Risk for postterm delivery after previous postterm delivery

Kistka, Zachary; Palomar, Lisanne; Boslaugh, Sarah; DeBaun, Michael R.; DeFranco, Emily; Muglia, Louis J.

doi:10.1016/j.ajog.2006.10.873

Cited by 63 publications

(47 citation statements)

References 31 publications

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“…A study from Scotland published in 2010 demonstrate increase risk of still birth as pregnancy advances especially after 39 weeks of gestation. 8 Aspiration of meconium during intrauterine life may result in meconium aspiration syndrome, is a leading cause of perinatal death as reported by Kistka et al 9 The rate of meconium aspiration and neonatal academia both increases as term pregnancies progress beyond 38 weeks by Bruckner et al 10 Mannino F et al also observed in their study that the still birth rate is lowest at 40 weeks and gradually increases as pregnancy advanced.…”

Section: Discussionmentioning

confidence: 49%

The study of maternal and perinatal outcome in prolonged pregnancy

Singh

Gupta

Verma

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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Background: Prolonged pregnancy or post-dated pregnancy is that pregnancy which has exceeded duration considered to be upper limit of normal pregnancy that is above 40 completed weeks or 280 days from the first day of last menstrual period. The objective was to evaluate the maternal and perinatal outcome of post-dated pregnancy.Methods: A prospective case control study was conducted on antenatal women for 18 months period from May 2014- October 2015 admitted to the Obstetrics and Gynecology Department, Era’s Lucknow Medical College and Hospital, Lucknow, Uttar Pradesh, India. The study group was comprised of antenatal women having pregnancy beyond 40 weeks, and the control group was represented with antenatal women between 37-40 weeks admitted for delivery during this period.Results: The prevalence of post-dated pregnancy was found to be 17.6% and of post-term was 5.69%. Among post-dated subjects LSCS rate was 56.50% and in term (37-40 weeks) patient it was 34.18%. The NICU admission for birth asphyxia was 6.09% among term (37-40 weeks) patients and 17.6% in post-dated pregnancies.Conclusions: Any pregnancy that crosses expected date of delivery, Foetal well-being must be assessed and induction of labour should be considered to decrease the risk of perinatal morbidity and mortality.

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Section: Discussionmentioning

confidence: 49%

The study of maternal and perinatal outcome in prolonged pregnancy

Singh

Gupta

Verma

et al. 2017

Int J Reprod Contracept Obstet Gynecol

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“…Additionally, many individuals for whom we could not verify precise gestational ages were reported as 'full term' and assigned gestational age of 40 weeks. While this is the most likely gestational age for infants to be born [6] , we may lose some variability in the overall distribution of gestational age by doing so. As modeling of trait variance is essential to segregation analysis, this approach also may have affected our results.…”

Section: Discussionmentioning

confidence: 99%

“…For example, birth timing is highly consistent across pregnancies in the same woman [4][5][6][7][8][9] . Moreover, the most likely age for a recurrent preterm birth to a given mother is the same week as the first preterm birth [6,9,10] suggesting that factors that are stable over time, such as genetics, affect birth timing. Additionally, mothers and daughters [11] , and sisters [9] share risk for delivering preterm.…”

mentioning

confidence: 99%

Mother’s Genome or Maternally-Inherited Genes Acting in the Fetus Influence Gestational Age in Familial Preterm Birth

Plunkett

Feitosa²,

Trusgnich

et al. 2009

Hum Hered

Self Cite

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Objective: While multiple lines of evidence suggest the importance of genetic contributors to risk of preterm birth, the nature of the genetic component has not been identified. We perform segregation analyses to identify the best fitting genetic model for gestational age, a quantitative proxy for preterm birth. Methods: Because either mother or infant can be considered the proband from a preterm delivery and there is evidence to suggest that genetic factors in either one or both may influence the trait, we performed segregation analysis for gestational age either attributed to the infant (infant’s gestational age), or the mother (by averaging the gestational ages at which her children were delivered), using 96 multiplex preterm families. Results: These data lend further support to a genetic component contributing to birth timing since sporadic (i.e. no familial resemblance) and nontransmission (i.e. environmental factors alone contribute to gestational age) models are strongly rejected. Analyses of gestational age attributed to the infant support a model in which mother’s genome and/or maternally-inherited genes acting in the fetus are largely responsible for birth timing, with a smaller contribution from the paternally-inherited alleles in the fetal genome. Conclusion: Our findings suggest that genetic influences on birth timing are important and likely complex.

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“…These studies further suggest that polymorphisms associated with genes important for connective tissue synthesis and metabolism may predispose women to preterm birth due to cervical insufficiency or preterm premature rupture of membranes. On the other end of the spectrum, the failure to activate genes important in connective tissue remodeling could be an underlying cause of postterm pregnancies due to failure of cervical remodeling (Kistka et al 2007). Another important similarity between mouse and human at this stage of remodeling is the fact that these changes occur during a period in which the P 4 to E 2 ratio is high in both species, thus hormonal regulation of these processes may be conserved.…”

Section: Relevance To Cervical Remodeling In Womenmentioning

confidence: 99%

Cervical remodeling in term and preterm birth: insights from an animal model

Mahendroo¹

2012

Reproduction

170

145

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Proper cervical function is essential for a normal pregnancy and birth to occur. Understanding the mechanisms that take place in normal pregnancy will allow a better comprehension of the complications involved in premature cervical remodeling and lead to better methods of diagnostics and prevention for preterm birth. Unfortunately, human samples are not easily available, and samples that are collected are often confounded by variations in timing and region of cervix from which sample is collected. Animal models, specifically the mouse, have facilitated a great deal of exploration into the mechanisms of cervical function and pathways of preterm birth. This review highlights some of the groundbreaking discoveries that have arisen from murine research including 1) the identification of early pregnancy changes in collagen fibril processing and assembly that result in progressive modifications to collagen architecture with subsequent loss of tissue stiffness during pregnancy, 2) the determination that immune cells are not key to cervical ripening at term but have diverse phenotypes and functions in postpartum repair, and 3) the finding that the process of preterm cervical ripening can differ from term ripening and is dependent on the etiology of prematurity. These findings, which are relevant to human cervical biology, provide new insights that will allow targeted studies on the human cervix as well as identify potential biomarkers for early detection of premature cervical ripening and development of improved therapies to prevent premature ripening of the cervix and subsequent preterm birth.

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Risk for postterm delivery after previous postterm delivery

Cited by 63 publications

References 31 publications

The study of maternal and perinatal outcome in prolonged pregnancy

The study of maternal and perinatal outcome in prolonged pregnancy

Mother’s Genome or Maternally-Inherited Genes Acting in the Fetus Influence Gestational Age in Familial Preterm Birth

Cervical remodeling in term and preterm birth: insights from an animal model

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