Risk factors predicting upper urinary tract deterioration in patients with spinal cord injury: A retrospective study

Abstract

Abnormal radiological LUT findings, the absence of antimuscarinic drug usage, detrusor pressures ≥75 cmH O, and cystometric bladder capacity <200 ml were independent risk factors predicting UUT deterioration SCI patients. Neurourol. Urodynam. 36:653-658, 2017. © 2016 Wiley Periodicals, Inc.

Renal deterioration after spinal cord injury is associated with length of detrusor contractions during cystometry—A study with a median of 41 years follow‐up

“…Some studies support that an increased maximum detrusor pressure during filling increases the risk of UUT complications and renal deterioration, while other studies describe that an increased maximum detrusor pressure during voiding is a risk indicator of renal deterioration in SCI patients with neurogenic DO . The reported value of damaging voiding detrusor pressures vary from 75 to 115 cmH 2 O …”

“…Additionally, few studies have examined the association between urodynamic parameters and renal function. Previously, renal function has been investigated with effective renal plasma flow on renography, split renal function on renography, or serum‐creatinine measurements . In this study, we used split renal function by radioisotope renography and GFR by 51 Cr‐EDTA clearance, which are accurate methods that determine renal deterioration by use of a radio‐labeled tracer, and are not influenced by changes in muscle mass or inaccurate urine collection …”

“…The most cited study was conducted by McGuire et al in 1981 on 42 myelodysplastic children, stating that a vesical leak point pressure of 40 cmH 2 O or more increases the risk of vesicoureteral reflux and upper urinary tract (UUT) dilatation . Subsequently, several urodynamic parameters have been suggested as risk indicators of UUT complications in patients with SCI, including maximum detrusor pressure during filling, maximum detrusor pressure during voiding, bladder compliance, maximum bladder capacity, and length of detrusor contractions . Most of the studies examine the effect of urodynamic parameters on UUT complications like hydronephrosis, dilatation of the UUT and/or vesicoureteral reflux, but only few studies have investigated the association between urodynamic parameters and renal function .…”

Value of urodynamic findings in predicting upper urinary tract damage in neuro‐urological patients: A systematic review

“…Mean range of duration of neurological disease was 4‐30 years . Mean follow‐up ranged from 1 to 42 years.21,60 IC regimen was performed by 428 (56.7%) adults on treatment for their NLUTD (see Table ).…”

Remarkable points for discussing outcomes of urodynamic studies

“…I have taken a great interest in the recently published article entitled “Risk factors predicting upper urinary tract deterioration in patients with spinal cord injury: A retrospective study” by Çetinel et al However, I have a few remarks with respect to the methodology of the study.…”