Risk of active tuberculosis among people with diabetes mellitus: systematic review and meta‐analysis

Hayashi, Shigenari; Chandramohan, Daniel

doi:10.1111/tmi.13133

Cited by 67 publications

(55 citation statements)

References 37 publications

(70 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This study demonstrated that most TB patients had already suffered from diabetes. This discovery is according to a research by Hayashi and Chandramohan who conducted a meta-analysis of 14 studies [11]. Most respondents had a period of 0-5 years from being diagnosed with DM to being diagnosed with TB and are new TB patients.…”

Section: Discussionmentioning

confidence: 98%

Reduction of Tumor Necrosis Factor-Alpha and Interferon-Gamma Concentration on Tuberculosis With Diabetes Mellitus as a Marker in Decrease Immune System

Marissa

Ramadhan

Hanum

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: This study aimed to determine the decreased immune response of tuberculosis (TB) with diabetes mellitus (DM) patients. Methods: A total of 105 TB patients who were undergoing treatment at health centers and hospitals in Banda Aceh and Aceh Besar were included in this study. Data collection was carried out by interviewed to obtained demographic and respondent categories based on the diagnosis. Measurements of height and weight were also conducted to obtain body mass index data. 5 mL peripheral blood was taken from each respondent group into a TB with DM (TB+DM) and TB without DM (TB-DM). The blood tested usage tumor necrosis factor-alpha (TNF-α) level using enzyme-linked immunosorbent assay and interferon-gamma (IFN-γ) using IFN-γ release assay. Results: The average concentration of both TNF-α and IFN-γ was higher in TB-DM group (TNF-a 5.2 pg/mL; IFN-g 1.5 IU/mL) than in TB+DM group (TNF-a 2.06 pg/mL; IFN-g 2.86 IU/mL). There were significant differences in TNF-α between the two groups but no significant differences in IFN-γ protein concentration. Conclusion: The immune response of TB patients with DM symptoms was markedly reduced by the decreased expression of TNF-α and IFN-γ.

show abstract

Section: Discussionmentioning

confidence: 98%

Reduction of Tumor Necrosis Factor-Alpha and Interferon-Gamma Concentration on Tuberculosis With Diabetes Mellitus as a Marker in Decrease Immune System

Marissa

Ramadhan

Hanum

et al. 2019

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

“…In acutely unwell patients, under-nutrition may also increase the risk of inpatient death due to increased risk of severe metabolic and electrolyte disturbances [16–18]. Type 2 Diabetes Mellitus (T2DM) is another known risk factor for active TB [19]. T2DM, especially when poorly controlled, may increase the risk of death and relapse during TB disease [20] whilst TB may also negatively affect glycaemic control [21].…”

Section: Introductionmentioning

confidence: 99%

Mid-upper arm circumference predicts death in adult patients admitted to a TB ward in the Philippines: A prospective cohort study

et al. 2019

View full text Add to dashboard Cite

Background The Philippines is ranked 3 rd globally for tuberculosis incidence (554/100,000 population). The tuberculosis ward at San Lazaro Hospital, Manila receives 1,800–2,000 admissions of acutely unwell patients per year with high mortality. Objectives of this prospective cohort study were to quantify the association of under-nutrition (primary) and diabetes (secondary) with inpatient mortality occurring between 3–28 days of hospital admission in patients with suspected or previously diagnosed TB. Methods and results We enrolled 360 adults (≥18 years); 348 were eligible for the primary analysis (alive on day 3). Clinical, laboratory, anthropometric and enhanced tuberculosis diagnostic data were collected at admission with telephone tracing for mortality up to 6 months post-discharge. In the primary analysis population (mean age 45 years, SD = 15.0 years, 70% male), 58 (16.7%) deaths occurred between day 3–28 of admission; 70 (20.1%) between day 3 and discharge and documented total post-day 3 mortality including follow-up was 96 (27.6%). In those in whom it could be assessed, body mass index (BMI) ranged from 11.2–30.6 kg/m 2 and 141/303 (46.5%) had moderate/severe undernutrition (BMI<17 kg/m 2 ). A sex-specific cut-off for mid-upper arm circumference predictive of BMI<17 kg/m 2 was associated with inpatient Day 3–28 mortality in males (AOR = 5.04, 95% CI: 1.50–16.86; p = 0.009; p = 0.032 for interaction by sex). The inability to stand for weight/height for BMI assessment was also associated with mortality (AOR = 5.59; 95% CI 2.25–13.89; p<0.001) as was severe compared to normal/mild anaemia (AOR = 9.67; 95% CI 2.48–37.76; p<0.001). No TB specific variables were associated with Day 3–28 mortality, nor was diabetes (HbA1c ≥6.5% or diabetes treatment). Similar effects were observed when the same multivariable model was applied to confirmed TB patients only and to the outcome of all post-day 3 in-patient mortality. Conclusion This research supports the use of mid-upper arm circumference for triaging acutely unwell patients and the design and testing of nutrition-based interventions to improve patient outcomes.

