“Risk is in the air”: Polycyclic aromatic hydrocarbons, metals and mutagenicity of atmospheric particulate matter in a town of Northern Italy (Respira study)

Feretti, Donatella; Pedrazzani, Roberta; Ceretti, Elisabetta; Grande, Mario Dal; Zerbini, Ilaria; Viola, Gaia Claudia Viviana; Gelatti, Umberto; Donato, Francesco; Zani, Claudia

doi:10.1016/j.mrgentox.2018.11.002

Cited by 35 publications

(32 citation statements)

References 79 publications

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“…Numerous in vitro studies highlighted the role of ultrafine particulate in the MN onset. Feretti et al [65] observed that PM 0.5 collected in an industrialized town of northern Italy exhibited the highest genotoxic potential compared with greater fractions inducing an increase of MN frequency in Allium root cells. In Verma et al [66], both PM 0.56 and PM 0.056 displayed MN formation in cells from clonal mouse embryo cell line (10T1/2) with greater effect as compared with larger PM fraction.…”

Section: Discussionmentioning

confidence: 99%

Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)

Panìco

Grassi

Bagordo

et al. 2020

IJERPH

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Micronuclei (MN) are biomarkers of early biological effect often used for detecting DNA damage in human population exposed to genotoxic agents. The aim of this study was to evaluate the frequency of MN in exfoliated buccal cells of children living in an industrialized (impacted) area compared with that found in children living in a control area without significant anthropogenic impacts. A total of 462 6–8-year-old children (206 in the impacted area, 256 in the control area) attending primary school were enrolled. A questionnaire was administered to the parents of the recruited children to obtain information about personal data, lifestyles, and food habits of their children. Atmospheric particulate fractions were collected near the involved schools to assess the level of environmental exposure of the children. The presence of MN was highlighted in 68.4% of children living in the impacted area with a mean MN frequency of 0.66‰ ± 0.61‰. MN positivity and frequency were significantly lower in the control area (37.1% and 0.27‰ ± 0.43‰, respectively). The frequency of MN was positively associated with quasi-ultrafine particulate matter (PM0.5), traffic near the home, and consuming barbecued food; while adherence to the Mediterranean diet and practicing sport were negatively associated.

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Section: Discussionmentioning

confidence: 99%

Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)

Panìco

Grassi

Bagordo

et al. 2020

IJERPH

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“…A study conducted in Italy [23] observed PM10 and PM2.5 at six sites of a town to be in the range of 41. . A Netherland-based study [26] concluded black smoke and NO 2 concentration to higher near motorways.…”

Section: Discussionmentioning

confidence: 99%

Public Health Threat Assessment of Vehicular Load Index-Induced Urban Air Pollution Indices Near Traffic Intersections In Central India

Gumashta

Bijlwan

2020

Cureus

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Objectives: To assess traffic vehicular load, levels of various air pollutants, their correlation at selected traffic intersections of Bhopal city and to suggest suitable public health measures. Methods: A transverse study was conducted by convenience sampling with equated distribution among vehicular load-based large (Group1:G1: 10 TI), medium (Group2:G2: 5 TI), and small (Group3:G3: 5 TI) traffic-intersections (TI) through a systematic stratified random selection of study sites to assess traffic vehicle load index (VLI).

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“…Polycyclic aromatic hydrocarbons (PAHs), aromatic amines, acridine dye, phenolic and polychlorinated compounds are well known cytotoxic and genotoxic agents causing mitotic inhibition and various kinds of chromosomal aberrations in A. cepa cells and different types of point mutations in the Ames Salmonella/microsome assay [47,48,49,50,51]. In detecting the presence of PAHs as pollutants in any tested samples, A. cepa uses its ethoxyresoru n-O-deethylase (EROD), a subunit of dependent mixed function oxidases of cytochrome P450-(CYP-).…”

Section: Discussionmentioning

confidence: 99%

Screening of Asa River water in Ilorin, Kwara State, Nigeria for available pollutants and its effects on mitosis and chromosomes morphology in Allium cepa cells

Akinboro

Aina

Rufai

et al. 2020

Preprint

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Improper disposal of wastes as an environmental problem is common in African and other developing countries of the world, and it raises concerns due to its potential threats to the life of organisms in both terrestrial and aquatic ecosystems. In this study, Asa River in Ilorin, Nigeria was evaluated for cytogenotoxicity at 25.0 %, 50.0 %, 100.0 % following the Allium cepa assay. Water samples were collected from three points tagged A, B, C, and each point was 500 m apart from each other. The water samples were used to grow A . cepa for microscopic and macroscopic toxicities screenings. Heavy metals and volatile organic pollutants in the water were elucidated following the Atomic Absorption Spectroscopy and Gas Chromatography-Mass Spectroscopy. The Water samples induced higher mitotic index values, except the sample C which induced smaller mitotic index value than the negative control. Root growth in the exposed A . cepa was significantly promoted at 25.0 % of the water samples, while significant reduction was obtained at 50.0 % and 100.0 % of the sample C, and 100.0 % of the sample A. The absolute water sample A induced highest percentage chromosomal aberrations, as the water samples B and C induced higher percentage chromosomal aberration than the negative control. Cadmium was detected at a concentration higher than its permissible limit in drinking water unlike Zinc, Iron, Manganase. Poly aromatic hydrocarbons, Aromatic amines, Acridine dye, Phenolic and Polychlorinated compounds were detected in the water sample. These pollutants may be responsible for the observed proliferative, inhibitory, cytotoxic and genotoxic effects of the water samples on A . cepa cells. Our results suggest that Asa River is polluted, having potential to inflict different adverse effects on human, animals and plants utilizing it along its course.

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“Risk is in the air”: Polycyclic aromatic hydrocarbons, metals and mutagenicity of atmospheric particulate matter in a town of Northern Italy (Respira study)

Cited by 35 publications

References 79 publications

Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)

Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)

Public Health Threat Assessment of Vehicular Load Index-Induced Urban Air Pollution Indices Near Traffic Intersections In Central India

Screening of Asa River water in Ilorin, Kwara State, Nigeria for available pollutants and its effects on mitosis and chromosomes morphology in Allium cepa cells

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