Risk for Obstructive Sleep Apnea by Berlin Questionnaire, But Not Daytime Sleepiness, Is Associated With Resistant Hypertension: A Case-control Study

Gus, Miguel; Gonçalves, Sandro Cadaval; Martinez, Dênis; Silva, Erlon O. de Abreu; Moreira, Leila Beltrami; Fuchs, Sandra Cristina Pereira Costa; Fuchs, Flávio Danni

doi:10.1038/ajh.2008.184

Cited by 90 publications

(63 citation statements)

References 23 publications

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“…The BQ includes questions on obesity, hypertension, snoring, daytime sleepiness and fatigue 17 . We demonstrated that a positive response to the questionnaire was independently associated with resistant hypertension 18 .…”

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confidence: 75%

“…Patients with OSA had a greater recurrence rate of atrial fibrillation after catheter arrhythmia ablation than patients without OSA. The prevalence of a high risk factor of coronary artery disease associated with OSA identified by the BQ was 80% in patients with resistant hypertension versus 44% in patients with controlled hypertension 18 . Drager et al 42 found similar performance of the BQ in the hypertensive population.…”

Section: Controls Casesmentioning

confidence: 93%

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Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

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Obstructive sleep apnea (OSA), a risk factor for coronary artery disease, remains under diagnosed. We investigated if OSA identified by the Berlin Questionnaire (BQ) is associated with the risk of coronary artery disease. Cases were patients referred for elective coronariography. The cases were classified with significant coronary lesions (stenosis > 50% in an epicardial coronary) or without significant coronary lesions. Controls were selected from a population-based sample. Positive BQ results were identified in 135 (41.2%) of 328 cases, in contrast with 151 (34.4%) of 439 control subjects (p = 0.03). In a multinomial logistic analysis, the risk for OSA identified by the BQ was independently associated with coronary artery disease in cases with lesions of at least 50% (OR = 1.53; 95%CI: 1.02-2.30; p = 0.04). The risk from OSA identified by the BQ was higher in younger subjects (40-59 years) (OR = 1.76; 95%CI: 1.05-2.97; p = 0.03) and in women (OR = 3.56; 95%CI: 1.64-7.72; p = 0.001). In conclusion, OSA identified by the BQ greatly increases the risks of coronary artery disease in patients having significant coronary artery lesions indicated by anangiogram, particularly in younger individuals and in women.

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confidence: 75%

Section: Controls Casesmentioning

confidence: 93%

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

et al. 2012

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“…The Berlin Questionnaire (BQ), one of the most widely used screening tools, has been validated as a predictor of OSA in the primary care setting 24 and is now commonly used to assess need for PSG. [24][25][26][27][28] It has, however, not performed as well in the general surgery population, 23,27 and its utility in the bariatric surgery population is unproven. Given that "obesity" is an indicator of increased OSA risk per the BQ scoring scheme, the discriminatory ability of the BQ may be worse among bariatric surgery patients, all of whom are obese.…”

Section: Assessment Of Obstructive Sleep Apnea In Adults Undergoingmentioning

confidence: 99%

Assessment of Obstructive Sleep Apnea in Adults Undergoing Bariatric Surgery in the Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) Study

Khan

King

Patterson

et al. 2013

Journal of Clinical Sleep Medicine

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“…Despite these limitations, our results indicate the major importance of the complex evaluation of nearly 20 ambulatory BP variables selected by comparison with cardiorespiratory indices obtained during parallel PSG examination. Recent results have indicated that an increased risk for SAHS is highly prevalent when assessed by a special Berlin questionnaire, and it is frequently associated with resistant hypertension [38]. ABPM should be evaluated in patients with hypertension to assess and prevent risk of morbidity and mortality [39].…”

Section: 1mentioning

confidence: 99%

Blood pressure increase detected by ambulatory monitoring correlates with hypoxemia reflecting sleep apnea severity

et al. 2009

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AbstractAmbulatory blood pressure monitoring and parallel polysomnographic study were performed in 116 adult males divided into 6 groups. Thirty blood-pressure (BP) and polysomnographic variables were measured to test their usefulness for screening for both arterial hypertension and sleep apnea-hypopnea syndrome (SAHS). The development of severe breathing disorders and hypoxemia during sleep was attributed to SAHS, when compared with measurements in healthy controls and in patients with arterial hypertension. Such disorders manifested as an increased apnea-hypopnea index, apnea index, duration of arterial oxygen saturation of less than 85%, and decrease of average arterial oxygen saturation that correlated with nocturnal average diastolic BP (p=0.0049, p=0.0027, p=0.049 and p=0.0457, respectively). These respiratory disorders resulted in various nocturnal, rather than diurnal, and diastolic and systolic BP variables. The acute antihypertensive effect of continuous positive airway pressure therapy for SAHS significantly reduced the episodes of apnea and hypopnea and the secondary component of hypertension caused by excessive sympathetic stimulation. For the SAHS-induced, dose-dependent component of hypertension that responded to continuous positive airway pressure, the following variables, in decreasing significance, were useful: nocturnal average systolic and diastolic BP and 24-hour average systolic and diastolic BP, as well as percent time elevation and mean blood pressure load. The monitoring of these variables could contribute to early diagnostic and prognostic stratification of complications and adequate therapy of the secondary component of hypertension caused by SAHS.

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Risk for Obstructive Sleep Apnea by Berlin Questionnaire, But Not Daytime Sleepiness, Is Associated With Resistant Hypertension: A Case-control Study

Abstract: High risk for OSAS assessed by the Berlin Questionnaire is highly prevalent and associated with resistant hypertension. This questionnaire may be used as screening for OSAS in patients with this clinical condition.

Cited by 90 publications

References 23 publications

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Obstructive sleep apnea, detected by the Berlin Questionnaire: an associated risk factor for coronary artery disease

Assessment of Obstructive Sleep Apnea in Adults Undergoing Bariatric Surgery in the Longitudinal Assessment of Bariatric Surgery-2 (LABS-2) Study

Blood pressure increase detected by ambulatory monitoring correlates with hypoxemia reflecting sleep apnea severity

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