Risk Factors of Ovarian Metastasis from Colorectal Cancer by Using Multivariate Analysis

Tomiki, Yuichi; Kamano, Toshiki; Kunii, Y; Okada, Tsuyoshi; Kasamaki, Shinji; Negami, Naoki; Orita, Hajime; Sakamoto, Shuichi; Sakamoto, Kazuhiro; Takahashi, Masahīko

doi:10.5833/jjgs.35.11

Cited by 15 publications

(6 citation statements)

References 8 publications

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“…Metastases to ovaries from CRC occur in 1.6%-6.4% of all female CRC patients. The risk factors of the onset of ovarian metastases from CRC reportedly include CRC before menopause, tumor invasion beyond T3, peritoneal metastases, and morphological abnormalities of the ovary [5]. The Japanese Classification of Colorectal Carcinoma and TMN classification classifies ovarian metastasis as distant metastasis.…”

Section: Discussionmentioning

confidence: 99%

“…In our series, the five-year OS rate of Group Ov was 50%. Ovarian metastasis from primary CRC was previously classified under peritoneal metastasis and thought to be associated with a poor prognosis [5,6]. However, peritoneal metastasis is an adverse prognostic factor, and R0 resection of ovarian metastasis without peritoneal metastasis is associated with an increased OS time.…”

Section: Discussionmentioning

confidence: 99%

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The Validity of a New Edition of Classification for Ovarian Metastasis from Colorectal Cancer

Yoshihara

Noura

Tanida

et al. 2021

J Anus Rectum Colon

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Objectives: In the 9th edition of the Japanese Classification of Colorectal, Appendiceal, and Anal Carcinoma (JCCRC), ovarian metastasis is classified as distant metastasis. We assessed the significance of resection of ovarian metastases and the validity of this 9th edition of JCCRC for ovarian metastases from colorectal cancer (CRC). Methods: We retrospectively analyzed the clinicopathological factors and overall survival of 17 patients with ovarian metastases from CRC who underwent resection and 110 female CRC patients with Stage IV (M1a) disease. Results: The patients with only ovarian metastases who underwent resection had a longer median survival time than patients with both ovarian and peritoneal metastases who underwent resection (45.4 months vs. 9.3 months, P = 0.029). The 5-year overall survival of the patients with only ovarian metastases who underwent R0 resection was as long as that of the female Stage IV (M1a) CRC patients after R0 resection (50% vs. 48%, P = 0.334). Conclusions: We found that, after resection, patients with only ovarian metastases had significantly better prognoses than patients with ovarian and peritoneal metastases. R0 resection of ovarian metastasis indicated as good prognosis as R0 resection of metastasis to one distant organ without ovaries. So the 9th edition of JCCRC, which classifies ovarian metastasis from CRC as distant metastasis, is appropriate.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Validity of a New Edition of Classification for Ovarian Metastasis from Colorectal Cancer

Yoshihara

Noura

Tanida

et al. 2021

J Anus Rectum Colon

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“…[ 7 ] However, one report stated a 5-year survival rate after resection of 67.5% in patients with only ovarian metastasis and no other peritoneal dissemination or distant metastasis. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

Laparoscopically diagnosed and treated ruptured metastatic ovarian tumor

Nishimura

Matsumoto

Ohara

et al. 2020

Gynecol Minim Invasive Ther

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A 51-year-old woman visited our institution with a chief complaint of abdominal pain. Blood laboratory testing revealed a carcinoembryonic antigen level of 13.4 ng/mL. Magnetic resonance imaging revealed a massive pelvic mass with marked wall thickening, partly accompanied by a high-signal-intensity cystic component in T2-weighted images. The entire tumor had low-signal intensity in T1-weighted images. We diagnosed a ruptured ovarian tumor, and the patient underwent emergent laparoscopic left salpingo-oophorectomy. Pathological examination revealed metastatic colon cancer to the ovary, and lower gastrointestinal endoscopy confirmed sigmoid colon carcinoma. Laparoscopic sigmoidectomy was performed followed by adjuvant chemotherapy with capecitabine + oxaliplatin. Ruptured metastatic ovarian tumor is extremely rare. With early diagnosis and laparoscopic resection, the primary lesion can be identified and treated quickly.

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“…Former studies suggested that there are three possible routes of metastasis for colon cancer to the ovary: the lymphatic vessels, blood vessels, and peritoneal dissemination. Sato et al [ 11 ] and Tomiki et al [ 12 ] supported the theory of metastasis through blood vessels due to the lack of lymphatic connection between colon and ovary, but Samanth and Black 3rd [ 13 ] and Lemming [ 14 ] have supported a lymphatic metastasis theory because of the pathological features of colon cancer lymphatic invasion in cases with ovarian metastasis. On the other hand, Terada et al [ 15 ] reported that multivariate analysis identified age (premenopausal), morphological abnormalities of the ovary, depth of tumor invasion, and peritoneal metastasis as factors significantly associated with ovarian metastasis from colorectal cancer.…”

Section: Discussionmentioning

confidence: 99%

Three Cases of Pseudo-Meigs’ Syndrome Secondary to Ovarian Metastases from Colorectal Cancer

Yamamoto

Miyagawa

Ehara

et al. 2017

Case Reports in Surgery

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Pseudo-Meigs' syndrome is used to describe cases of ascites and/or pleural effusion associated with ovarian neoplasms other than benign tumors, which improve after removal of the ovarian lesion. We present three cases of pseudo-Meigs' syndrome secondary to ovarian metastasis from colorectal cancer. In case 1, the patient has severe dyspnea and hypoxia due to massive right pleural effusion; therefore preoperative thoracic drainage was needed. In case 2, the patient needed paracentesis every two or three days to improve abdominal distension. After two courses of 5-fluorouracil, levofolinate, and oxaliplatin (mFOLFOX6), her ascites could be controlled by diuretics without aspiration and her general condition improved. Then she underwent operation. In case 3, the patient developed a massive pleural effusion and ascites coincident with a rapid enlargement of ovarian tumor after resection and adjuvant chemotherapy for rectal cancer. In all cases, pleural effusions and/or ascites resolved and general conditions and daily activities of the patients improved after oophorectomy. They are all currently in good health without recurrence of pleural effusion or ascites. In patients with suspected pseudo-Meigs' syndrome secondary to ovarian metastasis of colorectal cancer, operation including oophorectomy may reduce pleural effusions and/or ascites and improve the general condition.

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Risk Factors of Ovarian Metastasis from Colorectal Cancer by Using Multivariate Analysis

Cited by 15 publications

References 8 publications

The Validity of a New Edition of Classification for Ovarian Metastasis from Colorectal Cancer

The Validity of a New Edition of Classification for Ovarian Metastasis from Colorectal Cancer

Laparoscopically diagnosed and treated ruptured metastatic ovarian tumor

Three Cases of Pseudo-Meigs’ Syndrome Secondary to Ovarian Metastases from Colorectal Cancer

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