Risk genotypes and haplotypes of the GLUT1 gene for type 2 diabetic nephropathy in the Tunisian population

Abstract

The GLUT1 gene confers susceptibility to DN in type 2 diabetes patients in the Tunisian population.

Association of XbaI <i>GLUT</i>1 Polymorphism with Susceptibility to Type 2 Diabetes Mellitus and Diabetic Nephropathy

“…We did not find GG genotype in any of the studied subgroups. This was quite different from other studies [9] [10] [13] [14]. Variation in XbaI polymorphism genotype frequencies in healthy population is noted among different ethnicities for example the frequency of T allele in British Caucosid [15] was more than twice that reported in Chinese (51% in former and 21% in latter) [10], taken into consideration that both studies did not deviate from Hardy-Weinberg equilibrium.…”

“…Over the past years, conflicting results were reported from different studies concerning the association of GLUT1 Xba polymorphism and DN in type 2 diabetic patients [9] [10] [13] [14] as well as in type 1 diabetic patients [15] [21] [22]. The non significant association of the XbaI polymorphism of GLUT1 gene with DN found in the present study was in agreement with studies done in T2DM in Caucasian Mediterranean population [23] and in Tunisians [14]. Also in type 1 DM no significant association of the XbaI polymorphism with DN was reported in Danish population [21].…”

SLC2A1 Tag SNPs in Greek Patients with Diabetic Retinopathy and Nephropathy

“…Apart from this, XbaI(−) is possibly associated with a more severe form of T2DM, that leads to the development of DN in the Greek population [21]. On the other hand, there are studies that reveal a negative correlation between Xbal and DN in Spanish [19], Tunisian [22], Egyptian [23], and American [24] patients with T2DM. HaeIII (rs1385129) was found to be a risk factor for DN in Kurdish [25] and Tunisian [22] patients with T2DM.…”

“…HaeIII (rs1385129) was found to be a risk factor for DN in Kurdish [25] and Tunisian [22] patients with T2DM. HpyCH4V (rs710218) was reported to not influence the development of DN in T2DM Tunisians [22]. A relationship between enhancer-2 SNP 1 (Enh2-1 [rs841847]) and DN was revealed in T2DM Tunisians [22].…”

“…On the other hand, there are studies that reveal a negative correlation between Xbal and DN in Spanish [19], Tunisian [22], Egyptian [23], and American [24] patients with T2DM. HaeIII (rs1385129) was found to be a risk factor for DN in Kurdish [25] and Tunisian [22] patients with T2DM. HpyCH4V (rs710218) was reported to not influence the development of DN in T2DM Tunisians [22].…”