Risk of anxiety and depression in patients with lichen planus: A nationwide population-based study

Hsu, Dun-Yu; Chien, Wu-Chien; Chung, Chi‐Hsiang; Chiu, Kuo-Chou; Li, Tsung-I; Kung, Ling-Yu; Tzeng, Nian‐Sheng

doi:10.1016/j.jad.2021.12.127

Cited by 12 publications

(10 citation statements)

References 40 publications

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“…Indeed, no A was reported in 47.3% (142) of the K-OLP patients compared to 62% (186) of the HC. A was found in 52.7% (158) of the K-OLP group; 40.7% (122) presented mild A, 7.7% (23) moderate A, and 4.3% (13) severe A in comparison with 32% (96), 5% (15) and 1% (3) of the HC, respectively. With regard to the HAM-D score categories, instead, 50.7% (152) of the K-OLP patients reported no D compared with 64% (192) of the HC.…”

Section: Resultsmentioning

confidence: 93%

“…The synergic association between OLP, A, and D may further contribute to a poor quality of life and an increased level of stress among such subjects. [14] Despite recent studies have suggested a strong association between OLP and mood disorders [7,15,16], with an overall estimated prevalence of 54.76% and 31.19% of OLP patients suffering from A and D [1], few studies have analyzed the prevalence of A and D in a subset of patients with K-OLP. Therefore, we decided to perform a multicentric study in our country in a large cohort of patients with K-OLP to confirm this association and to better understand the role of the sociodemographic profile, risk factors, and oral symptoms in the development of A and D in this subgroup of OLP patients.…”

Section: Introductionmentioning

confidence: 99%

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Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

et al. 2023

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Objectives Oral lichen planus with exclusive keratotic reticular, papular, and/or plaque-like lesions (K-OLP) is a clinical pattern of OLP that may be associated with a complex symptomatology and psychological alteration. The aim of the study was to evaluate the prevalence of anxiety (A) and depression (D) in patients with K-OLP, analyzing the potential predictors which can affect mental health status. Methods Three hundred K-OLP patients versus 300 healthy controls (HC) were recruited in 15 Italian universities. The Numeric Rating Scale (NRS), Total Pain Rating Index (T-PRI), and Hamilton Rating Scales for Depression and for Anxiety (HAM-D and HAM-A) were administered. Results The K-OLP patients showed statistically higher scores in the NRS, T-PRI, HAM-D, and HAM-A compared with the HC (p-value < 0.001**). A and D were found in 158 (52.7%) and 148 (49.3%) K-OLP patients. Strong linear correlations were identified between HAM-A, HAM-D, NRS, T-PRI, and employment status and between HAM-D, HAM-A, NRS, T-PRI, employment status, and female gender. Multivariate logistic regression revealed that HAM-D and HAM-A showed the greatest increase in the R2 value for A and D in the K-OLP patients, respectively (DR2 = 55.5% p-value < 0.001**; DR2 = 56.5% p-value < 0.001**). Conclusions The prevalence of A and D is higher in the K-OLP patients compared with the HC, also found in K-OLP subjects without pain, suggesting that the processing of pain may be in a certain way independent of the processing of mood. Clinical relevance Mood disorders and pain assessment should be carefully performed in relation to K-OLP to obtain a complete analysis of the patients.

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Section: Resultsmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

et al. 2023

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“…In this study, we used data from the NHIRD to investigate the association between patients with hirsutism (ICD-9-CM: 704.1), PCOS (ICD-9-CM:256.4 and 628.0), acne (ICD-CM:706.1), and psychiatric disorders (ICD-9-CM:290–319) over a 16-year period, from the total hospitalization Longitudinal Health Insurance Database in Taiwan (2000–2015). 16 …”

Section: Methodsmentioning

confidence: 99%

“…12 In this study, we used data from the NHIRD to investigate the association between patients with hirsutism (ICD-9-CM: 704.1), PCOS (ICD-9-CM:256.4 and 628.0), acne (ICD-CM:706.1), and psychiatric disorders (ICD-9-CM:290-319) over a 16-year period, from the total hospitalization Longitudinal Health Insurance Database in Taiwan (2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)(2013)(2014)(2015). 16 clinical manifestation criteria were referred to the study group; participants without clinical features were referred to the control group (Figure 1).…”

