Risk of Acute Kidney Injury From Oral Acyclovir: A Population-Based Study

Lam, Ngan N.; Weir, Matthew A.; Yao, Zhan; Blake, Peter G.; Beyea, Michael M.; Gomes, Tara; Gandhi, Sumeet; Mamdani, Muhammad; Wald, Ron; Parikh, Chirag R.; Hackam, Daniel G.; Garg, Amit X.

doi:10.1053/j.ajkd.2012.12.008

Cited by 46 publications

(40 citation statements)

References 31 publications

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“…Acyclovir, which is relatively insoluble in urine, is rapidly filtered by the glomeri and secreted by the renal tubules, which can produce high urine concentrations, particularly in patients with decreased urine flow rates (16)(17)(18)(19). Renal excretion accounts for 60-90% of acyclovir elimination (20).…”

Section: Discussionmentioning

confidence: 99%

Acute renal injury induced by valacyclovir hydrochloride: A case report

Zhang

Cong

Teng

2016

Experimental and Therapeutic Medicine

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Abstract. Acyclovir has been a frequently used antiviral agent in the clinical treatment of leukemia, acute encephalitis, malignant tumor and herpes simplex. The adverse effects of this drug have been widely described in clinical practice. In the present study, a case of a 35-year-old female patient diagnosed with herpes simplex, who developed acute renal injury following treatment with valacyclovir hydrochloride, is described. Kidney biopsy, light microscopy and laboratory examination were performed, and all findings revealed the signs of evident vacuolar degeneration of capillary endothelial and renal tubular epithelial cells, erythrocyte aggregation in partial renal tubule and microvilli exfoliation from epithelial cells. Renal interstitial edema was clearly identified. The clinical evidence observed from this female patient indicated that renal functions should be closely monitored during valacyclovir hydrochloride administration. A variety of effective measures, such as hydration, alkalizing urine, promoting the discharge of medication and the use of antagonists are recommended following the administration of antiviral agents.

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Section: Discussionmentioning

confidence: 99%

Acute renal injury induced by valacyclovir hydrochloride: A case report

Zhang

Cong

Teng

2016

Experimental and Therapeutic Medicine

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“…These databases have been used extensively for research on health outcomes and services including studies on cardiovascular disease. [11][12][13][14][15][16][17][18][19] The majority of the data were complete with the exception of income (0.3% missing), donor status (1% missing), primary cause of end-stage renal disease (ESRD) (8% missing), and race (10% missing).…”

Section: Data Sourcesmentioning

confidence: 99%

The Risk of Cardiovascular Disease Is Not Increasing Over Time Despite Aging and Higher Comorbidity Burden of Kidney Transplant Recipients

et al. 2017

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“…However, it may also be associated with oral administration [9]. It is more common in immunosuppressed patients, probably due to the fact that acyclovir is more widely indicated in this patient group [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Acyclovir Crystalluria: A Rare Secondary Effect of a Common Drug

Lorenzo¹

2016

Pediat Therapeut

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Acyclovir is a highly active antiviral drug that acts against the herpes simplex virus (HSV). Among its secondary effects, we can observe rare cases of crystalluria, which can be associated or not associated to renal failure. We present the case of a healthy lactating 13-month-old baby girl with gingivostomatitis, who 48 hours after the start of treatment with this drug showed a change in the color of her urine, which was associated with the appearance of crystals in the sediment. This finding was associated with the prescription of Acyclovir, because it has been described in the literature, and no other ascribable causes could be found. Crystalluria is a rare adverse effect that has been reported generally in adult immunosuppressed patients. We have only been able to find one case that could be compared to ours, in an immunocompetent pediatric patient in which a momentary treatment was implemented to treat a herpetic infection.

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Risk of Acute Kidney Injury From Oral Acyclovir: A Population-Based Study

Cited by 46 publications

References 31 publications

Acute renal injury induced by valacyclovir hydrochloride: A case report

Acute renal injury induced by valacyclovir hydrochloride: A case report

The Risk of Cardiovascular Disease Is Not Increasing Over Time Despite Aging and Higher Comorbidity Burden of Kidney Transplant Recipients

Acyclovir Crystalluria: A Rare Secondary Effect of a Common Drug

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