Risk of acute pulmonary embolism in COVID-19 pneumonia compared to community-acquired pneumonia: a retrospective case–control study

Elsayed, Manal; Jones, Tracey

doi:10.1016/j.crad.2021.03.014

Cited by 4 publications

(2 citation statements)

References 29 publications

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“…This is in line with previous comparisons between patients with COVID-19 and sepsis, 32 , 33 although other studies reported increased D-dimer in COVID-19 when compared with other CAPs. 34 , 35 Together, our data may indicate that high PAI-1 levels could limit fibrin degradation and subsequent D-dimer release, resulting in relatively low D-dimer levels in COVID-19.…”

Section: Discussionmentioning

confidence: 70%

The host response in different aetiologies of community-acquired pneumonia

et al. 2022

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Section: Discussionmentioning

confidence: 70%

The host response in different aetiologies of community-acquired pneumonia

et al. 2022

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“…The study period in this cohort may have been the factor leading to this finding. The study is conducted at a time when several COVID-19-related studies are published, demonstrating that patients with COVID-19 infections are at increased risk of developing thrombosis [27][28][29]. We postulate that these studies may have influenced treating physicians to proceed with CTPA even though there is a lack of clinical evidence suggesting PE, lowering the odds of positive results in these CTPAs.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Yield of CT Pulmonary Angiogram in the Diagnosis of Pulmonary Embolism and Its Predictive Factors

Low,

Kow,

Abd Aziz

et al. 2023

Cureus

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Introduction Computed tomography pulmonary angiography (CTPA) is the reference investigation of choice to diagnose pulmonary embolism (PE). Nevertheless, the use of CTPA should be weighed against its risks, such as radiation and contrast-induced nephropathy. We aim to assess the yield of CTPA in diagnosing PE at a tertiary centre in Malaysia. We also identify predictive factors associated with the yield of CTPA in this cohort. Methods This was a cross-sectional study involving all patients who had had CTPA done at Hospital Tengku Ampuan Afzan, Kuantan, Malaysia, from January 1, 2021, to November 30, 2021. All patients’ records were retrieved and reviewed. CTPA images were retrieved from the Radiology Information System (RIS) and Picture Archiving and Communication System (PACS). They were double-reviewed by the authors, with the initial reports redacted from reporting radiologists to prevent reporting bias. The predictive factors were determined using simple logistic regression and multiple logistic regression. Results A total of 351 CTPAs were reviewed, of which 93 were found to be positive for PE, giving rise to an overall CTPA yield of 26.5%. Upon simple logistic regression, factors such as gender, discipline, history of trauma, presence of COVID-19 infection, and pneumonia were found to be associated with positive CTPA. Upon multiple logistic regression, male patients were found to have a higher chance of positive CTPA results. On the other hand, patients with COVID-19 infection and pneumonia have a lower chance of positive results in CTPA. Conclusion The yield of CTPA in diagnosing PE at our institution was acceptable at 26.5%. Upon multiple logistic regression, patients with COVID-19 infection and pneumonia were more likely to have a negative CTPA result, highlighting the need for clinicians to be more prudent in requesting CTPAs in these patients.

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