Risk factors of post-surgery complications in children with thyroid cancer

J, Babala; Zahradníková, Petra; Béder, I; Fědorová, Lenka; Lindák, Martin; Kostalova, Ludmila; Pribilincová, Zuzana; Staník, Juraj; Kralik, Robert

doi:10.1016/j.ijporl.2019.109673

Cited by 7 publications

(20 citation statements)

References 42 publications

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“…The postoperative hypoparathyroidism was also more prevalent in children younger than 3 years at surgery in particular (11,75,77). However, there were also studies reported that age at surgery in children was not associated with these complications (70,74,78). Several strategies, including meticulous intraoperative identification to reduce local damage using optical magnification or nerve-monitoring devices, preserve parathyroid glands in situ, and transfer patients to higher-volume surgeons, may be useful in improving the outcomes (11,74,79).…”

Section: Personalized Precision Treatment Of Men2mentioning

confidence: 99%

5P Strategies for Management of Multiple Endocrine Neoplasia Type 2: A Paradigm of Precision Medicine

Ding

et al. 2020

Front. Endocrinol.

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Multiple endocrine neoplasia type 2 (MEN2) is a neuroendocrine cancer syndrome characterized by medullary thyroid carcinoma, in combination or not with pheochromocytoma, hyperparathyroidism, and extra-endocrine features. MEN2 syndrome includes two clinically distinct forms subtyped as MEN2A and MEN2B. Nearly all MEN2 cases are caused by germline mutations of the RET proto-oncogene. In this review, we propose "5P" strategies for management of MEN2: prevention, prediction, personalization, psychological support, and participation, which could effectively improve clinical outcomes of patients. Based on RET mutations, MEN2 could be prevented through prenatal diagnosis or preimplantation genetic testing. Identification of pathogenic mutations in RET can enable early diagnosis of MEN2. Combining RET mutation testing with measurement of serum calcitonin, plasma or urinary metanephrine/normetanephrine, and serum parathyroid hormone levels could allow risk stratification and accurately prediction of MEN2 progression, thus facilitating implementation of personalized precision treatments to increase disease-free survival and overall survival. Furthermore, increased awareness of MEN2 is needed, which requires participation of physicians, patients, family members, and related organizations. Psychological support is also important for patients with MEN2 to promote comprehensive management of MEN2 symptoms. The "5P" strategies for management of MEN2 represent a typical clinical example of precision medicine. These strategies could effectively improve the health of MEN2 patient, and avoid adverse outcomes, including death and major morbidity, from MEN2.

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Section: Personalized Precision Treatment Of Men2mentioning

confidence: 99%

5P Strategies for Management of Multiple Endocrine Neoplasia Type 2: A Paradigm of Precision Medicine

Ding

et al. 2020

Front. Endocrinol.

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“…Tumor multifocality and preoperative calcium levels were predictive for postoperative hypoPTH, and young age at diagnosis and low preoperative calcium levels were risk factors for persistent The frequency of overall postoperative hypoPTH (43.9%) in this study was higher than that observed in previously published reports. The frequencies of transient and permanent hypoPTH in pediatric thyroid cancer patients were reported to be 7.4~33.1% and 0~23.8% in previous studies [8][9][10][11][12][13][14][15][16][17][18] . The incidence rate differs depending on the indication or extent of surgery, lymph node dissection modalities, area of study conduction and follow-up duration [9][10][11][12][13][14][15][16][17][18][19]22,24) , as well as variable definitions of hypoPTH using different time points (6 months after operation 11,12,15,24) , 1 year after operation 22) or at last follow-up 9) ), biochemical values (serum calcium 15) , ionized calcium 25) or PTH levels 9,10) ) or treatment requirements (active vitamin D and/or calcium 11,12,16,22,24) supplementation postoperatively).…”

Section: Discussionmentioning

confidence: 99%

“…The frequencies of transient and permanent hypoPTH in pediatric thyroid cancer patients were reported to be 7.4~33.1% and 0~23.8% in previous studies [8][9][10][11][12][13][14][15][16][17][18] . The incidence rate differs depending on the indication or extent of surgery, lymph node dissection modalities, area of study conduction and follow-up duration [9][10][11][12][13][14][15][16][17][18][19]22,24) , as well as variable definitions of hypoPTH using different time points (6 months after operation 11,12,15,24) , 1 year after operation 22) or at last follow-up 9) ), biochemical values (serum calcium 15) , ionized calcium 25) or PTH levels 9,10) ) or treatment requirements (active vitamin D and/or calcium 11,12,16,22,24) supplementation postoperatively). Since there has been variable definition of postsurgical hypoPTH and the study protocols in each institution showed heterogeneities, the incidence rate of hypoPTH differs significantly which makes it hard to compare rates across studies.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with permanent hypoPTH had an increased risk of long-term morbidity in association with renal, cardiovascular diseases 7,8) . The prevalence of postoperative hypoPTH after pediatric thyroid surgery varied from 0 to 36.4% [9][10][11][12][13][14][15][16][17][18][19] depending on the indication of surgery, extent of lymph node dissection or definition of hypoPTH. Although several studies conducted with a large number of pediatric thyroid cancer patients in other countries revealed risk factors of hypoPTH including central neck dissection (CND) or extent of surgery 9,11,17) , no pediatric study has been conducted in Korea.…”

