Risk factors of postoperative infection in head and neck surgery

Ogihara, Hitomi; Takeuchi, Kazuhiko; Majima, Yuichi

doi:10.1016/j.anl.2008.10.005

Cited by 106 publications

(106 citation statements)

References 13 publications

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“…Previous studies have identified a significant association between blood loss and frequency of surgical site infection in patients who underwent head and neck surgery (6,11,12). In the present study, no significant differences in regards to the occurrence of postoperative infectious complications between patients with low blood loss (11.1%) and those with high blood loss (15.0%) were observed, although postoperative complications showed a declining tendency in the former group.…”

Section: A B Discussioncontrasting

confidence: 57%

Professional oral health care reduces the duration of hospital stay in patients undergoing orthognathic surgery

et al. 2015

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Abstract. The present study reviewed the records of 58 patients who underwent orthognathic surgery [sagittal split ramus osteotomy (SSRO), Le Fort I osteotomy, genioplasty, anterior maxillary alveolar osteotomy] between 2010 and 2015. To investigate the influence of preoperative oral health care on postoperative inflammation, infection and length of hospital stay in those patients, white blood cell (WBC) count and C-reactive protein (CRP) levels were compared between patients who received and did not receive preoperative oral care. The mean CRP level throughout the postoperative term was lower in the oral care group as compared to the non-oral care group. By contrast, the oral care group had a lower occurrence of postoperative infectious complications (surgical site infection, anastomotic leak) (13.6 vs. 20.8%) and a shorter average length of hospital stay (16.2±3.8 vs. 21.2±7.4 days). These results suggest that preoperative professional oral health care decreases the duration of hospital stay following orthognathic surgery by inhibiting inflammation and infectious complications during the postoperative stage.

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Section: A B Discussioncontrasting

confidence: 57%

Professional oral health care reduces the duration of hospital stay in patients undergoing orthognathic surgery

et al. 2015

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“…The risk of SSI has been reported to be 10.9% to 45.0% in patients who undergo head and neck cancer surgery, despite parenteral antibiotic prophylaxis. [1][2][3][4][5][6][7][8] SSI not only causes a prolonged hospital stay and decreased quality of life in patients who undergo oral cancer surgery, but also adversely impacts the outcome because of the need to delay postoperative treatment in patients with adverse prognostic features. The CDC guidelines [13] state that the risk of SSI can be conceptualized as a level of bacterial contamination Â virulence/resistance of the host patient, and that if a surgical site is contaminated with >10 5 microorganisms per gram of tissue, the risk of SSI is markedly increased.…”

Section: Discussionmentioning

confidence: 99%

“…The sample size was calculated from a previous report and our pilot study. [1][2][3][4][5][6][7][8][9] We assumed a 30% incidence of SSI in the control group and that intervention could reduce this figure to 15%. A 2-tailed significance level of a = 0.05 and a power of 0.90 required enrollment of 132 patients.…”

Section: Methodsmentioning

confidence: 99%

“…[1][2][3][4][5][6][7][8] The reasons for the high incidence of SSI are thought to include not only surgical technique and poor preoperative nutrition but also the presence of pathogenic microorganisms in the oral cavity. Furthermore, patients with oral cancer who undergo tumor resection combined with reconstructive surgery and tracheotomy have higher than normal levels of bacteria in the oropharyngeal fluid because of swallowing disturbance and reduced selfcleaning in the oral cavity.…”

Section: Introductionmentioning

confidence: 99%

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Prevention of surgical site infection after oral cancer surgery by topical tetracycline: Results of a multicenter randomized control trial.

Funahara

Yanamoto

Suzuki

et al. 2018

JCO

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Background: In a pilot study, we showed that topical administration of a tetracycline could decrease oral bacteria levels for 6 hours in patients who underwent oral cancer surgery combined with tracheotomy and flap reconstruction. This multicenter, randomized control trial aimed to investigate the effectiveness of topical application of tetracycline ointment for prevention of surgical site infection (SSI) associated with major oral cancer surgery.Methods: One hundred seventeen patients who underwent oral cancer resection combined with neck dissection, flap reconstruction, and tracheotomy were divided randomly into an intervention group (n = 56) and a control group (n = 61). The intervention consisted of topical administration of tetracycline ointment on the dorsum of the tongue every 6 hours for 48 hours postoperatively. Factors relating to the occurrence of SSI in both groups were subjected to logistic regression analysis.Results: SSI occurred in 11 patients (19.6%) in the intervention group and 22 patients (36.1%) in the control group. Multivariate analysis showed that a longer operating time and not receiving topical tetracycline were independent risk factors for development of SSI.Conclusion: Administration of topical tetracycline for 48 hours postoperatively is an effective way of preventing SSI after oral cancer surgery.Abbreviations: CDC = Centers for Disease Control and Prevention, RCT = randomized control trial, SSI = surgical site infection.

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“…Ogihara et al 1 examined the benefits of antibiotic coverage in these surgeries. They conclude that an association of molecules targeting aerobes, anaerobes and Gramnegative bacteria has a greater action than that of a simple agent.…”

Section: Perio Disease and Flap Reconstruction Failurementioning

confidence: 99%

Restorative dentistry: Cronlays?

Maidment

2018

Br Dent J

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Risk factors of postoperative infection in head and neck surgery

Cited by 106 publications

References 13 publications

Professional oral health care reduces the duration of hospital stay in patients undergoing orthognathic surgery

Professional oral health care reduces the duration of hospital stay in patients undergoing orthognathic surgery

Prevention of surgical site infection after oral cancer surgery by topical tetracycline: Results of a multicenter randomized control trial.

Restorative dentistry: Cronlays?

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