Risk factors of renal involvement and significant proteinuria in Henoch-Schönlein purpura

Sano, Hitomi; Izumida, Michiko; Shimizu, Hiroshi; Ogawa, Yutaka

doi:10.1007/s00431-002-0922-z

Cited by 138 publications

(127 citation statements)

References 23 publications

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“…2,8,10,11 In our sample, we observed microscopic hematuria in 12.7% of our patients, with a greater percentage among recurrent cases (41.6%).…”

Section: Discussionsupporting

confidence: 47%

Púrpura de Henoch-Schönlein: recorrência e cronicidade

Alfredo¹,

Nunes²,

Len³

et al. 2007

J. Pediatr. (Rio J.)

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Objectives: To describe a group of patients treated at our service for Henoch-Schönlein purpura, with emphasis on recurrent and chronic cases, and to compare clinical and demographic characteristics of patients with monocyclic and recurrent disease. Methods:Data on 67 patients who had been treated since disease onset were analyzed. Twelve patients were excluded because they failed to return for follow-up consultations after less than 3 months, leaving a total of 55 children in the study sample. Recurrence was defined as the presence of a fresh episode after a period of at least 3 months without symptoms, and cases were defined as chronic when cutaneous, abdominal and renal manifestations persisted for a period of 12 months or more.Results: Recurrence was observed in 8/55 patients (14.4%) and four cases were chronic (7.2%). In 29/55 patients (52.7%), infection was identified as the trigger factor. A monocyclic clinical course was observed in 43 patients (26 of whom were girls, with a mean age of 5.4 years). Gastrointestinal and renal involvement was observed in 55.8 and 20.9% of patients, respectively. Among the 12 patients with recurrent or chronic Henoch-Schönlein purpura, three had arthritis, four exhibited signs and symptoms of abdominal involvement and seven of kidney disease: microscopic hematuria in five, macroscopic hematuria in one and hematuria with proteinuria in one other.Late onset was the only variable related to recurrence (p < 0.05). Conclusions:As is observed in medical literature, monocyclic cases are more common among children with early onset disease. Patients with Henoch-Schönlein purpura should be followed over the long term, since recurrent and chronic cases account for more than 20% of the total.

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“…2,8,10,11 In our sample, we observed microscopic hematuria in 12.7% of our patients, with a greater percentage among recurrent cases (41.6%).…”

Section: Discussionsupporting

confidence: 47%

Púrpura de Henoch-Schönlein: recorrência e cronicidade

Alfredo¹,

Nunes²,

Len³

et al. 2007

J. Pediatr. (Rio J.)

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“…The independent risk factors for Henoch-Schönlein purpura nephritis were persistent purpura, severe abdominal symptoms and age above 4 or 7 or 10 years. Other independent risk factors were relapse or decreased serum factor XIII activity (Kaku et al, 1998;Sano et al, 2002;Rigante et al, 2005;. Persistent purpura, severe abdominal symptoms and an older age were confirmed as the most significant risk factors for later nephropathy (Bogdanovic, 2009).…”

Section: Renal Involvement In Henoch-schönlein Purpuramentioning

confidence: 88%

“…Persistent rash was a poor prognostic factor for HenochSchönlein purpura nephritis (Hung et al, 2009). Renal signs are manifested in the majority of Henoch-Schönlein purpura patients from 3 days to 17 months after onset of the disease (Kaku et al, 1998), occurring more frequently within the first 3 months (Sano et al, 2002). In few cases the renal disease may develop even years after the initial presentation (Mollica et al, 1992).…”

Section: Clinical Patternsmentioning

confidence: 98%

Henoch-Schönlein Purpura Nephritis in Childhood

Zaffanello¹

2011

An Update on Glomerulopathies - Clinical and Treatment Aspects

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“…It is much more common in children than in adults. It is reported that it generally occurs between the ages of 5-15, on average around 5-6 years of age [4,[16][17][18][19]. As palpable purpuric rash of different sizes from small petechiae to large ecchymoses which are more dominant on the lower extremities is characteristic in HSP, it is generally diagnostic.…”

Section: Discussionmentioning

confidence: 99%

Tooth fragments embedded in the lower lip following trauma

Benzer¹,

Duramaz²,

Önal³

et al. 2015

MMJ

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Objectives: Henoch-Schönlein purpura (HSP) or IgA vasculitis, is the most common form of childhood vasculitis. Mean platelet volume (MPV) is a parameter of a complete blood count that shows thrombocyte function and activation. This study evaluated the link between MPV and HSP. Patients and Methods:The data of 75 patients with a diagnosis of HSP were retrospectively evaluated. A control group was formed with 79 healthy children of similar gender and ages. results:The average ages were 6.8±3.02 years (44 males, 31 females) and 7.49±2.95 years (40 males, 39 females) for the patient and control groups respectively. Mean platelet volume was found to be significantly lower in the study group (p<0.0001). Patients' thrombocyte count were significantly higher (p<0.0001). Upon presentation 18 patients' faecal occult blood (FOB) test results were positive, and there was microscopic hematuria in 12 patients, MPV was found to be significantly lower in FOB positive patients (p=0.043).conclusion: Inflammation may affect MPV levels by increasing or decreasing. In our study, MPV measurements performed by a cheap and simple method, have been considered as a negative acute phase reactant. Decreased MPV measurements despite increased platelet count may be important in the prediction of hypercoagulopathy problems during the likely course of the disease and in close follow up for those with a predisposition. Ortalama trombosit hacmi çalışma grubunda anlamlı derecede düşük saptandı (p<0,0001). Hastaların trombosit sayısı anlamlı derecede yüksek bulundu (p<0,0001). Başvuru anında 18 hastada gizli gaite kan (GGK) testi pozitifti ve 12 hastada mikroskopik hematüri mevcuttu, GGK pozitif olan hastalarda OTH anlamlı düşük bulundu (p=0,043). sonuç: İnflamasyon, OTH düzeyini artma/azalma şeklinde etkileyebilmektedir. Çalışmamızda ucuz ve basit bir yöntem olan OTH ölçümleri negatif akut faz reaktanı olarak değerlendirilmiştir. Henoch-Schönlein purpuralı çocuklarda, artmış trombosit sayısına karşın, azalmış OTH ölçümlerinin, yatkınlığı olanlarda, hastalık seyrindeki olası hiperkoagülopati problemlerinin önceden belirlenmesinde ve yakın takipte önemli olabileceği kanısına varılmıştır.

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Risk factors of renal involvement and significant proteinuria in Henoch-Schönlein purpura

Cited by 138 publications

References 23 publications

Púrpura de Henoch-Schönlein: recorrência e cronicidade

Púrpura de Henoch-Schönlein: recorrência e cronicidade

Henoch-Schönlein Purpura Nephritis in Childhood

Tooth fragments embedded in the lower lip following trauma

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