2022
DOI: 10.7326/m22-0988
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Risk for Myocardial Infarction, Stroke, and Pulmonary Embolism Following COVID-19 Vaccines in Adults Younger Than 75 Years in France

Abstract: Severe cardiovascular events (myocardial infarction [MI], pulmonary embolism [PE], and stroke) have been reported after COVID-19 vaccination. In this French registry-based analysis of adults younger than 75 years, administration of the Pfizer–BioNTech or Moderna mRNA vaccine was not associated with increased risk for MI, PE, or stroke. However, recipients of the Oxford–AstraZeneca vaccine had greater risk for MI and PE in the second week after vaccination. A similar association for the Janssen adenoviral-based… Show more

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Cited by 39 publications
(42 citation statements)
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“…They have, for example, been recently successfully used to assess the risk of arterial and venous thromboembolic events with mRNA or adenoviral based COVID vaccines. [12][13][14] These results further stress the importance of conducting sensitivity analyses in pharmaco-epidemiological studies, which make it possible to assess the degree of variability in the results of a study according to the methodological choices made. Such sensitivity analyses must ideally be formalized a priori rationale to aid decisionmaker assessment and increase the utility of the findings.…”
Section: Discussionmentioning
confidence: 85%
See 1 more Smart Citation
“…They have, for example, been recently successfully used to assess the risk of arterial and venous thromboembolic events with mRNA or adenoviral based COVID vaccines. [12][13][14] These results further stress the importance of conducting sensitivity analyses in pharmaco-epidemiological studies, which make it possible to assess the degree of variability in the results of a study according to the methodological choices made. Such sensitivity analyses must ideally be formalized a priori rationale to aid decisionmaker assessment and increase the utility of the findings.…”
Section: Discussionmentioning
confidence: 85%
“…Given the difficulty to identify nonvaccinated‐noninfected groups for which the exchangeability assumption could be reasonably met, these designs could be a relevant alternative. They have, for example, been recently successfully used to assess the risk of arterial and venous thromboembolic events with mRNA or adenoviral based COVID vaccines 12–14 …”
Section: Discussionmentioning
confidence: 99%
“…Specifically, in Jcovden elderly recipients, the excess of ischemic stroke over Comirnaty is 106 SAEs/OMD, causing an excess of 10.5 deaths/OMD (37). A recent study, confirms that Vaxzevria and Jcovden vaccines are associated with myocardial infarction (relative incidence, 1.29 and 1.75, respectively), even if significance concerning the SAE due to Jcovden was not reached, probably due to the low number of vaccinations with Jcovden (50).…”
Section: Arterial Thrombosis In Recipients Of Adenovirus-based Vaccinesmentioning
confidence: 98%
“…An exception to the trend of VITT incidence is the virtual absence of VITT in the elderly with CVT or dying of CVT ( Figure 1B ) ( 37 ). One case report described the occurrence of non-VITT thrombosis in Jcovden recipients ( 50 ).…”
Section: Venous Thrombosis In Recipients Of Adenovirus-based Vaccinesmentioning
confidence: 99%
“…We searched Medline using the key words “death”, “deaths”, “COVID-19”, “vaccine” and “vaccination” to identify same-day fatalities after COVID-19 vaccinations. Six reports 5–12 contained demographic and autopsy data on 54 patients (38 males and 16 females, age range 23-94) fulfilling the scope of our search (Table 1).…”
mentioning
confidence: 99%