Risk factors of sexual dysfunction after transurethral resection of the prostate (TURP): A12 months follow-up

Favilla, Vincenzo; Cimino, Silvia; Salamone, Costanza; Fragalà, Eugenia; Madonia, Massimo; Condorelli, Rosita A.; Vignera, Sandro La; Mongioì, Laura M.; Farina, Furio Pirozzi; Russo, Giorgio Ivan; Morgia, Giuseppe

doi:10.1007/bf03346761

Cited by 28 publications

(12 citation statements)

References 29 publications

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“…Besides these major premises, several community-based studies have recently confirmed the association between LUTS and ED [6][7][8]. Although severity of LUTS, assessed by the International Prostate Symptom Score (IPSS), significantly correlates with the prevalence of ED, the exact relationship between these two agedependent conditions remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Insulin Resistance Is an Independent Predictor of Severe Lower Urinary Tract Symptoms and of Erectile Dysfunction: Results from a Cross-Sectional Study

Russo

Cimino

Fragalà

et al. 2014

The Journal of Sexual Medicine

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Introduction Several studies have linked the association between lower urinary tract symptoms (LUTS), erectile dysfunction (ED), and the presence of insulin resistance (IR) due to an underlined metabolic syndrome (MetS). Aim This study aims to determine the relationship between IR, sexual function, and LUTS and to demonstrate the ability of IR in predicting ED and severe LUTS. Methods Between January 2008 to January 2013, 544 consecutive patients with benign prostatic hyperplasia-related LUTS were enrolled. LUTS and sexual function of the patients were evaluated by the International Index of Erectile Function (IIEF) and the International Prostate Symptom Score (IPSS). MetS was defined by the International Diabetes Federation. IR was defined as a homeostasis model assessment (HOMA) index of 3 or greater. Main Outcome Measures Uni- and multivariate logistic regression analysis was performed to assess significant predictors of severe LUTS (IPSS ≥20) and ED (IIEF-Erectile Function [IIEF-EF] <26), including MetS component, prostate volume, prostate-specific antigen, total testosterone, and HOMA index. Results IR patients resulted in higher values of IPSS (19.0 vs. 15.0; P < 0.01), IPSS-storage (6.0 vs. 5.0; P < 0.01), IPSS-voiding (12.0 vs. 9.0; P < 0.01), total prostate volume (54.8 vs. 36.5; P < 0.01), and lower values of IIEF-EF (17.0 vs. 20.0; P < 0.01), IIEF-Intercourse Satisfaction (3.0 vs. 10.0; P < 0.01), IIEF-Orgasmic Function (8.0 vs. 9.0; P < 0.01), IIEF-Overall Satisfaction (6.0 vs. 8.0; P < 0.01), and total testosterone (3.83 vs. 4.44; P < 0.01). IR was demonstrated to be a strong predictor of ED (IIEF-EF <26) (odds ratio [OR] = 6.20, P < 0.01) after adjusting for confounding factors. Finally, IR was also an independent predictor of severe LUTS (IPSS ≥20) (OR = 2.0, P < 0.01) after adjusting for confounding factors. Conclusions IR patients are at high risk of having severe LUTS and contemporary sexual dysfunctions. We strongly suggest to prevent LUTS and ED by reducing insulin resistance.

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Section: Introductionmentioning

confidence: 99%

Insulin Resistance Is an Independent Predictor of Severe Lower Urinary Tract Symptoms and of Erectile Dysfunction: Results from a Cross-Sectional Study

Russo

Cimino

Fragalà

et al. 2014

The Journal of Sexual Medicine

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“…22 The important role of organic determinants and, in particular, CVD risk factors have been considered the most important pathogenic factors underlying ED 1 and our findings may be justified by previous observations where men with CVD and overall atherosclerotic cardiovascular events frequently experienced ED. [24][25][26][27] One of the major strengths of this study was to create a multivariable risk group stratification that could be helpful in daily practice.…”

