Risk for second primary non-breast cancer in pre- and postmenopausal women with breast cancer not treated with chemotherapy, radiotherapy or endocrine therapy

Langballe, Rikke; Olsen, Jørgen H.; Andersson, Michael; Mellemkjær, Lene

doi:10.1016/j.ejca.2011.01.004

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…This association might be related to germline mutations in BRCA1/2 genes, which increase the risk of both types of cancer [54], or to shared reproductive or environmental risk factors [55,56]. Moreover, it has been reported that an excess risk for second cancers remains in pre-menopausal women with breast cancer having not received any treatment [57]. By contrast, in postmenopausal women, the overall increased risk of second cancers with respect to the general population was lower when compared to premenopausal women.…”

Section: Discussionmentioning

confidence: 90%

“…Only few of the studies evaluated the effect of treatment on the risk of second tumours [13,17,18,38,40], although the treatment modalities were not comparable among the studies. There are several studies exploring the effect of different breast cancer treatment strategies on second cancer risk [19,57], but it was not possible to combine them for the same reasons. Consequently, more studies investigating this issue are warranted.…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

Risk of second cancers cancer after a first primary breast cancer: A systematic review and meta-analysis

Molina‐Montes

Requena

Sánchez‐Cantalejo

et al. 2015

Gynecologic Oncology

101

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Risk of second cancers cancer after a first primary breast cancer: A systematic review and meta-analysis

Molina‐Montes

Requena

Sánchez‐Cantalejo

et al. 2015

Gynecologic Oncology

101

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“…It has been proven that individuals who develop a malignancy might be at a greater risk of developing a second. On the one hand, the agents or factors that caused the first malignancy may still be at work, while on the other, chemotherapy and radiotherapy used in cancer treatment are known carcinogens 3, 4, 5, 6. The mechanisms require further exploration.…”

Section: Discussionmentioning

confidence: 99%

Use of microwave ablation in the treatment of patients with multiple primary malignant tumors

Han

Shao

et al. 2017

Thoracic Cancer

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A 56‐year‐old man was admitted to our hospital in 2007, complaining of an irritating cough. Computed tomography examination demonstrated a mass in the right lung and enlargement of the hilar and mediastinal lymph nodes. Small cell lung cancer was confirmed by pathological examination after fibro‐bronchoscope biopsy. The patient was treated with received sequential chemotherapy and radiotherapy. Preventive radiotherapy of the whole brain was performed after complete remission of the lung disease. Seven years after diagnosis, follow‐up computed tomography revealed masses in both the liver and kidney. Subsequent percutaneous biopsy confirmed hepatocellular carcinoma in the liver and renal clear cell carcinoma in the kidney. The patient received microwave ablation for the treatment of both liver and renal tumors, and is doing well with no recurrence after two years of follow‐up.

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“…Moreover, in postmenopausal women the risk of cervical cancer was significantly reduced. The authors speculated that these observations resulted from intensified screening in comparison to the general population, and are related to different lifestyle factors and socioeconomic status [25]. In the studied group, 60.2% of women (213 of 354) were premenopausal at diagnosis of breast cancer, while 46.3% (164 of 354) were younger than 50 years of age.…”

Section: Discussionmentioning

confidence: 99%

“…Published data indicate that age as well as menopausal status at diagnosis of breast cancer are important predictors of second primaries [16,[24][25][26][27][28][29][30][31][32][33][34]. Langballe et al, who investigated the risk of second malignancies in relation to menopausal status in women with breast cancer, noted that premenopausal women had an 18% increase in risk of appearance of second malignancy and this increased risk was confined to endometrial and ovarian cancers.…”

Section: Discussionmentioning

confidence: 99%

The characteristics of breast cancer patients with metachronous primary malignancies

Sas-Korczyńska¹,

Kamzol²,

Kołodziej-Rzepa³

et al. 2017

Nowotwory. Journal of Oncology

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Introduction. The risk of developing subsequent primary cancers varies from 1% to 18% and it depends on the type of first cancer and treatment methods applied. Considering the time of occurrence, multiple primary cancers generally fall into two categories: synchronous and metachronous. In breast cancer patients, 10.5% developed multiple primary cancers, from which 23.8% had synchronous, 79% had metachronous and the remaining 2.8% had both synchronous and metachronous malignancies. In patients with breast cancer, elevated risk is observed especially in the development of contralateral breast cancer, endometrial cancer, esophageal cancer, ovarian cancer and thyroid cancer. Aim. This paper presented the characteristics of breast cancer patients with metachronous primary malignancies in relation to the type of metachronous primaries (breast versus non-breast) and to analyse the impact of the type of metachronous cancers on survival rate. Material and methods. Among patients treated for breast cancer between 1963 and 2010, 354 patients (2.1%) developed metachronous primary malignancies and these made up 13.8% of all patients with multiple primary cancers. The mean age at diagnosis of the first breast cancer was 53 ± 11.5 years; positive family cancer history was noted in 127 patients (35.9%). Metachronous malignancies are defined as primaries following the diagnosis of breast cancer in a time interval greater than or equal to than 6 months. In our group, the mean time interval between the diagnosis of breast cancer and the appearance of metachronous malignancies was 100.9 ± 74.9 months (range: 6-543 months, median: 83 months). For comparison of the two groups (patients with second breast vs non-breast cancer) we used the Pearson's Chi-square test for independence (for categorized variables) and variance analysis with Student's t-test (for continuous variables). The survival rate was evaluated with the Kaplan-Meier method, and the log rank test was applied to assess the influence of some factors on the evaluated results. The significance level at α = 0.05 was adopted for all statistical analyses. Results. The probability of occurrence of new cancer averaged from 38.1% to 67.8% for 5 and 10 years after diagnosis of first breast cancer, respectively. In our group, 380 cases of metachronous carcinomas were noted in 354 analysed patients. The most frequent metachronous malignancy was breast cancer (194 cases -54.8%), which occurred as second (192 cases) or third (2 cases) cancer. Patients with contralateral breast cancer in comparison to other types of metachronous malignancies were significantly (p < 0.05): younger (under 50 years: 56.2% vs 34.4%), premenopausal (69.6% vs 48.8%), had a lobular type of first breast cancer (6.7% vs 1.3%), and rarely received tamoxifen (25.3% vs 48.2%). The type of metachronous cancers significantly influenced survival rate: 10-year overall survival rates were 80.1% vs 67.8%, (p = 0.0271). Conclusions. The risk of occurrence of second malignancies in breast cancer survivors makes early dete...

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Risk for second primary non-breast cancer in pre- and postmenopausal women with breast cancer not treated with chemotherapy, radiotherapy or endocrine therapy

Cited by 16 publications

References 21 publications

Risk of second cancers cancer after a first primary breast cancer: A systematic review and meta-analysis

Risk of second cancers cancer after a first primary breast cancer: A systematic review and meta-analysis

Use of microwave ablation in the treatment of patients with multiple primary malignant tumors

The characteristics of breast cancer patients with metachronous primary malignancies

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