Risk of Alzheimer’s Disease in Cancer Patients: Analysis of Mortality Data from the US SEER Population-Based Registries

Mezencev, Roman; Chernoff, Yury O.

doi:10.3390/cancers12040796

Cited by 18 publications

(14 citation statements)

References 104 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been found that compared to people without Alzheimer's dementia the risk of developing cancer is lower among patients with AD while the risk of developing AD is lower in patients with a history of cancer [8][9][10]. The results of the current research indicate the link between the molecular mechanisms involved in various types of cancers and AD, and encourage the use of some anticancer agents in the treatment of AD [11][12][13][14]. The knowledge and understanding gained from these studies can be applied for developing new therapies and designing new effective drugs for the treatment of both diseases.…”

Section: Introductionmentioning

confidence: 56%

“…Molecules 2020, 25, 2604 2 of 13 between the molecular mechanisms involved in various types of cancers and AD, and encourage the use of some anticancer agents in the treatment of AD [11][12][13][14]. The knowledge and understanding gained from these studies can be applied for developing new therapies and designing new effective drugs for the treatment of both diseases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity

et al. 2020

View full text Add to dashboard Cite

The inverse correlation observed between Alzheimer’s disease (AD) and cancer has prompted us to look for cholinesterase-inhibiting activity in phenothiazine derivatives that possess anticancer properties. With the use of in silico and in vitro screening methods, our study found a new biological activity in anticancer polycyclic, tricyclic, and tetracyclic compounds. The virtual screening of a library of 120 ligands, which are the derivatives of azaphenothiazine, led to the identification of 25 compounds that can act as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). Biological assays revealed the presence of selective inhibitors of eeAChE (electric eel AChE) or eqBuChE (equine serum BuChE) and nonselective inhibitors of both enzymes among the tested compounds. Their potencies against eeAChE were in a submicromolar-to-micromolar range with IC50 values from 0.78 to 19.32 μM, while their IC50 values against eqBuChE ranged from 0.46 to 10.38 μM. The most potent among the compounds tested was the tetracyclic derivative, 6-(4-diethylaminobut-2-ynyl)-9-methylthioquinobenzothiazine 24, which was capable of inhibiting both enzymes. 9-Fluoro-6-(1-piperidylethyl)quinobenzothiazine 23 was found to act as a selective inhibitor of eqBuChE with an IC50 value of 0.46 μM. Compounds with such a dual antitumor and cholinesterase-inhibitory activity can be considered as a valuable combination for the treatment of both cancer and AD prevention. The results presented in this study might open new directions of research on the group of tricyclic phenothiazine derivatives.

show abstract

Section: Introductionmentioning

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…The most important amyloid-associated diseases include Alzheimer’s and Parkinson’s diseases, type 2 diabetes, and transmissible spongiform encephalopathies (TSEs), or prion diseases, such as Creutzfeldt-Jakob disease [ 6 ]. Recent data indicate that amyloids are also associated with preeclampsia and some forms of cancer, although this is unclear whether amyloids cause these diseases or arise as a consequence of the disease and serve as biomarkers [ 7 , 8 , 9 , 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Functional Mammalian Amyloids and Amyloid-Like Proteins

Rubel

Fedotov

Grizel

et al. 2020

Life

Self Cite

View full text Add to dashboard Cite

Amyloids are highly ordered fibrous cross-β protein aggregates that are notorious primarily because of association with a variety of incurable human and animal diseases (termed amyloidoses), including Alzheimer’s disease (AD), Parkinson’s disease (PD), type 2 diabetes (T2D), and prion diseases. Some amyloid-associated diseases, in particular T2D and AD, are widespread and affect hundreds of millions of people all over the world. However, recently it has become evident that many amyloids, termed “functional amyloids,” are involved in various activities that are beneficial to organisms. Functional amyloids were discovered in diverse taxa, ranging from bacteria to mammals. These amyloids are involved in vital biological functions such as long-term memory, storage of peptide hormones and scaffolding melanin polymerization in animals, substrate attachment, and biofilm formation in bacteria and fungi, etc. Thus, amyloids undoubtedly are playing important roles in biological and pathological processes. This review is focused on functional amyloids in mammals and summarizes approaches used for identifying new potentially amyloidogenic proteins and domains.

show abstract

“…Not only shared genetic and environmental risk factors but the role of a third disease that influences the occurrence of both AD and cancer, effects of treatment, phenotypic causality, in which one disease is a direct cause of the other disease (directional causation), or both disorders may cause one another (reciprocal causation) should be taken into consideration. Recent study on associations between cancer occurrence and AD mortality using data from populationbased cancer registries from the Surveillance, Epidemiology and End Results (SEER) program has estimated the risk of AD death in cancer patients relative to reference populations stratified on demographic and clinical variables [26]. They have showed that the risk of AD death was reduced in white patients diagnosed with various cancers at 45 or more years of age, but it was increased in black patients diagnosed with cancers before 45 years of age (likely due to early onset AD).…”

Section: Association Between Cancer and Alzheimer's Diseasementioning

confidence: 99%

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

et al. 2021

View full text Add to dashboard Cite

The negative association between Alzheimer’s disease (AD) and cancer suggests that susceptibility to one disease may protect against the other. When biological mechanisms of AD and cancer and relationship between them are understood, the unsolved problem of both diseases which still touches the growing human population could be overcome. Actual information about biological mechanisms and common risk factors such as chronic inflammation, age-related metabolic deregulation, and family history is presented here. Common signaling pathways, e.g., p53, Wnt, role of Pin1, and microRNA, are discussed as well. Much attention is also paid to the potential impact of chronic viral, bacterial, and fungal infections that are responsible for the inflammatory pathway in AD and also play a key role to cancer development. New data about common mechanisms in etiopathology of cancer and neurological diseases suggests new therapeutic strategies. Among them, the use of nilotinib, tyrosine kinase inhibitor, protein kinase C, and bexarotene is the most promising.

show abstract

Risk of Alzheimer’s Disease in Cancer Patients: Analysis of Mortality Data from the US SEER Population-Based Registries

Cited by 18 publications

References 104 publications

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity

Dual Action of Dipyridothiazine and Quinobenzothiazine Derivatives—Anticancer and Cholinesterase-Inhibiting Activity

Functional Mammalian Amyloids and Amyloid-Like Proteins

Inverse Correlation Between Alzheimer’s Disease and Cancer: Short Overview

Contact Info

Product

Resources

About