Risk Factors Promoting Hypertensive Crises: Evidence From a Longitudinal Study

Saguner, Ardan M.; Dür, Stefan; Perrig, Martin; Schiemann, U.; Stuck, Andreas E.; Bürgi, U; Erné, Paul; Schoenenberger, Andreas W.

doi:10.1038/ajh.2010.71

Cited by 95 publications

(71 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…First, this study supports the need for BW reduction in overweight subjects to diminish their cardiovascular risk burden. [23][24][25][26][27][28] This study demonstrated that a BW reduction of approximately 10% led to a BP reduction similar to the previously reported reduction achieved with single-drug antihypertensive therapy. 29 Second, this study suggests that the mechanisms accounting for the relationship between weight and BP are still unclear.…”

Section: Discussionsupporting

confidence: 83%

Effects of weight on blood pressure at rest and during exercise

Schoenenberger

Schoenenberger-Berzins

Suter

et al. 2013

Hypertens Res

View full text Add to dashboard Cite

Body weight (BW) and blood pressure (BP) have a close relationship, which has been accounted for by hormonal changes. No previous study has evaluated the effect of wearing an external weight vest on BP to determine whether there is a simple mechanism between BW and BP. Seventeen healthy volunteers underwent weight reduction (WR) through caloric restriction. Before and after WR, BW, body fat percentage and BP at rest and during exercise were measured. Before and after WR, exercise testing was performed twice with the random allocation of a weight vest (10 kg) during one of the tests. Linear regression was used to detect independent associations between BP and the weight vest, BW and body fat percentage. BW decreased from 89.4 ± 15.4 kg to 79.1 ± 14.0 kg following WR (P<0.001). WR led to significant decreases in BP at rest (from 130.0/85.9 mm Hg to 112.5/77.8 mm Hg, P<0.001 for systolic and diastolic BPs) and during exercise. The weight vest significantly increased BP at rest (to 136.1/90.7 mm Hg before and 125.8/84.6 mm Hg after WR) and during exercise. Linear regression analysis identified an independent association between the weight vest and BP (P=0.006 for systolic BP and P=0.009 for diastolic BP at rest). This study demonstrates that wearing an external weight vest has immediate effects on BP at rest and during exercise independent of BW or body fat. More research is needed to understand the physiological mechanisms between weight and BP.

show abstract

Section: Discussionsupporting

confidence: 83%

Effects of weight on blood pressure at rest and during exercise

Schoenenberger

Schoenenberger-Berzins

Suter

et al. 2013

Hypertens Res

View full text Add to dashboard Cite

show abstract

“…One of the possible factors involved in the genesis of HC may have been the mismanagement of or non-compliance with antihypertensive treatment. [16][17][18] In our study, significantly more patients with HU compared with HE had previously received antihypertensive treatment, which reinforces this hypothesis.…”

Section: Discussionsupporting

confidence: 77%

“…Recently, Saguner et al 18 described several potential risk factors for HC in a sample of 85 hypertensive patients followed-up for 1.6 ± 0.3 years. The main risk factors were female gender, high degree of obesity, presence of hypertensive or coronary heart disease, somatoform disorder, higher number of antihypertensive drugs and non-adherence to treatment regimens.…”

Section: Discussionmentioning

confidence: 99%

Hypertensive crisis: clinical–epidemiological profile

et al. 2010

View full text Add to dashboard Cite

Hypertensive crisis (HC) stands out as one type of acute elevation in blood pressure (BP) and can manifest as hypertensive emergency (HE-with target-organ damage (TOD)) or hypertensive urgency (HU-without TOD), usually accompanied by levels of diastolic BP X120 mm Hg. The aim of this study was to characterize the clinical-epidemiological profile of HC over the course of 1 year in a university reference hospital and perform a review of the literature. The study was a cross-sectional study, conducted over a period of 1 year (2006) in 362 patients who presented for treatment at the emergency hospital with HC, as described above. Among all patients examined, 231 individuals met the criteria for HE and 131 met the criteria for HU. Patients with HE were older (Po0.001) and more sedentary (P¼0.026) than those with HU. Furthermore, fewer HE patients than HU patients had previously undergone antihypertensive treatment (P¼0.006). The groups did not differ regarding BP levels, gender, smoking or body mass index. Dyspnea (41.1%), thoracic pain (37.2%) and neurological deficit (27.2%) were common signs/symptoms in those with HE. Meanwhile, in the group with HU, we most frequently found headache (42.0%), thoracic pain (41.2%) and dyspnea (34.3%). Among the forms of HE, we most frequently observed acute lung edema (30.7%), myocardial infarction/unstable angina (25.1%), and ischemic (22.9%) and hemorrhagic (14.8%) stroke. HC is a clinical entity associated with high morbidity in the emergency room. Individuals with HE are older and sedentary and have lower rates of antihypertensive treatment. Adequate control of BP should be pursued as a way to avoid this severe complication of hypertension.

show abstract

“…Obesity and female sex have also been identified as risk factors for the development of hypertensive crises. 11 We propose that a combination of the two diagnoses of IIH and systemic hypertension led to an acceleration of visual loss and suggest that treating systemic hypertension without lowering raised intracranial pressure may compound a critical ischaemia at the level of the ciliary arterial circle. This circle is vulnerable to acute hypotension (and therefore perhaps a rapid decrease in blood pressure in a previously hypertensive patient), as it competes with the choroidal circulation.…”

Section: Discussionmentioning

confidence: 99%

Fulminant Idiopathic Intracranial Hypertension With Malignant Systemic Hypertension—A Case Report

Abbasi

Brady

Cooper

2013

Neuro-Ophthalmology

View full text Add to dashboard Cite

We describe a young woman who presented with malignant systemic hypertension and fulminant idiopathic intracranial hypertension. This is a rare combination, but both diagnoses should be considered in patients with optic disc swelling in whom cerebral imaging does not suggest an alternative cause. In this case, malignant hypertension was identified and treated before the idiopathic intracranial hypertension was recognised. Visual failure was evident at presentation and prior to blood pressure manipulation. It is likely that a combination of both conditions increased the vulnerability of the optic nerve head to ischaemic damage. It is also possible that reducing blood pressure in such patients, without treating coexisting raised intracranial pressure, may compound an already compromised ciliary arterial perfusion pressure. We therefore recommend careful blood pressure measurement in all patients presenting with idiopathic intracranial hypertension and advise that lumbar puncture is performed in patients with malignant hypertension with optic disc oedema, particularly in overweight young females.

show abstract

Risk Factors Promoting Hypertensive Crises: Evidence From a Longitudinal Study

Cited by 95 publications

References 34 publications

Effects of weight on blood pressure at rest and during exercise

Effects of weight on blood pressure at rest and during exercise

Hypertensive crisis: clinical–epidemiological profile

Fulminant Idiopathic Intracranial Hypertension With Malignant Systemic Hypertension—A Case Report

Contact Info

Product

Resources

About