Section: Data Sourcementioning

confidence: 99%

Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan

Wang¹,

Chou²,

Lee³

et al. 2022

IJWH

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Objective Previous studies have shown an increased in psychiatric disorders in women with disorders associated with hyperandrogenism, but few nationwide cohorts have studied this phenomenon. Therefore, this study is aimed to examine the association between the clinical manifestations of hyperandrogenism and subsequent psychiatric disorders. Methods Based on the National Health Insurance Research Database, 49,770 enrolled participants were matched for age and index date between January 1, 2000, and December 31, 2015. Hirsutism, polycystic ovary syndrome, and acne are characterized by hyperandrogenism. After adjusting for confounding factors, we used Cox proportional analysis to compare the risk of psychiatric disorders during the 16 years of follow-up. Results Of all the participants, 1319 (13.25%) had psychiatric disorders in the study group, whereas only 3900(9.80%) had psychiatric disorders in the control group. After adjusting for age, and monthly income, the Cox regression analysis showed that the study patients were more likely to develop psychiatric disorders (hazard ratio [HR]: 2.004, 95% confidence interval [CI] = 1.327–2.724, P < 0.001). The results demonstrated that women aged 20–29 years had a more significant risk. Conclusion Women with clinical characteristics of hyperandrogenism have a higher risk of developing psychiatric disorders, especially those aged 20–29 years.

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“…In line with the biopsychosocial model, a growing body of evidence is increasingly implicating psychosocial factors in the development of changes in lichen planus, burning mouth syndrome, and chronic recurrent aphthous stomatitis; however, there is still little known about the specific psychological functioning of patients diagnosed with these diseases [ 19 , 21 , 33 , 34 , 35 , 36 ]. Studies indicate that patients with LP show increased levels of psychosocial stress [ 36 ] and suffer more often from anxiety and depression, which are the most common causes of change in oral tissues [ 34 , 37 ]. It is also observed that patients with diseases of the oral cavity report subjective increases of symptoms during times of higher life stressors [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

Psychological Functioning of Women Diagnosed with Lichen Planus and Other Diseases of the Oral Cavity—Explorative Study

Sajewicz-Radtke¹,

Radtke²,

Jurek

et al. 2023

Healthcare

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The role of psychosocial factors in the development of changes in lichen planus and other diseases of the oral cavity has been implicated, but is still understudied. Therefore, the aim of our study was to describe the specific profile of psychological functioning of patients with these diseases, including the role of temperamental traits, action-oriented personality components, and self-esteem. In total, 94 adult women participated in the study: (1) with lichen planus (LP; n = 46; Mage = 54.80, SD = 12.53), (2) with other oral conditions (n = 25; Mage = 34.76, SD = 16.03), (3) without chronic disease (n = 24; Mage = 40.96, SD = 13.33). The following questionnaires were used: ZKA-PQ/SF, Polish Adaptive and Maladaptive Perfectionism Questionnaire, ACS-90, PROCOS, and MSEI. Results indicated no significant differences in temperament dimensions between studied groups. However, women diagnosed with LP presented lower levels of maladaptive perfectionism and social support than healthy women. Furthermore, women with LP also obtained lower scores for social resourcefulness and higher scores for moral self-approval than healthy women. Summarizing, patients with LP often use compensatory mechanisms that negatively affect their social functioning; thus diagnostic/therapeutic programs directed towards those group should be holistic, including psychologists and psychiatrists who support patients’ psychological well-being.

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Risk of anxiety and depression in patients with lichen planus: A nationwide population-based study

Cited by 12 publications

References 40 publications

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Anxiety and depression in keratotic oral lichen planus: a multicentric study from the SIPMO

Clinical Characteristics of Hyperandrogenism Include Hirsutism, Polycystic Ovary Syndrome, and Acne: Association with Psychiatric Disease in Women -A Nationwide Population-Based Cohort Study in Taiwan

Psychological Functioning of Women Diagnosed with Lichen Planus and Other Diseases of the Oral Cavity—Explorative Study

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