Risk of autism spectrum disorder in offspring with parental schizophrenia: a systematic review and meta-analysis

Shayestehfar, Monir; Nakhostin-Ansari, Amin; Memari, Amir Hossein; Asl, Seyed Hossein Hosseini; Faghihi, Faezeh

doi:10.1080/08039488.2022.2070664

Nordic Journal of Psychiatry

2022

DOI: 10.1080/08039488.2022.2070664

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Risk of autism spectrum disorder in offspring with parental schizophrenia: a systematic review and meta-analysis

Monir Shayestehfar

Amin Nakhostin-Ansari

Amir Hossein Memari

et al.

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2024

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Cited by 2 publications

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Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study

Tuan,

Chen,

Chen

et al. 2024

J Autism Dev Disord

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The mean diagnosis age of autism was about 5 years in Taiwan. Whether the delayed diagnosis of autism (≥ 6 years) was associated with parental severe mental disorders remained unknown. The parents of 22,859 autistic individuals and 228,590 age- and sex-matched nonautistic individuals were assessed for the presence of severe mental disorders (schizophrenia, bipolar disorder, major depressive disorder, alcohol use disorder, and substance use disorder). The timing of autism diagnosis was classified into three age categories: < 6 years, 6–11 years, and ≥ 12 years. Logistic regression models were used to examine associations between parental severe mental disorders and these age categories of autism diagnosis. Parental schizophrenia and substance use disorders were associated with the delayed diagnosis of autism, both diagnosis at ≥ 12 years (odds ratio [OR]: 2.14; 1.57) and at 6–11 years (1.87; 1.38). Parental bipolar disorder and major depressive disorder were also associated with the delayed diagnosis of autism, especially diagnosis at 6–11 years (OR 1.98; 1.86). Our findings underscore the need for clinicians to monitor the neurodevelopmental conditions of offspring born to parents with severe mental disorders during the early stages of their life.

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Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study

Tuan,

Chen,

Chen

et al. 2024

J Autism Dev Disord

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Integrating parental psychopathologies in autism spectrum disorder care: Toward a holistic family-centric approach

Dubey,

Ghosh,

Dubey

et al. 2024

Indian Journal of Psychiatry

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Risk of autism spectrum disorder in offspring with parental schizophrenia: a systematic review and meta-analysis

Cited by 2 publications

References 47 publications

Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study

Effect of Parental Severe Mental Disorders on the Timing of Autism Diagnosis: A Family Linkage Study

Integrating parental psychopathologies in autism spectrum disorder care: Toward a holistic family-centric approach

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