Risk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study

Lin, Ro-Ting; Chen, Pei‐Lung; Yang, Chi-Ying; Yeh, Chun-Chieh; Lin, Chung‐Yen; Chung, An‐Ko; Lin, Jaw–Town

doi:10.1186/s12876-022-02325-7

Cited by 5 publications

(6 citation statements)

References 48 publications

(45 reference statements)

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“…13 Nevertheless, either of these could not be identified in most patients with EOPC. 25 Despite the monogenic influence, a genetic risk of the disease is inclined to be polygenic manner. Regarding the genome-wide association studies, 6 novel single-nucleotide polymorphisms-including rs1381553 (T > A), rs3984967 (T > A), rs11257929 (T > G), rs12671911 (C > T), rs72718310 (T > A), and rs111703463 (G > A)-were discovered to be, albeit unknown function, associated with EOPC; these variants were, however, nonreplicable in other populations.…”

Section: Discussionmentioning

confidence: 99%

“…BRCA1/2 mutation and microsatellite instability—impairing tumor suppressor function and DNA mismatch repair, respectively—have been well-established abnormalities underpinning the disease's pathogenesis and perpetuation 13 . Nevertheless, either of these could not be identified in most patients with EOPC 25 . Despite the monogenic influence, a genetic risk of the disease is inclined to be polygenic manner.…”

Section: Discussionmentioning

confidence: 99%

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The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors

Danpanichkul,

Suparan,

Jaroenlapnopparat

et al. 2024

Pancreas

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Objectives Despite evidence of increased incidence of early-onset pancreatic cancer (EOPC), defined as pancreatic cancer diagnosed in patients below 50 years old, and its risk factors in the Western region, global epidemiological data addressing this issue is still lacking. Materials and Methods Utilizing data from the Global Burden of Disease Study 2019, we aimed to conduct a comprehensive analysis of the incidence, deaths, and disability-adjusted life years (DALYs) associated with EOPC and its risk factors, including smoking, obesity, and diabetes. The analysis examined the annual percentage change (APC) over the period. Results In 2019, the incidence of EOPC surpassed 35,000 cases worldwide. This burden of EOPC tends to be more prevalent in males, as well as in Europe and high SDI countries. However, there is a noticeable upward trend in the burden of EOPC in the Eastern Mediterranean. While there is a global decline in EOPC mortality attributed to smoking (APC −0.33%), there is a concerning increase in mortality associated with diabetes (APC +2.84%) and obesity (APC +2.12%). Conclusions The burden of EOPC has been increasing. The mortality is rising mainly from metabolic factors. There is an urgent need for national policy development for reducing the burden of this disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors

Danpanichkul,

Suparan,

Jaroenlapnopparat

et al. 2024

Pancreas

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“…This high rate may be partially explained by the WGS approach to examine a comprehensive list of 750 genes, diverse genetic variant types, and sequence information within non-coding regions. Our cohort was not considered to be of younger age (range, 36.1–82.5 years) or have a stronger family history ( Lin et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

“…This retrospective cohort study recruited inpatients diagnosed with PDAC (C25.0–C25.9, based on ICD-10) in a tertiary medical center in Taiwan; details are available in our previous publication ( Lin et al, 2022 ). We recruited 24 patients (men: 19; women: 5; median age at diagnosis: 56.7 years).…”

Section: Methodsmentioning

confidence: 99%

Diagnostic rate of germline pathogenic variants in pancreatic ductal adenocarcinoma patients using whole genome sequencing

et al. 2023

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Identification of germline pathogenic variants in cancer patients is critical for treatment planning, genetic counseling, and health policymaking. However, previous estimates of the prevalence of germline etiology of pancreatic ductal adenocarcinoma (PDAC) were biased because they were based only on sequencing data of protein-coding regions of known PDAC candidate genes. To determine the percentage of patients with PDAC carrying germline pathogenic variants, we enrolled the inpatients from the digestive health clinics, hematology and oncology clinics, and surgical clinics of a single tertiary medical center in Taiwan for whole genome sequencing (WGS) analysis of genomic DNA. The virtual gene panel of 750 genes comprised PDAC candidate genes and those listed in the COSMIC Cancer Gene Census. The genetic variant types under investigation included single nucleotide substitutions, small indels, structural variants, and mobile element insertions (MEIs). In 8 of 24 (33.3%) patients with PDAC, we identified pathogenic/likely pathogenic variants, including single nucleotide substitutions and small indels in ATM, BRCA1, BRCA2, POLQ, SPINK1 and CASP8, as well as structural variants in CDC25C and USP44. We identified additional patients carrying variants that could potentially affect splicing. This cohort study demonstrates that an extensive analysis of the abundant information yielded by the WGS approach can uncover many pathogenic variants that could be missed by traditional panel-based or whole exome sequencing-based approaches. The percentage of patients with PDAC carrying germline variants might be much higher than previously expected.

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“…The strongest risk factor for PC is age. The incidence of PC increases significantly after the age of 50 and over 80% of PCs are diagnosed in patients older than 60 [7] (Figure 5). Epidemiology and Risk Factors of Pancreatic Cancer DOI: http://dx.doi.org/10.5772/intechopen.109778…”

Section: Risk Factorsmentioning

confidence: 99%

Epidemiology and Risk Factors of Pancreatic Cancer

Molinari¹,

Líu²,

Kaltenmeier³

2023

Pancreatic Cancer- Updates in Pathogenesis, Diagnosis and Therapies

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Pancreatic cancer (PC) is among the most common tumors of the gastrointestinal system in the world. In the United States and in other industrialized countries, it represents the fourth leading cause of cancer-related mortality. The incidence of PC increases with age and most patients are diagnosed after the age of 50. The overall prognosis of PC is poor. Most tumors are silent and they often present when metastatic. Only less than 15% of patients can undergo surgery, which represents the only potential cure for PC, and less than 10% of patients are alive after 5 years. In this chapter, we present the epidemiology of PC and its most common risk factors.

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Risk factors related to age at diagnosis of pancreatic cancer: a retrospective cohort pilot study

Cited by 5 publications

References 48 publications

The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors

The Global Burden of Early-Onset Pancreatic Cancer and Its Risk Factors

Diagnostic rate of germline pathogenic variants in pancreatic ductal adenocarcinoma patients using whole genome sequencing

Epidemiology and Risk Factors of Pancreatic Cancer

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