Section: Discussionmentioning

confidence: 99%

Predicting erectile dysfunction in sexually active patients seeking prostate health screening: proposal for a multivariable risk stratification

et al. 2015

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To address the severity of erectile dysfunction (ED) in consecutive sexually active men seeking a prostate health screening through a multivariable risk stratification including comorbidities and lower urinary tract symptoms (LUTS). Four hundred and twenty five consecutive subjects with stable sexual relationship with normal testosterone levels were enrolled. The International Index of Erectile Function (IIEF-5) and the International Prostate Symptom Score (IPSS) questionnaires were collected and health-significant comorbidities were scored with the Charlson comorbidity index (CCI). All the independent predictors of ED were combined to form four different risk categories of ED: low (age⩽65 years and IPSS<8 and CCI=0), intermediate (one of the following: age>65 years, IPSS⩾8 or CCI⩾1), high (two of the following: age>65 years, IPSS⩾8 or CCI⩾1) and very high (age >65 years, IPSS⩾8 and CCI⩾1). The prevalence of ED increased with increase of CCI (χ(2) likelihood ratio: 40.85, P=0.001). The median of the IIEF-5 significantly reduced with the increase of the CCI (P<0.001) and with the worsening of our risk group stratification (P<0.001). At univariate logistic regression analysis very high risk was significantly associated with of ED (odds ratio: 26.85, P<0.001). Very high-risk group predicted ED with 88% and 56% of specificity and sensitivity, respectively. Combining these risk factors through our risk stratification may be usefulness in revealing an underling ED.

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“…Besides age, LUTS and MetS also participate in a variety of other risk factors, such as obesity, hyperglycemia, hypertension, lack of androgen, depression, and smoking, consequently indicating that metabolic syndrome might have a major role in the pathogenesis of LUTS [11] A link between metabolic syndrome and prostate growth rate has also been found in clinical series [12,13] . All these findings point out that the MetSrelated BPH/ LUTS should be counted as potentially objective therapy in order to oppose the resulting prostate rapid growth [14] The objective of the present study was to evaluate the effects of MetS on the prostatic volume and LUTS/BPH in a sample of Iraqi men aged >50 years.…”

Section: Introductionmentioning

confidence: 96%

Impact of components of metabolic syndrome on the prostatic volume and lower urinary tract symptoms in a sample of patient with benign prostatic hyperplasia in Iraq

Al-Dabbagh¹,

Khudhur²

2019

GJUN

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Research Article GJUN (2019) 2:17 Impact of components of metabolic syndrome on the prostatic volume and lower urinary tract symptoms in a sample of patient with benign prostatic hyperplasia in Iraq Objective To evaluate the association between the components of metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) due to benign prostatic hyperplasia (BPH) focusing at their effects on prostatic volume and on the severity of LUTS. Patients & Methods From October 2016 to January 2018, eighty patients presented with LUTS due to the BPH. LUTS were assessed using the international prostatic symptoms score (IPSS) and MetS was defined according to the National Cholesterol Education Program-Adult Treatment Panel III guidelines. Patients were randomly collected into two categories: A (48 patients) had MetS and B (32 patients) without MetS. Results The mean age was 64.3 years, statistically significant variation was identified between the two categories regarding the moderate and severe IPSS, S.PSA, prostatic size and post voiding residue (PVR), the P value (<0.05). The most frequent MetS components were: hypertension in 65/80 patients (81.25%), high fasting glucose in 49/80 patients (61, 25%), and waist circumference elevation in 55/80 patients (68.75%). The association between MetS components, the prostatic volume and severity of LUTS had shown that all MetS components except HDL-cholesterol were significantly correlated with higher prostatic volume (P < 0.05). Also a positive statistically significant association was discovered between each component of MetS and higher IPSS, excepting HDL-cholesterol (P = 0.93) and triglyceride (P = 0.58). Conclusion The results of the present study confirmed that there is a significant relation between the components of metabolic syndrome, the increase in prostatic volume and the severity of LUTS/BPH.

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Risk factors of sexual dysfunction after transurethral resection of the prostate (TURP): A12 months follow-up

Cited by 28 publications

References 29 publications

Insulin Resistance Is an Independent Predictor of Severe Lower Urinary Tract Symptoms and of Erectile Dysfunction: Results from a Cross-Sectional Study

Insulin Resistance Is an Independent Predictor of Severe Lower Urinary Tract Symptoms and of Erectile Dysfunction: Results from a Cross-Sectional Study

Predicting erectile dysfunction in sexually active patients seeking prostate health screening: proposal for a multivariable risk stratification

Impact of components of metabolic syndrome on the prostatic volume and lower urinary tract symptoms in a sample of patient with benign prostatic hyperplasia in Iraq

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