Risk of bipolar disorder among adolescents with allergic rhinitis: A nationwide longitudinal study

Chen, Mu Hong; Lan, Wen Hsuan; Hsu, Ju Wei; Huang, Kou‐Yuan; Li, Cheng Ta; Lin, Wei Chen; Chang, Wen Han; Chen, Tzeng Ji; Pan, Tai‐Long; Su, Tung Ping; Bai, Ya Mei

doi:10.1016/j.jpsychores.2015.08.009

Cited by 12 publications

(6 citation statements)

References 28 publications

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“…AR in early life is associated with depression later in life [18]. Moreover, bipolar disorder in later life [19] has also been associated with AR, with a possible immune link involving a likely immune causation.…”

Section: Ar and Depressionmentioning

confidence: 99%

“…AR is more prevalent in patients with major depression and those having family history of depressive disorder [15–17]. In adolescents, a pediatric diagnosis of AR is predictive of an adult diagnosis of major depression [18] or bipolar disorder [19]. Additionally, in Finnish twins a potentially shared genetic risk between allergic disorders and depressive symptoms has been described [20].…”

Section: Introductionmentioning

confidence: 99%

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Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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Opinion Statement A high proportion of suicides visit their medical provider in the month prior to death, but depression, suicidal thoughts, and substance use are seldom addressed. For the clinicians routinely treating a substantial patient population with allergic diseases, there are additional concerns, as allergy has been linked with both depression and suicidal behavior. While psychotropic medications may affect diagnosis of allergies, medications used to treat allergies impact mood and behavior. Thus, we present an overview of the overlap of allergic rhinitis with depression and suicidal behavior in adults, based on clinical and epidemiological data, and our research and clinical experience. In summary, we suggest: 1) inquiring among patients with allergies about personal and family history of depression, substance use disorders, suicidal ideation and attempts 2) increased mindfulness regarding the potential effects of allergy medications on mood and behavior; and 3) for people identified with certain types of depression or increased suicide risk, a systematic multilevel collaborative approach. While for practical reasons the majority of patients with depression will continue to be treated by general or family practitioners, the allergy-treating provider should always consider integrated care for bipolar, psychotic or suicidal depression and incomplete remission, or relapsing and highly recurrent course. While awaiting results of much needed basic and clinical research to guide clinical approach for patients with comorbid allergic rhinitis and depression, the simple steps recommended here are expected to improved clinical outcomes in depression, including, on a large scale, reduced premature deaths by suicide.

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Section: Ar and Depressionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Amritwar

Lowry

Brenner³

et al. 2017

Curr Treat Options Allergy

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“…Furthermore, previous studies have shown the association between asthma and anxiety ( 4 ), depressive, bipolar, and overall mood disorders ( 5 , 6 ), attention-deficit hyperactivity disorder (ADHD) ( 7 , 8 ), schizophrenia ( 9 ), and even dementia ( 10 ). Some studies have also demonstrated the associations between allergic rhinitis and depressive disorder ( 11 , 12 ) or bipolar disorder ( 13 ). The association between atopic dermatitis and depressive and anxiety disorders has also been reported ( 14 ).…”

Section: Introductionmentioning

confidence: 99%

Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study

et al. 2018

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Background/objectiveAllergic diseases, such as bronchial asthma, allergic rhinitis, atopic dermatitis, and psychiatric disorders, are major health issues. There have been reports that allergic diseases were associated with depression or anxiety disorders. This study aimed to investigate the association between these allergic diseases and the risk of developing overall psychiatric disorders in patients from Taiwan.MethodsThis cohort study used the database of the Taiwan National Health Insurance Program. A total of 186,588 enrolled patients, with 46,647 study subjects who had suffered from allergic diseases, and 139,941 controls matched for sex and age, from the Longitudinal Health Insurance Dataset of 2000–2015, were selected from a sub-dataset of the National Health Insurance Research Database. Fine and Gray’s competing risk model analysis was used to explore the hazard ratio (HR), and 95% confidence interval, for the risk of allergic diseases being associated with the risk of developing psychiatric disorders during the 15 years of follow-up.ResultsOf the study subjects, 5,038 (10.8%) developed psychiatric disorders when compared to 9,376 (6.7%) in the control group, with significant difference (p < 0.001). Fine and Gray’s competing risk model analysis revealed that the adjusted HR was 1.659 (95% CI = 1.602–1.717, p < 0.001). In this study, we found that the groups of atopic dermatitis alone and the allergic rhinitis + atopic dermatitis were associated with a lower risk of psychiatric disorders, but all the other four groups, such as bronchial asthma alone, allergic rhinitis alone, bronchial asthma + allergic rhinitis, bronchial asthma + atopic dermatitis, and the combination of all these three allergic diseases, were associated with a higher risk of psychiatric disorders.ConclusionAllergic diseases are therefore associated with a 1.66-fold increased hazard of psychiatric disorders in Taiwan.

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“…Much of the work to date has been cross-sectional, [14][15][16] and relatively few studies have been able to take advantage of longitudinal study designs to examine the association between CPCs and the subsequent risk of MHCs. Available studies have been mostly focused on individual conditions [6][7][8][9][10][11][12][13][17][18][19][20] rather than the general impact of CPCs; global associations illustrate the population level impact of CPCs and may better inform the design of broad-based interventions that adopt population health management strategies. With few exceptions, 8 authors of existing studies have also relied on clinically drawn samples rather than nationally representative samples that may be more generalizable.…”

mentioning

confidence: 99%

Mental Illness Among Youth With Chronic Physical Conditions

2019

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BACKGROUND AND OBJECTIVES: Youth with chronic physical conditions (CPCs) may be at greater risk for developing chronic mental health conditions (MHCs), and limitations in the ability to engage in developmentally appropriate activities may contribute to the risk of MHCs among youth with CPCs. We compared the risk of incident MHCs in youth with and without CPCs and explored whether activity limitations contribute to any such association. METHODS: The 2003–2014 Medical Expenditure Panel Survey provided a nationally representative cohort of 48 572 US youth aged 6 to 25 years. We calculated the 2-year cumulative incidence of MHCs overall and by baseline CPC status. Cox proportional hazard models were used to estimate the association between CPCs and incident MHCs, adjusting for sociodemographic characteristics. Stepwise models and the Sobel test evaluated activity limitations as a mediator of this relationship. RESULTS: The 2-year cumulative incidence of MHCs was 7.8% overall, 11.5% in youth with CPCs (14.7% of sample), and 7.1% in those without. The adjusted risk of incident MHCs was 51% greater (adjusted hazard ratio 1.51; 95% confidence interval 1.30–1.74) in youth with CPCs compared with those without. Activity limitations mediated 13.5% of this relationship (P < .001). CONCLUSIONS: This nationally representative cohort study supports the hypotheses that youth with CPCs have increased risk for MHCs and that activity limitations may play a role in MHC development. Youth with CPCs may benefit from services to bolster their ability to participate in developmentally important activities and to detect and treat new onset MHCs.

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Risk of bipolar disorder among adolescents with allergic rhinitis: A nationwide longitudinal study

Cited by 12 publications

References 28 publications

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior

Increased Risk of Psychiatric Disorders in Allergic Diseases: A Nationwide, Population-Based, Cohort Study

Mental Illness Among Youth With Chronic Physical Conditions

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