Risk Factors, Patterns, and Distribution of Bone Metastases and Skeletal-Related Events in High-Risk Breast Cancer Patients

Anwar, Sumadi Lukman; Avanti, Widya Surya; Dwianingsih, Ery Kus; Cahyono, Roby; Suwardjo, Suwardjo

doi:10.31557/apjcp.2022.23.12.4109

Cited by 9 publications

(5 citation statements)

References 44 publications

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“…The frequency of molecular subtypes in our study followed the same order as those of Mighri et al [ 22 ], Al Tamimi et al [ 26 ], and Caldarella et al [ 27 ]. However, these results are inconsistent with some previous studies conducted in Algeria, Egypt, Japan, and the USA [ 28 – 31 ]. These controversies may be due to different cut-off values set for Ki-67 in the stratification of luminal BCs.…”

Section: Discussioncontrasting

confidence: 99%

“…Bone metastasis was reported as the most common site, followed by metastasis to the skin, liver, lung, and brain. A recent study was performed by Anwar et al on 1,329 females with BC to investigate risk factors, patterns, and distribution of bone metastases and skeletal-related events in high-risk BC patients [ 31 ]. Their findings showed a rate of about 18.5 percent for metastatic BC (higher than ours), but like our results, bones were the most common site of metastasis in their analysis.…”

Section: Discussionmentioning

confidence: 99%

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Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study

Pourriahi,

Omranipour,

Alipour

et al. 2023

BMC Women's Health

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Background Breast cancer (BC) is the most commonly diagnosed cancer and the leading cause of cancer death among women. Knowledge of the clinical characteristics of BC in a population may be informative for disease prediction or diagnosis and for developing screening and diagnostic guidelines. This study aimed to evaluate the clinical characteristics of female patients with BC who were admitted to academic surgical wards in Tehran, Iran. Methods In this cross-sectional study, demographic information and clinical characteristics of Iranian females with BC who had undergone breast surgery from 2017–2021 in four academic Breast Surgery Units were extracted from medical files and recorded via a pre-designed checklist. Results A total of 1476 patients with a mean age of 48.03 (± 11.46) years were enrolled. Among them, 10.4% were aged less than 35. In younger patients, Triple-negative and Her2-enriched subtypes of BC were significantly higher compared to older ones. Overall, 85.7% of tumors were invasive ductal carcinoma, 43.3% were grade 2, 41.4% were located in the UOQ, and 65.2% had presented with mass palpation. The mean pathologic tumor size was 28.94 mm, and the most common subtype was luminal B. Conclusions Many characteristics of breast cancer in this study were similar to other countries and previous studies in Iran. However, a higher proportion of young BC compared with Western countries, and even with older studies in Iran, suggest a trend toward lower age for BC in recent years. These results indicate the need for preventive measures and screening in Iranian women at a younger age.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study

Pourriahi,

Omranipour,

Alipour

et al. 2023

BMC Women's Health

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“…Advanced OSCC patients often need multimodality treatment with more severe impairments in their functioning and quality of life [ 2 ]⁠. In addition, developing countries including Indonesia also experience a shortage of facilities and manpower in cancer treatment and prevention which can add to the health burden [ 26 ] [ 27 ]⁠. Most clinical failures in the OSCC are caused by loco-regional recurrence [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

High P16INK4A Expression, Keratinizing Features, and Surgical Margin-Free Status are Associated with Improved Survival in Patients with Oral Squamous Cell Carcinomas

