Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study

Song, Fengju; Qureshi, Abrar A.; Giovannucci, Edward; Fuchs, Charles S.; Chen, Wendy Yvonne; Stampfer, Meir J.; Han, Jiali

doi:10.1371/journal.pmed.1001433

Cited by 61 publications

(75 citation statements)

References 47 publications

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“…In the present study, we were able to investigate the association among both women and men with a larger sample size and further differentiate between BCC and SCC based on detailed cohort follow-up information. We found that participants with a history of both BCC and SCC had a more apparently increased risk of melanoma when compared with participants with a history of BCC or SCC alone, thus adding further evidence to our previous report on the association between KC history and melanoma in the NHS and HPFS (18). However, the statistical test for the heterogeneity between history of BCC or SCC alone and history of both BCC and SCC did not reach statistical significance, and further studies are needed to confirm our findings.…”

Section: Articlesupporting

confidence: 83%

“…Our previous study has reported an increased risk of cancer including melanoma in association with history of KC in the Nurses' Health Study (NHS;1984-2008 and Health Professionals Follow-up Study (HPFS;1986-2008 (18). However, this previous report did not examine the detailed subgroups of KC in association with the risk of developing melanoma and melanoma subtypes, did not investigate the impact of multiple KCs on melanoma risk, and did not investigate the potential modification of the KC-melanoma association by other melanoma risk factors.…”

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confidence: 99%

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History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Cho

et al. 2017

JNCI: Journal of the National Cancer Institute

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Background: The association between history of keratinocyte carcinoma (KC, also known as nonmelanoma skin cancer) and risk of developing invasive melanoma has not been assessed comprehensively using prospective data. Methods: We followed 91 846 women in the Nurses' Health Study (NHS; 1984-2010, 114 918 women in the NHSII , and 48 946 men in the Health Professionals Follow-up Study (1986-2010 for diagnoses of KC and melanoma biennially. Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) of melanoma associated with history of KC, basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). All statistical tests were two-sided. Results: We documented 1949 melanomas, 38 842 BCCs, and 7462 SCCs over 6.4 million person-years of follow-up. After adjustment for other risk factors, a personal history of KC was associated with an increased risk of melanoma (meta-analysis HR ¼ 2.22, 95% CI ¼ 1.73 to 2.85). The association was more apparent among participants with a history of both BCC and SCC (HR ¼ 3.40, 95% CI ¼ 1.60 to 7.19) than among participants with a history of BCC only (HR ¼ 2.20, 95% CI ¼ 1.80 to 2.70) or SCC only (HR ¼ 1.56, 95% CI ¼ 0.98 to 2.46), and there was a strong risk-increasing trend associated with a higher number of reported KCs removed by surgery (P trend < .001). In women, KC history was more strongly associated with head/neck melanomas (HR ¼ 4.17, 95% CI ¼ 2.77 to 6.27) than with trunk or limb melanomas (both HRs < 2.50, P heterogeneity ¼ .04). Conclusions: Our results provide novel insights for the relationship between KC history and risk of developing melanoma, which may be important for melanoma prevention.

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Section: Articlesupporting

confidence: 83%

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confidence: 99%

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Cho

et al. 2017

JNCI: Journal of the National Cancer Institute

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“…Song et al found a relative risk for development of MM after diagnosis of a NMSC of 1.99 for men and 2.58 for women. 118 These data were based on 2 large prospective cohort studies with 46,237 men and 107,339 women under study. A smaller study including 3548 people found the relative risk for MM to be 3.28 after diagnosis of BCC.…”

Section: Follow-up and Reducing Risk For Future Skin Cancersmentioning

confidence: 99%

“…[116][117][118][119]123,[125][126][127][128][129][130][131][132][133][134][135][136][137][138][139][140][141] …”

Section: Follow-up and Reducing Risk For Future Skin Cancersunclassified

Guidelines of care for the management of basal cell carcinoma

Baum¹,

Bordeaux²,

Brown³

et al. 2018

Journal of the American Academy of Dermatology

312

219

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Basal cell carcinoma (BCC) is the most common form of human cancer, with a continually increasing annual incidence in the United States. When diagnosed early, the majority of BCCs are readily treated with office-based therapy, which is highly curative. In these evidence-based guidelines of care, we provide recommendations for the management of patients with BCC, as well as an in-depth review of the best available literature in support of these recommendations. We discuss biopsy techniques for a clinically suspicious lesion and offer recommendations for the histopathologic interpretation of BCC. In the absence of a formal staging system, the best available stratification based on risk for recurrence is reviewed. With regard to treatment, we provide recommendations on treatment modalities along a broad therapeutic spectrum, ranging from topical agents and superficially destructive modalities to surgical techniques and systemic therapy. Finally, we review the available literature and provide recommendations on prevention and the most appropriate follow-up for patients in whom BCC has been diagnosed. ( J Am Acad Dermatol

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“…Comparatively large individual studies investigating this question include two local UK registry-based studies (6,7), a nationwide study in Finland (8), and a US prospective cohort study of health professionals (9), all of which showed significant increases in a range of cancers after NMSC. Another UK registrybased study, however, showed no such increased risks and indeed significant risk reductions in certain cancers, including of the breast and prostate (10).…”

Section: Introductionmentioning

confidence: 99%

Subsequent Primary Malignancies in Patients with Nonmelanoma Skin Cancer in England: A National Record-Linkage Study

Ong

Goldacre

Hoang

et al. 2014

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background: Conflicting evidence exists about whether people with a history of nonmelanoma skin cancer (NMSC) are at higher risk of subsequent primary malignant cancers than those without.Methods: An all England record-linked hospital and mortality dataset spanning from 1999 to 2011 was used. We constructed two cohorts: one that comprised people with a history of NMSC (502,490 people), and a control cohort that comprised people without. We "followed up" these two cohorts electronically to determine observed and expected numbers of people with subsequent primary cancers in each, based on person-years at risk, and calculated standardized risk ratios (RR).Results: Comparing the NMSC cohort with the non-NMSC cohort, the RR for all subsequent malignant cancers combined was 1.36 [95% confidence interval (CI), 1.35-1.37]. Significantly increased RRs (P < 0.05) were found for 26 of the 29 cancer types studied, in particular for salivary gland, melanoma, bone, and upper gastrointestinal tract cancers. The RRs were also particularly high when comparing younger people with and without NMSC.Conclusions: NMSC is strongly associated with a broad spectrum of other primary cancers, particularly in younger age groups. The pattern suggests a genetic or early-acquired etiologic association.Impact: These results represent what can be done using very large, linked, routinely collected administrative datasets; but such datasets lack detail. Further work to establish the mechanisms behind these associations is warranted. Cancer Epidemiol Biomarkers Prev; 23(3); 490-8. Ó2014 AACR.

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Risk of a Second Primary Cancer after Non-melanoma Skin Cancer in White Men and Women: A Prospective Cohort Study

Cited by 61 publications

References 47 publications

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

History of Keratinocyte Carcinoma and Risk of Melanoma: A Prospective Cohort Study

Guidelines of care for the management of basal cell carcinoma

Subsequent Primary Malignancies in Patients with Nonmelanoma Skin Cancer in England: A National Record-Linkage Study

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