Risk factors of renal replacement therapy after heart transplantation: a retrospective single-center study

Abstract

Background: Acute kidney injury (AKI) and renal replacement therapy (RRT) are common after heart transplantation (HT). The need for RRT has been reported to be one of the most important predictors of a poor prognosis after HT. Therefore, it is important to early identify risk factors of RRT after HT. However, in the heart transplantation setting, the risk factors are less well studied, and some of the conclusions are controversial. This study aimed to identify the clinical predictors of RRT after HT.Methods: This single-center, retrospective study from January 2010 to June 2021 analyzed risk factors (pre-, intra-, and postoperative characteristics) of 163 patients who underwent HT. The endpoint of the study was RRT within 7 days of HT. Risk factors were analyzed by multivariable logistic regression models.Results: Fifty-five (33.74%) recipients required RRT within 7 days of HT. Factors independently associated with RRT after HT were as follows: a baseline estimated glomerular filtration rate (eGFR) <60 mL/min per 1.73 m 2 [odds ratio (

Mortality and morbidity after combined heart and liver transplantation in the failing Fontan: An updated dual center retrospective study

“…This cardio‐renal syndrome may intersect with a hepato‐renal syndrome from FALD. As above, a primary risk factor for need for RRT post heart transplantation is increased CPB time 34 . In addition to decreasing CPB times, further study is warranted to assess if pre‐operative optimization with inotropes or mechanical support, as well as renal protective medications such as aminophylline can improve renal function pre‐transplant and attenuate risk for RRT.…”