Risk Factors on Health-Related Quality of Life in Children With Epilepsy

Liu, Xinjie; Han, Qizheng

doi:10.1177/0009922815580405

Cited by 21 publications

(11 citation statements)

References 31 publications

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“…The reason had been that our society places more value on male children and so are given better healthcare for their survival and maintenance of family lineage. The observation that children with seizure disorder had significantly lower total mean scores than controls was also reported by other studies [24,25,26]. Miller et al reported that the health-related quality of life in children with seizure disorder compared with the controls is diminished in all functioning domains [24].…”

Section: Discussionsupporting

confidence: 60%

Health-related quality of life of children with seizure disorder in Uyo, Nigeria

Akpan

Okpokowuruk

2018

Int J Pediatr Res

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Background: Seizure disorder is a common chronic neurologic condition in children. Children with seizure disorder have been reported to have a more compromised health-related quality of life compared with healthy children. No known study has been undertaken in our environment. Objectives: To assess the health-related quality of life of children with epilepsy and to compare it with that of apparently healthy children in Uyo, Nigeria. Methods: Child self-report and parent-proxy report questionnaires (Pediatrics Quality of Life inventory version 4.0) were administered to 60 children and their mothers. Thirty of the children had seizure disorders and 30 were apparently healthy children who were age, gender and social class matched with the subjects. Parental education and occupation were used to allot a social class to the children. Results: Of the 30 subjects/controls, 10 (33.3%) were males while 20 (66.7%) were females giving a male to female ratio of 1:2. Thirteen belonged to 8-12 years age group, 12 were 13-18 years old while 5 were 5-7 years of age. Majority (27) belonged to the upper and middle social classes and 3 belonged to the lower social class. Twenty children had good seizure control while 10 had one or more seizure episodes per month. Children with seizure disorder had mean total score and mean score in the subscales that was significantly lower than that of the controls. Good quality of life was associated with good seizure control. Conclusion: Children with seizure disorder had lower health related quality of life than apparently healthy children. There is therefore need to maintain good seizure control in children with seizure disorder as it has a positive impact on health-related quality of life of these children.

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Section: Discussionsupporting

confidence: 60%

Health-related quality of life of children with seizure disorder in Uyo, Nigeria

Akpan

Okpokowuruk

2018

Int J Pediatr Res

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“…While some studies revealed relatively good QOL measures in both children and parents (Ferro et al, 2017), a systematic review revealed that parents of children with epilepsy had a reduced quality of life, similar to parents of children with other chronic conditions; mothers were more affected than fathers (Puka et al, 2018). QOL was inversely associated with socioeconomical status, anxiety and depression, but seemed not to be correlated with the child's seizure frequency (Ferro et al, 2017;Puka et al, 2018), although a recent study found that children with higher seizure frequency and younger age at onset presented with lower QOL scores (Liu et al, 2015). The main reported determinants of both felt stigma and QOL are summarized in table 2.…”

Section: Cultural Aspects and Consequences Of Diagnosismentioning

confidence: 99%

How to understand and address the cultural aspects and consequences of diagnosis of epilepsy, including stigma

Braga¹,

Hosny²,

Kakooza‐Mwesige³

et al. 2020

Epileptic Disorders

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Epilepsy is one of the most prevalent serious neurological diseases. It is unique, being the only severe and disabling neurological disease that is fully treatable in the majority of cases, but on the other hand, associated with stigma, prejudice and discriminatory practices, which negatively impact people's everyday life in important areas, such as access to education, employment, marriage and social integration. For centuries, people with epilepsy (PWE) were stigmatized in all societies, with the consequences of prejudice and discrimination adding to the medical burden of the disease. Myths and misconceptions about this disease still occur, mostly in low-resources settings, however, in many industrialized countries, the knowledge regarding epilepsy is still limited in the population. The stigma is perceived as a negative attribute that is undesirable for the community to which the individual belongs. PWE are intrinsically undervalued, both by themselves ("felt stigma") and by the others. Actual discrimination by peers and institutions generates what is referred to as "enacted stigma". Misconceptions, stigma and negative attitudes towards PWE dramatically decrease quality of life, affecting the most sensitive areas, such as marriage, employment and driving. The Resolution 68.28 of the World Health Assembly (2015), the WHO-ILAE-IBE Global Report "Epilepsy: a public health imperative", advocates for strengthening and implementing national policies and legislation to promote and protect the rights of PWE, reducing misconceptions about epilepsy and improving access to care. Consolidated efforts are required from different organizations, public health managers, healthcare providers, PWE and their families to work together to improve socialization and quality of life of PWE. Educational programs and awareness to support activities among the general population, health service providers and PWE are the best way to reduce all types of stigma and discrimination.

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“…These three clinical factors suggested that specific features can identify children at high risk of poor healthrelated QOL. 20 No statistical significance was found in difference of QOL in children with focal epilepsy and the presence of epileptic syndrome. This may be a sign that children and parents are not much concerned about the severity or type of epilepsy, but taking more drugs or having frequent seizures has a more negative impact on QOL.…”

Section: Discussionmentioning

confidence: 95%

Quality of Life in Children with Epilepsy

Prajapati

Dwivedi

Bajaj

2020

Journal of Pediatric Epilepsy

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Abstract Objective The main aim of this study was to assess quality of life in children with epilepsy. Materials and Methods A prospective observational study was conducted in Regional Early Intervention Centre of the Department of Pediatrics Tertiary Care Hospital in central India. This study included 120 children with epilepsy aged between 2 and 18 years. In this study, we assessed the quality of life in children with epilepsy with the help of Pediatric Quality of Life Inventory (PedsQL). We further analyzed the quality of life in various dimensions. For the statistical analyses for SPSS version, 20 was used, chi-squared and Fisher's exact test was used for categorical variables, and Student's t-test was used for quantitative variables. Linear regression analysis was done for multivariate analysis. Result Mean total PedsQL score for total cohort was 70.96. The cognitive dimension of epileptic children was more affected than physical, social, and emotional dimensions. Factors associated with lower PedsQL scores in epilepsy patients were associated with long duration of epilepsy, polytherapy, male gender, low head circumference, presence of intellectual disability, and refractory epilepsy. Conclusion Epilepsy affects the quality of life in children across all age groups. Among epilepsy indicators, polytherapy, refractory epilepsy, and duration of epilepsy were the most important factors associated with poor quality of life. We can conclude that every effort should be made to decrease the duration of treatment and minimize the number of drugs for improving the quality of life in this patient cohort.

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Risk Factors on Health-Related Quality of Life in Children With Epilepsy

Cited by 21 publications

References 31 publications

Health-related quality of life of children with seizure disorder in Uyo, Nigeria

Health-related quality of life of children with seizure disorder in Uyo, Nigeria

How to understand and address the cultural aspects and consequences of diagnosis of epilepsy, including stigma

Quality of Life in Children with Epilepsy

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