%, and 20%, respectively. There were no significant differences in the upgrade to papilloma with atypia in terms of the presence of symptoms, lesion size, distance from the nipple, BI‐RADS category, or imaging‐histologic correlation. Conclusions Prediction of papilloma with atypia, not malignancy, was challenging because there were no associated clinical or radiologic factors to predict papilloma with atypia before excision. However, there was no malignancy after excision. Therefore, intensive surveillance is preferable to immediate surgical excision for benign papillomas diagnosed on core needle biopsy.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Comparison of Sonographically Guided Core Needle Biopsy and Excision in Breast Papillomas

Sohn

2013

Journal of Ultrasound in Medicine

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“…However, preoperative differential diagnosis between intracystic papillary carcinomas vs. papillomas is very challenging even after needle biopsy, because of their nonspecific radiological characteristics, and subtle cytological and histological appearance. Hence, surgical excisional biopsy is recommended in the clinical management of these lesions, especially when associated with risk factors for malignancy, such as age (≥ 50 years) and the presence of microcalcifications [6][7][8]10]. A few papers have reported immunohistochemical techniques to be effective, but only in combination with other diagnostic techniques [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

“…Intracystic tumors of the breast include benign papillomas, which account for approximately 10% of benign breast tumors, as well as carcinomas in situ and carcinomas with invasion, which together account for less than 1% of malignant breast tumors [1][2][3][4][5][6][7]. Intracystic papillary carcinoma develops with a predilection for elderly women, who often present with a palpable mass and/or bloody nipple discharge [1,2,4].…”

Section: Introductionmentioning

confidence: 99%

A novel diagnostic method targeting genomic instability in intracystic tumors of the breast

et al. 2014

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“…The treatment of these B3 risk lesions is contradictional, there are authors who suggest a surgical excision [11,74], and others do not find this necessary, only in the case of papillary lesions [75]. The indication for the operations in this series was very similar, although the diagnosis of IP was not established by using CNB, but was raised with high suspicion with ductography performed for single duct discharge after previous mammographic and US examinations.…”

Section: Selective Ductectomy For the Diagnosis And Treatment Of Intrmentioning

confidence: 71%

Current issues in breast surgery

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Risk of breast cancer associated with papilloma

Cited by 56 publications

References 12 publications

Comparison of Sonographically Guided Core Needle Biopsy and Excision in Breast Papillomas

Comparison of Sonographically Guided Core Needle Biopsy and Excision in Breast Papillomas

A novel diagnostic method targeting genomic instability in intracystic tumors of the breast

Current issues in breast surgery

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