Risk factors of recurrent pancreatitis after first acute pancreatitis attack: a retrospective cohort study

Cho, Joon Hyun; Jeong, Yo Han; Kim, Kook Hyun; Kim, Tae Nyeun

doi:10.1080/00365521.2019.1699598

Cited by 21 publications

(14 citation statements)

References 29 publications

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“…Dynamic changes in body composition may be the direction of future research. In addition, many studies have shown that alcoholism, cigarette smoking, hypertriglyceridemia, and local complications are risk factors for recurrent pancreatitis [39,40]. Our study showed no signi cant association between hypertriglyceridemia and recurrence of HTGP.…”

Section: Discussioncontrasting

confidence: 61%

Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Huang

Chen

et al. 2021

Preprint

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Background: Analytic morphometric assessment has recently been proposed to be applied to the study of acute pancreatitis (AP). However, the relationship between body composition and the outcomes of hypertriglyceridemic pancreatitis (HTGP) is still unclear. The aim of this study was to evaluate body composition in relation to the length of hospital stay (LOS) and recurrence of HTGP.Methods: Patient characteristics, admission examination data, body composition parameters, LOS, and recurrence within 1 year were collected from the institutional pancreatitis database and follow-up records. Logistic regression analysis was used to identify risk factors for LOS and recurrence of HTGP.Results: Of the 196 included patients, 158 (80.6%) were men and 53 (27.0%) were sarcopenic. The average LOS was 15.83±10.02 days. The recurrence rate of HTGP was 36.7%. Multivariate analysis with multiple linear regression suggested that subcutaneous fat area (SFA) (p=0.019) and high-density lipoprotein-cholesterol (HDL-C) (p=0.001) were independently associated with the LOS for HTGP after adjusting for age and sex. The multivariate adjusted hazard ratios for SFA and HDL-C, with respect to the relationship between body parameters and LOS, were 1.008 (95% confidence interval [CI], 1.001–1.015) and 0.090 (95% CI, 0.022–0.361), respectively. No significant differences were observed between the AP and recurrent AP (RAP) groups in terms of characteristics, admission examination data, and body composition parameters.Conclusion: SFA and HDL-C are associated with LOS in patients with HTGP. The body composition of patients at the first symptom onset of HTGP cannot predict recurrence.

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Section: Discussioncontrasting

confidence: 61%

Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Huang

Chen

et al. 2021

Preprint

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“…In a study conducted in Korea, with a median follow-up of 3.2 years in RAP, age <60 years (HR = 1.602, 95%CI: 1.029–2.493) and male gender (HR = 1.927, 95%CI: 1.127–3.295) were significant risk factors for RAP development. [ 18 ]…”

Section: Discussionmentioning

confidence: 99%

Different clinical characteristics between recurrent and non-recurrent acute pancreatitis: A retrospective cohort study from a tertiary hospital

Ding¹,

Song²,

Guo³

et al. 2022

Saudi J Gastroenterol

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Background: Acute pancreatitis (AP) is a common digestive disorder with different clinical outcomes, some of which develop into recurrent acute pancreatitis (RAP). This study aimed to explore the differences between AP and RAP. Methods: All patients with AP admitted to Changsha Central Hospital between January 2015 and December 2020 were included. Characteristics between RAP and non-RAP groups were compared. Independent factors associated with RAP were identified by multivariate logistic regression analyses. Results: This was a retrospective study. A total of 1567 patients, including 262 patients in the RAP group and 1305 patients in the non-RAP group, were enrolled. Compared to the non-RAP group, results indicated that the RAP group was younger ( P < 0.001), had a male predominance ( P < 0.001), and had higher incidences of diabetes ( P < 0.001) and hypertriglyceridemia (HTG) ( P < 0.001). Lower incidences of cholelithiasis ( P < 0.001) and acute liver injury ( P < 0.001) were also noted in the RAP group. Scores of Ranson, BISAP, SOFA, and APACHE II were significantly higher in the non-RAP group ( P < 0.001 for all). Three independent factors associated with RAP, including male gender ( P = 0.006), diabetes ( P < 0.001), and HTG ( P < 0.001), were identified by multivariate logistic regression. Conclusion: Compared to the non-RAP, the incidence of cholelithiasis and acute liver injury was lower in RAP. Three independent factors associated with RAP, namely male, diabetes, and HTG, were identified.

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“…22,41 Cho et al found that a local complication at index admission in patients with first episode pancreatitis was the strongest risk factor for RAP. 42 The occurrence of local complications may be related to structural changes in the pancreas after recovery from pancreatitis. Our regression analysis found that patients who developed infected pancreatic necrosis during their first hospitalization had a fivefold higher risk of recurrence than those who without.…”

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confidence: 99%

Risk Factors for Recurrent Pancreatitis After First Episode of Acute Pancreatitis

Sun¹,

Jin²,

Zhu³

et al. 2022

IJGM

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In recent years, the cure rate of acute pancreatitis (AP) has increased gradually, but the morbidity of recurrent acute pancreatitis (RAP) has not decreased. Patients with RAP have a poor quality of life and are more likely to develop into chronic pancreatitis. To investigate the risk factors of RAP after first pancreatitis attack is very necessary. Methods: Patients with first episode AP admitted to Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine from January 2018 to May 2021 were included in this retrospective study, and follow-up was 3-45 months after discharge. The patients information were collected from medical records including laboratory tests and auxiliary inspection of their hospitalization. Univariate and multivariate Cox regression analysis were used to explore the risk factors of RAP. Cumulative risk of RAP was plotted using Kaplan-Meier curves. Results: A total of 592 patients were enrolled in the study and 81 (13.7%) of the patients developed RAP. Among those RAP patients, the majority (67.9%) were men, with a median age of 43 years. The most common etiology of RAP was hypertriglyceridemia (38.3%). Multivariate Cox analysis showed that smoking history (p < 0.001), infected pancreatic necrosis occurred during first admission (p = 0.005), and high low-density lipoprotein cholesterol (LDLc) level (p < 0.001) were significant independent risk factors for RAP. Patients with the above independent risk factors had increased 3-year cumulative risk of recurrence (32.2%, 45.5%, 28.9%, respectively). Conclusion: Smoking history, infected pancreatic necrosis, and high LDLc level were the most decisive risk factors for RAP. Attention should be paid to the patients with the above factors.

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Risk factors of recurrent pancreatitis after first acute pancreatitis attack: a retrospective cohort study

Cited by 21 publications

References 29 publications

Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Assessment of Computed Tomography-Defined Muscle and Adipose Tissue Features in Relation to Length of Hospital Stay and Recurrence of Hypertriglyceridemic Pancreatitis

Different clinical characteristics between recurrent and non-recurrent acute pancreatitis: A retrospective cohort study from a tertiary hospital

Risk Factors for Recurrent Pancreatitis After First Episode of Acute Pancreatitis

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