Anwar,

Dwianingsih,

Lestari

et al. 2024

Asian Pac J Cancer Prev

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Background: Oral squamous cell carcinoma (OSCC) continues to prevail as a highly prevalent cancer in Southeast Asia and causes a significant health burden. Stratification of patients with high risks of recurrence and mortality is important in the planning of treatment and surveillance. Methods: Formalin-fixed paraffin-embedded (FFPE) tissues of OSCC were immuno-stained and analyzed for p16 expression. Risk factors and clinical parameters of OSCC patients were collected and compared to identify factors associated with recurrences and overall survival. Results: After a median follow-up of 32 months, OSCC recurrences and mortality were observed in 82% and 78% of patients (N=60), respectively. Larger and more extensive tumors (T3 and T4) were significantly associated with both recurrences and cancer-associated mortality (OR = 3.967, 95% CI = 1.007-15.618 and OR = 5.885, 95% CI = 1.541-22.47, respectively). P16INK4A positive staining was found in 31% of tumors. Patients with p16INK4A positive staining were significantly associated with better recurrence-free and overall survivals (medians of recurrence-free survivals were 31.2 vs 19.0 months, P=0.038 and overall survivals were 39.0 vs 28.8 months, P=0.048; respectively). Some other clinical characteristics including early stages, non-keratinizing tumors, negative cervical node, and free-surgical margin were significantly associated with better recurrence-free and overall survivals (log-rank tests, P<0.05). Conclusion: P16INK4A positive staining, early stages, negative cervical lymph node infiltration, and free-surgical margins are associated with better prognosis in OSCC patients. The study emphasizes the importance of early detection and the potential use of p16INK4A and other clinical variables to stratify OSCC patients with high risks of recurrence and worse overall survivals.

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“…More than two million women are diagnosed with breast cancer and above 600.000 women lose their lives per year in association with the disease [ 1 ]⁠. Recent advances in breast cancer treatment using multidisciplinary approach have significantly improved pa-tient prognosis [ 2 , 3 ]⁠. Several clinical and pathological parameters have been used to deter-mine breast cancer prognosis including stage at diagnosis, histological grades, intrinsic sub-types, and prerequisite metabolic comorbidities [ 4 , 5 ]⁠.…”

Section: Introductionmentioning

confidence: 99%

Long-Noncoding-RNA HOTAIR Upregulation is Associated with Poor Breast Cancer Outcome: A Systematic Review and Meta Analysis

Suwardjo,

Gilang Permana,

Aryandono

et al. 2024

Asian Pac J Cancer Prev

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Background: Breast cancer is the most frequent cancer among women worldwide with significant disproportionate mortality rates in developing countries. Although clinical management of breast cancer has been immensely improved, refinement in the prognostic and recurrent markers is still needed. Long non-coding RNAs (lncRNA) HOTAIR has recently been associated with poor outcome and is potentially used as a prognostic marker in breast cancer. Methods: We comprehensively reviewed studies evaluating lncRNA HOTAIR in association with overall and disease-free survivals in breast cancers. Systematic searches were performed in Pubmed, ProQuest, ScienceDirect, Scopus, Google Scholar, Semantic Scholar, Springer, Nature, Sage Journals, and Wiley databases using combination keywords “long non-coding RNA,” “ lncRNA ,” “ HOX transcript antisense RNA ,” “ HOTAIR ,” “ breast can-cer ,” “ carcinoma mammae ,” “ prognosis ,” and “survival.” Risk of bias score was used to assess quality of studies, I 2 test was conducted to assess heterogeneity. Meta-analysis was performed to compare HOTAIR expression with breast cancer survival rates using STATA v.17 software. Results: Of the total 1,504 screened studies, seven studies were included in the meta-analysis involving 533 patients. High expression of HOTAIR was associated with poor survival rates (pooled HR: 1.69; 95%CI: 1.11-2.59; p=0.015), shorter overall survival (OS) (pooled HR: 1.33; 95%CI: 0.78-2.26; p=0.455), poor disease-free survival (DFS) (pooled HR: 2.40; 95%CI: 1.63-3.53; p<0.001), poor distant metastatic-free survival (MFS) (HR: 1.75; 95%CI: 1.13-2.71; p=0.012). In addition, overexpression of HOTAIR was associated with positive lymph node infiltration (pooled OR: 2.38; 95%CI: 0.53-10.69; p=0.26) and ductal type cancer (pooled OR: 3.27; 95%CI: 1.15-9.30; p=0.03). Conclusion: Upregulation of lncRNA HOTAIR is associated with worse DFS aand MFS that can potentially be used as a prognostic marker in breast cancer patients.

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Risk Factors, Patterns, and Distribution of Bone Metastases and Skeletal-Related Events in High-Risk Breast Cancer Patients

Cited by 9 publications

References 44 publications

Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study

Clinical characteristics of breast cancer patients admitted to academic surgical wards in Tehran, Iran: an analytical cross-sectional study

High P16INK4A Expression, Keratinizing Features, and Surgical Margin-Free Status are Associated with Improved Survival in Patients with Oral Squamous Cell Carcinomas

Long-Noncoding-RNA HOTAIR Upregulation is Associated with Poor Breast Cancer Outcome: A Systematic Review and Meta Analysis

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