Risk of adult‐onset asthma increases with the number of allergic multimorbidities and decreases with age

Abstract

Background:The aim was to study the association between allergic multimorbidity and adult-onset asthma considering the number of allergic diseases and the age effect. Methods:We used population-based data from Finnish national registers including 1205 adults over 30 years of age with recently diagnosed asthma (age range: 30-93), matched for gender, age, and living region with one or two controls (n = 2050).Allergic rhinitis (AR), allergic conjunctivitis (AC), and allergic dermatitis (AD) were defined from self-completed questionnaire. Conditional logistic regression adjusted on potential confounders (smoking, growing in countryside, childhood hospitalized infection/pneumonia, parental asthma/allergy, parental smoking, education level, professional training, number of siblings, and birth order) was applied to estimate the asthma risk associated with allergic multimorbidity.Results: A total of 1118 cases with asthma and 1772 matched controls were included [mean (SD, min-max) 53 (11, 31-71) years, 37% men)]. AR, AC, and AD were reported by 50.2%, 39.6%, and 33.8%, respectively, among subjects with asthma and 26.1%, 20.0%, and 23.5%, respectively, among controls. Compared to nonatopics, adult-onset asthma increased with the number of allergic diseases; adjusted OR for | 2407 TOPPILA-SALMI eT AL

Aligning the Good Practice MASK With the Objectives of the European Innovation Partnership on Active and Healthy Ageing

“…24 These results obtained using a big data approach in days were confirmed in canonical epidemiologic studies in patients. [38][39][40][41] Pro-active prevention through empowerment, self-management, monitoring and coaching…”

“…MASK STUDY GROUP: J Bousquet, 1,2,3,4,5,6,7* J Farrell, 8 GL Onorato, 2 A Bedbrook, 2 W Czarlewski, 9 Y Micheli, 10 S Arnavielhe, 10 M Illario, 11 IJ Ansotegui, 12 JM Anto, 13,14,15,16 C Bachert, 17 X Basagaña, 13 A Bédard, 13 S Benveniste, 18,19 KC Bergmann, 6,7 M Bewick, 20 C Bindslev-Jensen, 21 L Bjermer, 22 H Blain, 23,24 S Bosnic-Anticevich, 25 I Bosse, 26 F Braido, 27 L Brussino, 28 T Camuzat, 29 GW Canonica, 30 V Cardona, 31 P Carreiro Martins, 32,33 L Cecchi, 34 NH Chavannes, 35 DK Chu, 36,37 J Correia da Sousa, 38,39 DJ Costa, 40 E Costa, 41 AA Cruz, 42,43 J da Silva, 44 P Devillier, 45 G De Feo, 46 G De Vries, 47 G Dray, 48 M Ebisawa, 49 M Erhola, 50 JL Fauquert, 51 WJ Fokkens, 5,52 J Fonseca, 53,54 JM Fontaine, 55 B Gemicioğlu, 56 T Haahtela, 57 E Heffler, 30 PW Hellings, 5,58,59 JC Ivancevich, 60 E Jassem, 61 M Jutel, 62…”

Airway Epithelial Dynamics in Allergy and Related Chronic Inflammatory Airway Diseases

“…The risk factors for asthma include AR and allergic conjunctivitis, atopic dermatitis, exposure to air pollution, cigarette smoke, occupational risk factors, obesity, and genetic factors (Polosa and Thomson, 2013;Ilmarinen et al, 2015;Toskala and Kennedy, 2015;Willis-Owen et al, 2018;Toppila-Salmi et al, 2019). Childhood-onset asthma has a stronger genetic component than adult asthma and is triggered due to dysregulated allergy and epithelial barrier function (Pividori et al, 2019;Schoettler et al, 2019).…”

“…Childhood-onset asthma has a stronger genetic component than adult asthma and is triggered due to dysregulated allergy and epithelial barrier function (Pividori et al, 2019;Schoettler et al, 2019). The development of adult asthma is more likely in patients with an accumulation of several risk factors and with allergic multimorbidities (Hallit et al, 2019;Pividori et al, 2019;Toppila-Salmi et al, 2019). Asthma, rhinitis, and chronic rhinosinusitis often co-exist (Jarvis et al, 2012).…”

Risk factors of severe adult-onset asthma: a multi-factor approach

“…The Adult Asthma in Finland is a population-based matched case-control study conducted in 1997 ( Figure 1) as previously described (24). This study collected information from 1350 asthma patients older than 30 years of age with an asthma diagnosis.…”