show abstract

“…The complexity of the disease is due to many factors including the ability of Mycobacterium tuberculosis (Mtb), the causative agent of TB, to enter slow/non-replicating states, to remodel metabolic and respiratory systems, to cause latent infection, together with the increasing emergence of drug-resistant Mtb (Ayabina et al, 2016;Dheda et al, 2017;Bekele et al, 2018;Gordon and Parish, 2018;Singh et al, 2019). The impact of TB is also worsened by the high rate of Mtb infections among patients with chronic diseases like diabetes mellitus and HIV infection (Hayashi and Chandramohan, 2018;Fernandez et al, 2020). Among people living with HIV, the progression from TB infection to disease occurs at a high rate, positioning TB as the leading cause of mortality in this population (Peters et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Characterization of the Mycobacterial MSMEG-3762/63 Efflux Pump in Mycobacterium smegmatis Drug Efflux

et al. 2020

View full text Add to dashboard Cite

Multi-drug resistant tuberculosis (MDR-TB) represents a major health problem worldwide. Drug efflux and the activity of efflux transporters likely play important roles in the development of drug-tolerant and drug-resistant mycobacterial phenotypes. This study is focused on the action of a mycobacterial efflux pump as a mechanism of drug resistance. Previous studies demonstrated up-regulation of the TetR-like transcriptional regulator MSMEG_3765 in Mycobacterium smegmatis and its ortholog Rv1685c in Mycobacterium tuberculosis (Mtb) in acid-nitrosative stress conditions. MSMEG-3765 regulates the expression of the MSMEG_3762/63/65 operon, and of the orthologous region in Mtb (Rv1687c/86c/85c). MSMEG-3762 and Rv1687c are annotated as ATP-binding proteins, while MSMEG-3763 and Rv1686c are annotated as trans-membrane polypeptides, defining an ABC efflux pump in both M. smegmatis and Mtb. The two putative efflux systems share a high percentage of identity. To examine the role of the putative efflux system MSMEG-3762/63, we constructed and characterized a MSMEG-3763 deletion mutant in M. smegmatis (∆MSMEG_3763). By comparative analysis of wild type, knockout, and complemented strains, together with structural modeling and molecular docking bioinformatics analyses of the MSMEG-3763 trans-membrane protein, we define the protein complex MSMEG-3762/63 as an efflux pump. Moreover, we demonstrate involvement of this pump in biofilm development and in the extrusion of rifampicin and ciprofloxacin (CIP), antimicrobial drugs used in first- and second-line anti-TB therapies.

show abstract

Risk of active tuberculosis among people with diabetes mellitus: systematic review and meta‐analysis

Abstract: There is evidence suggesting an increased risk of developing TB among people with DM, and that improving glycaemic control in DM patients would reduce the risk of developing TB. An integrated approach is needed to control the dual burden of DM and TB.

Cited by 67 publications

References 37 publications

Reduction of Tumor Necrosis Factor-Alpha and Interferon-Gamma Concentration on Tuberculosis With Diabetes Mellitus as a Marker in Decrease Immune System

Reduction of Tumor Necrosis Factor-Alpha and Interferon-Gamma Concentration on Tuberculosis With Diabetes Mellitus as a Marker in Decrease Immune System

Mid-upper arm circumference predicts death in adult patients admitted to a TB ward in the Philippines: A prospective cohort study

Characterization of the Mycobacterial MSMEG-3762/63 Efflux Pump in Mycobacterium smegmatis Drug Efflux

Contact Info

Product

Resources

About