Section: Introductionmentioning

confidence: 99%

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Risk factors of postoperative hypoparathyroidism after total thyroidectomy in pediatric patients with thyroid cancer

Choe

Lee

Shin

et al. 2023

Ann Pediatr Endocrinol Metab

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Hypoparathyroidism is the most common complication following thyroidectomy. We investigated the frequency and risk factors of hypoparathyroidism after total thyroidectomy in pediatric patients with thyroid cancer.Methods: This retrospective study included 98 patients, diagnosed with thyroid cancer after total thyroidectomy < 20 years of age during 1990-2018 and followed up more than 2 years at Seoul National University Hospital. Hypoparathyroidism was defined as receiving active vitamin D (1-hydroxycholecalciferol or 1,25-dihydroxycholecalciferol) after surgery. Results:The study included 27 boys (27.6%) and 71 girls (72.4%). The mean age at diagnosis was 14.9 ± 3.7 years. Hypoparathyroidism occurred in 43 (43.9%) patients. Twenty-one (21.4%) patients discontinued active vitamin D less than 6 months, and 14 (14.3%) continued active vitamin D for more than 2 years. The risk for developing hypoparathyroidism immediately after total thyroidectomy was significantly higher in patients with multifocal tumor (Odds ratio (OR) 3.7 vs. single tumor, P= 0.013), and those with low preoperative calcium levels (OR 0.2, P=0.028). In addition, age (OR 0.8, P=0.011) and preoperative calcium levels (OR 0.04, P=0.014) significantly decreased the risk for persistent hypoparathyroidism requiring active vitamin D for more than 2 years. Conclusion:Hypoparathyroidism occurred in about two-fifth after total thyroidectomy in pediatric thyroid cancer. Among them, one-third of patients continued active vitamin D medication for more than 2 years, which was predicted by young age and low preoperative calcium levels.

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“…In addition, it has been shown that surgical treatment for patients with distant metastasis (including lung, bone, and brain metastases) is ineffective or detrimental. [5][6][7][8][9] In addition it, there is a need for development of alternative therapeutic interventions to treat and control the progression of FTC.…”

Section: Introductionmentioning

confidence: 99%

Resveratrol Inhibits the Tumorigenesis of Follicular Thyroid Cancer via ST6GAL2-Regulated Activation of the Hippo Signaling Pathway

Chen

Wang

et al. 2020

Molecular Therapy - Oncolytics

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Follicular thyroid carcinoma (FTC) is a common endocrine malignancy with highly aggressive features. In this study, next-generation sequencing technology was used to identify aberrant expression of sialyltransferase (ST) family members in FTC. Aberrant high expression of alpha-2,6-sialyltransferase 2 (ST6GAL2) was demonstrated to promote tumorigenesis of FTC in vitro and in vivo. Furthermore, ST6GAL2 promoted tumorigenesis by inactivating the Hippo signaling pathway. Resveratrol is a native compound extracted from Vitis species, and many studies have confirmed its protective cardiovascular and antineoplastic effects. Here we found that resveratrol can inhibit the tumorigenesis of FTC by suppressing the expression of ST6GAL2, further activating the Hippo pathway. In summary, this study revealed the role of the ST6GAL2-Hippo signaling pathway in FTC tumorigenesis and indicated that resveratrol, a commonly found antineoplastic compound, could inhibit tumorigenesis of FTC by regulating the abovementioned pathways.Recently, sialyltransferase (ST) families have been reported to be critical cancer-regulating factors. 10 Sialylation is a key process in eukaryotic cells that has been shown to act in cell recognition, cell adhesion, receptor activation, and protein stability. 11 Therefore, STs contribute greatly to tumor development by acting as catalysts of sialylation. STs are categorized into four families: ST3GAL, ST6GAL, ST6GALNAC, and ST8SIA. 12 As reported, ST6GAL1 and ST3GAL6 regulate tumorigenesis of human colorectal carcinoma, 13,14 ST6GALNAC2 regulates breast cancer invasion, 15 and ST8SIA2 regulates cell invasion of non-small cell lung cancer. 16 Moreover, similar findings were reported in our previous study, which showed that alpha-2,6-sialyltransferase 2 (ST6GAL2) is highly expressed in FTC and regulated by the long noncoding RNA-HLA complex P5 (HCP5). 17 However, the downstream regulatory mechanisms of ST6GAL2 in FTC are not clear.

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Risk factors of post-surgery complications in children with thyroid cancer

Cited by 7 publications

References 42 publications

5P Strategies for Management of Multiple Endocrine Neoplasia Type 2: A Paradigm of Precision Medicine

5P Strategies for Management of Multiple Endocrine Neoplasia Type 2: A Paradigm of Precision Medicine

Risk factors of postoperative hypoparathyroidism after total thyroidectomy in pediatric patients with thyroid cancer

Resveratrol Inhibits the Tumorigenesis of Follicular Thyroid Cancer via ST6GAL2-Regulated Activation of the Hippo Signaling Pathway

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