Risk factors of osteopenia in HIV-infected women: No role of antiretroviral therapy

HIV-1 infection and antiretroviral therapies: risk factors for osteoporosis and bone fracture

“…Recently, Yin et al [7•] report that premenopausal HIV-positive women display lower BMD than comparable HIV-negative women; however, BMD did not correlate with use or class of antiretrovirals. Similar data were reported by Libois et al [32•] who found that osteopenia and osteoporosis was highly prevalent among HIV-infected premenopausal women, but loss of BMD was not associated with antiretroviral therapy. Furthermore, Brown et al [33•] reported that loss of BMD after HAART initiation occurred independently of the antiretroviral regimen, and Grund et al [34•] reported that continuous HAART was associated with a decline in BMD and possibly more fractures relative to intermittent HAART, but likewise reported no consistent drugspecific association.…”

Bone, fracture and frailty

“…The sample size was too small to identify predictors of increased bone loss by ART exposure or individual components of ART regimens [23]. The lack of an association between ART exposure, and specific ART regimens was reported in another underpowered cross-sectional study in premenopausal women [24].…”

An increased risk of osteoporosis in a HIV-infected patient in the era of HAART. Case report analysis

“…It seems that the exams should be conducted earlier. Only few data are available in women [38]. HIV-infected patients, especially men, are more likely to be hypogonadal, and the presence of hypogonadism significantly increases the risk of osteoporosis in these patients [39].…”