Risk factors, types and outcomes of arterial ischemic stroke in Polish pediatric patients: a retrospective single-center study

Abstract

Introduction: Various neurological complications may occur as a consequence of arterial ischemic stroke (AIS) and have an impact on daily activity of the patients, costs of their medical care and rehabilitation. The aim of this study was to analyze risk factors, stroke symptoms and post-stroke consequences in Polish pediatric patients depending on stroke subtype. Material and methods: We retrospectively reviewed 77 children under the age of 18 years following their first AIS. Patients were white, Polish Caucasians, recruited in the Department of Pediatric Neurology at the Medical University of Silesia in Katowice (Poland). Statistical analysis was performed using Statistica 12.0. Results: Gender differed significantly between stroke subgroups (p = 0.030). The presence of focal cerebral arteriopathy (FCA) and chronic diseases was associated with type of AIS (p = 0.003 and p = 0.050, respectively). An outcome without neurological deterioration (normal outcome) was observed in 43% of children with lacunar anterior circulation infarct (LACI). Hemiparesis was present in almost all children with total anterior circulation infarct (TACI), in two thirds of children with partial anterior circulation infarct (PACI) and in almost 50% of children with LACI or posterior circulation infarct (POCI). In every child with hemiplegia the stroke symptom evolved into hemiparesis at follow-up. Additionally, patients with a normal outcome were older at the time of AIS than those with at least one neurological consequence (OR = 0.894, p = 0.034). Conclusions: The presence and number of neurological outcomes depend on stroke subtypes. A relation between the presence of post-stroke deficits and age at onset was observed. The odds of deficit after ischemic stroke decreases by an average of 10.6% if the child is 1 year older at the time of AIS.

Risk Factors for Recurrent Arterial Ischemic Stroke in Children and Young Adults

“…As for the lower age limit, 15-year-old patients are often analyzed together with pediatric patients.The etiologic mechanisms of AIS occurring in adulthood and at a developmental age differ. Similarity may be found in the case of a significant predominance of the male sex, both in pediatric patients with AIS and in young adults with stroke [20][21][22]. However, some discrepancies have also been noted in this respect as Rasura et al [23] observed higher incidence rates for stroke in young females than in young males (8.4 vs. 7.6) among stroke patients from Rome.…”

Analysis of 622 paediatric hospitalisations due to arterial ischaemic stroke in Poland – National Health Fund registry-based study from 2011 to 2020

“…In patients from Katowice (Poland), AIS appeared most commonly in winter, with significant differences between types of AIS and seasons of the year during which the AIS occurred, i.e. TACI stroke occurred most frequently in the summer, LACI – during winter or spring, and PACI – winter or autumn [ 31 ].…”

Ischemic stroke in a pediatric patient – a case report

“…[7] Ze względu na zróżnicowaną etiologię, rozwój i konsekwencje udaru niedokrwiennego mogą być jednak wynikiem jednoczesnej obecności kilku powiązanych czynników ryzyka. [8] Jednym z nich jest wrodzona trombofilia. Badania sugerują, że czynniki prozakrzepowe można zidentyfikować u 20-50% dzieci z udarem niedokrwiennym, co znacznie przewyższa podobne obserwacje u osób dorosłych.…”