Risk Factors of Urinary Pathogenic Bacteria Infection after Benign Prostatic Hyperplasia Surgery and Curative Effect Analysis of Shuangdong Capsule Intervention

Abstract

Benign prostatic hyperplasia (BPH) is a common and frequently occurring disease in clinics, with the main manifestations including frequent micturition, urinary incontinence, dysuria, and endless urination. Transurethral resection of the prostate (TURP) is the main treatment for BPH, but some patients are prone to urinary tract infection after surgery, which affects the prognosis. Therefore, it is of great significance to study the pathogenic characteristics and risk factors of postoperative urinary-derived pathogenic bacteria infection in patients with BPH for the prevention and treatment of postoperative infection. In addition, the treatment of patients with this disease is also the focus of clinical attention. Long-term massive application of antibiotics can induce drug-resistant mutations of bacteria, so it is urgent to find an efficient and safe therapeutic scheme in clinics. However, traditional Chinese medicine (TCM) has a long history of treating urinary tract infections. Therefore, Shuangdong capsule, a traditional Chinese medicine preparation, was selected for the combined treatment in this study. The results showed that age, concomitant diabetes mellitus, and preoperative prophylactic application of antibiotics were the independent risk factors for postoperative urine-derived pathogenic infection in BPH patients. Clinical intervention for BPH patients with concomitant risk factors should be emphasized in clinical practice. The combined use of Shuangdong capsule and conventional western medicine can improve the clinical symptoms and inflammatory reactions of postoperative urine-derived pathogenic infection in BPH patients. Due to its exact curative effect and high safety, it is worthy of promotion. The clinical study registration number is M2022019.

Analysis of risk factors for benign prostate enlargement with prostate calcification

“…UA and BUN have been linked to kidney diseases and conditions like hyperuricemia. Additionally, dietary habits, particularly excessive consumption of proteinbased foods, could contribute to a simple increase in urea nitrogen levels [29,30]. PSA is an enzyme present in human prostatic acinar and ductal epithelial cells and is synthesized in normal, cancerous and metastatic cancer cells.…”

It is not the best option to perform transurethral enucleation of the prostate immediately after biopsy in patients with histological inflammation

“…In the findings of this study, patients with PI exhibited elevated postoperative infection markers compared to patients without PI, such as increased levels of postoperative white blood cells and C-reactive protein, as well as a higher incidence of postoperative fever. Xu et al ( 14 ) conducted an analysis on the risk factors for urinary tract infections after prostatic hyperplasia surgery, revealing that BPH patients with prostatitis faced a significantly heightened risk of postoperative infection and fever, both of which could be effectively mitigated through the administration of antibiotics. This phenomenon may be attributed to the destruction of prostate tissue during surgical procedures and the subsequent rise in pressure due to intraoperative perfusion, leading to the infiltration of inflammatory mediators into the bloodstream ( 15 ).…”

Retracted: Risk Factors of Urinary Pathogenic Bacteria Infection after Benign Prostatic Hyperplasia Surgery and Curative Effect Analysis of Shuangdong Capsule Intervention

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…Tis article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. Tis investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”