Risk-management tool for environmental prioritization of pharmaceuticals based on emissions from hospitals

Zillien, Caterina; Loon, Cornelis van; Gülpen, Marijn; Tipatet, Kevin Saruni; Hanssen, Birgit; Beeltje, Henry; Roex, Erwin; Oldenkamp, Rik; Posthuma, Leo; Ragas, A.M.J.

doi:10.1016/j.scitotenv.2019.133733

Cited by 11 publications

(2 citation statements)

References 29 publications

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“…Pharmaceutical concentrations were obtained by passive sampling. Passive sampling is a costefficient environmental monitoring technique for long-term on-site pollutant monitoring [39,40,41,42,43,44]. The passive sampling technique and its methods had been subjected to extensive testing compared to traditional sampling [45,46,47,48,49].…”

Section: Methodsmentioning

confidence: 99%

Health risk-based prioritization approaches of pharmaceuticals in the Upper Citarum River Basin

Utami

Salami

Geerling

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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Two methods were developed to prioritize human health risks of pharmaceuticals based on defined daily doses (DDDs) obtained from the WHO and acute toxicity data on pharmaceuticals (TDLo) obtained from the PubChem database. A major advantage of these methods is that it requires no acceptable daily intake (ADI), reference dose (RfD), or tolerable daily intake (TDI) values, which are often unavailable or difficult to obtain for pharmaceuticals group. Both methods were applied to prioritize 16 pharmaceuticals detected by passive samplers in the water source of Ciwalengke Village, a peri-urban area in the Upper Citarum River Basin. Ten out of 16 pharmaceuticals could be prioritized by using both methods. The risk indicator values (RIhum) showed good agreement between the two approaches, especially for Caffeine and Trimethoprim. The priority ranking of Caffeine and Lidocaine were always in the top 3 highest human health risks. The ranking comparison showed considerable consistency, indicating that both prioritization methods are reasonably in line with each other. The pharmaceutical intake through the exposure of contaminated river water was expected to pose negligible human health risks (i.e. RIhum < 1) but can be refined more by conducting supplementary effects studies for other individual pharmaceuticals or pharmaceuticals mixtures.

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Section: Methodsmentioning

confidence: 99%

Health risk-based prioritization approaches of pharmaceuticals in the Upper Citarum River Basin

Utami

Salami

Geerling

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

View full text Add to dashboard Cite

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“…Because the measured environmental concentrations (MECs) are relatively low, at ng/L to μg/L levels, the determination of MECs requires advanced analytical techniques and expensive analytes, which may limit large‐scale monitoring and the resulting prioritizations in developing countries. As illustrated in Figure 1C and the Supporting Information, Table S1, prioritizations have been primarily conducted in Europe (e.g., United Kingdom, France, German, Switzerland, Spain, Italy, Greece, and Turkey; Alygizakis et al, 2020; Casado‐Martinez et al, 2018; Hinnenkamp et al, 2019; Ibanez et al, 2021; Riva et al, 2015; Sangion & Gramatica, 2016a, 2016b; Schoenaers et al, 2016; Smital et al, 2013; Vergili et al, 2019; Zhou et al, 2019; Zillien et al, 2019), North America (United States and Canada; Deere et al, 2021; Nallani et al, 2016), and East Asia (China, Korea, and Japan; Choi et al, 2021; Guo et al, 2021; He et al, 2020; Li et al, 2019; Park et al, 2018; Yu et al, 2019). The occurrence and distribution of PPCPs in other regions of the world have been poorly studied (despite some attempts; Dos Santos & Nardocci, 2019; Mansour et al, 2016).…”

Section: What Is Our Understanding Of Ppcps and Approaches For Priori...mentioning

confidence: 99%

What Approaches Should be Used to Prioritize Pharmaceuticals and Personal Care Products for Research on Environmental and Human Health Exposure and Effects?

Guo

Iwata

et al. 2022

Enviro Toxic and Chemistry

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Pharmaceuticals and personal care products (PPCPs) are released from multiple anthropogenic sources and thus have a ubiquitous presence in the environment. The environmental exposure and potential effects of PPCPs on biota and humans has aroused concern within the scientific community and the public. Risk assessments are commonly conducted to evaluate the likelihood of chemicals including PPCPs that pose health threats to organisms inhabiting various environmental compartments and humans. Because thousands of PPCPs are currently used, it is impractical to assess the environmental risk of all of them due to data limitations; in addition, new PPCPs are continually being produced. Prioritization approaches, based either on exposure, hazard, or risk, provide a possible means by which those PPCPs that are likely to pose the greatest risk to the environment are identified, thereby enabling more effective allocation of resources in environmental monitoring programs in specific geographical locations and ecotoxicological investigations. In the present review, the importance and current knowledge concerning PPCP occurrence and risk are discussed and priorities for future research are proposed, in terms of PPCP exposure (e.g., optimization of exposure modeling in freshwater ecosystems and more monitoring of PPCPs in the marine environment) or hazard (e.g., differential risk of PPCPs to lower vs. higher trophic level species and risks to human health). Recommended research questions for the next 10 years are also provided, which can be answered by future studies on prioritization of PPCPs. Environ Toxicol Chem 2022;00:1–14. © 2022 SETAC

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New Insights into the Occurrence of Micropollutants and the Management and Treatment of Hospital Effluent

Verlicchi

2020

The Handbook of Environmental Chemistry

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Risk-management tool for environmental prioritization of pharmaceuticals based on emissions from hospitals

Cited by 11 publications

References 29 publications

Health risk-based prioritization approaches of pharmaceuticals in the Upper Citarum River Basin

Health risk-based prioritization approaches of pharmaceuticals in the Upper Citarum River Basin

What Approaches Should be Used to Prioritize Pharmaceuticals and Personal Care Products for Research on Environmental and Human Health Exposure and Effects?

New Insights into the Occurrence of Micropollutants and the Management and Treatment of Hospital Effluent

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