Risk factors of neural tube defects: A reality of Batna region in Algeria

Bourouba, Romyla; Houcher, Bakhouche; Akar, Nejat

doi:10.1016/j.ejmhg.2017.10.003

Cited by 12 publications

(16 citation statements)

References 29 publications

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“…In our study, consanguinity was notified in different types of NTDs with an estimated rate of 34% and even 80% in first degree cases. This is a higher rate than the one observed by Bourouba et al in Algeria where the consanguinity rate was 30% [ 9 ], and by Golalipour et al in Iran who reported a rate of 28% [ 29 ]. The consumption of fenugreek and other plants was primarily related to cases of anencephaly and spina bifida.…”

Section: Discussionmentioning

confidence: 63%

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

et al. 2021

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Background Neural tube defects (NTDs) are a group of birth defects that result from a partial or complete failure of the neural tube to close during embryogenesis. Their prevalence varies between 0.5 to 2 per 1000 births in countries without folic acid supplementation. The aim of our study is to assess the NTDs incidence and describe the risk factors within Moroccan newborn infants. Method This is a descriptive study over a period of 5 and a half years including all births at “Les Orangers” Maternity and Reproductive Health Hospital of Rabat with notification of NTD cases, whether isolated or combined with other anomalies. Data were reported on pre-established sheets and on the teratovigilance registry. Statistical analysis was performed with SPSS version 18 statistical software. Results During the study period, 43,923 births were recorded including 44 cases of neural tube defects, an incidence rate of 1 per 1000 births, with a female predominance; sex ratio = 0.8. These defects included anencephaly (50%), spina bifida (38.6%) and encephalocele (11.4%). The risk factors detected during this study include consanguinity (34%), consumption of fenugreek or other plants (36%), diabetes (4.5%) and medication (2.2%). A family history of malformation was reported in 6.8% of cases and among siblings in 4.5% of cases. The average maternal age was 30.38 ± 6.88 and the average gestational age was 36.80 ± 5.11. A quarter of mothers did not benefit from any medical monitoring during pregnancy while 59% did not take folic acid supplementation during the first trimester of pregnancy and none of them took B9 vitamin during the periconceptional period. The antenatal diagnosis was performed in 63% of cases. The mortality rate was 3.8 per 10,000 and 16% of cases evolved positively. Conclusion NTDs require high intensity and multidisciplinary care which stresses the importance, in our context, of strengthening and optimizing acid folic supplementation strategies during the periconceptional period.

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Section: Discussionmentioning

confidence: 63%

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

et al. 2021

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“…The total number of participants included was 6086, 384. Ten studies had been conducted in Ethiopia [2, 5, 9-11, 17-20, 64], five in Tunisia [3,8,[21][22][23], eight in Nigeria [6,12,15,16,50,51,65,66], two in Algeria [4,7], six in South Africa [55,59,60,63,67,68], two in Sudan [48,62], and two in Ghana [49,57]. Study was conducted in Kenya [13], Eritrea [14], Libya [52], Egypt [53], Cameron [54], Malawi [58], Tanzania [61], and Democratic Republic (DR) of Congo [47] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

“…The period prevalence, birth outcome, study setting, and study quality were presented in Table 2. In addition to studies explained in Table 2, studies done by Atlaw et al [18], Berihu et al [19], Aynalem et al [20], Nasri et al [21], Bourouba et al [4], Kitova et al [22], and Nasri et al [23] were declared low risk.…”

Section: Resultsmentioning

confidence: 99%

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Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

2021

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Background Neural tube defects are common congenital anomalies that result from early malformation in the development of the spinal cord and brain. It is related to substantial mortality, morbidity, disability, and psychological and economic costs. The aim of this review is to determine the pooled birth prevalence of neural tube defects and associated risk factors in Africa. Methods The first outcome of this review was the pooled birth prevalence of the neural tube defects and the second outcome was the pooled measure of association between neural tube defects and associated risk factors in Africa. We systematically searched PubMed, PubMed Central, Joanna Briggs Institute, Google Scopus, Cochrane Library, African Journals Online, Web of Science, Science Direct, Google Scholar, and Medline databases. The heterogeneity of studies was assessed using the Cochrane Q test statistic, I2 test statistic, and, visually, using Forest and Galbraith’s plots. A random-effect model was applied to get the pooled birth prevalence of neural tube defects. Subgroup, sensitivity, meta-regression, time-trend, and meta-cumulative analyses were undertaken. The fixed-effect model was used to analyze the association between neural tube defects and associated risk factors. Results Forty-three studies with a total of 6086,384 participants were included in this systematic review and meta-analysis. The pooled birth prevalence of the neural tube defects was 21.42 (95% CI (Confidence Interval): 19.29, 23.56) per 10,000 births. A high pooled birth prevalence of neural tube defects was detected in Algeria 75 (95% CI: 64.98, 85.02), Ethiopia 61.43 (95% CI: 46.70, 76.16), Eritrea 39 (95% CI: 32.88, 45.12), and Nigeria 32.77 (95% CI: 21.94, 43.59) per 10,000 births. The prevalence of neural tube defects has increased over time. Taking folic acid during early pregnancy, consanguineous marriage, male sex, and substance abuse during pregnancy were assessed and none of them was significant. Conclusions The pooled birth prevalence of neural tube defects in Africa was found to be high. The risk factors evaluated were not found significant.

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“…For this reason, in some cases, folic acid intake is not a sufficient measure when pregnancy is diagnosed. The addition of folic acid to the diet (400mcg daily) for 3 months preconception and during first trimester reduces the risk of spina bifida by about 75% [11,38].…”

Section: Intracranial Anatomy In Spina Bifida Apertamentioning

confidence: 99%

Open Neural Tube Defects: A Case Presentation of 30-year-old Secundigravida with Spina Bifida of the Fetus

Anzhel

Kovachev

Tonchev

et al. 2021

COGO

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Spina bifida is a neural tube defect that occurs in about 1 in 1,500 pregnancies. Open spinal defects are associated with paralysis, incontinence and hydrocephalus requiring postnatal shunting of the cerebrospinal fluid. Neural tube defects are preventable through preconceptional folic acid supplementation. Occasionally, the diagnosis is made during routine anomaly scan at 18-20 weeks of gestation, as the earliest signs of the anomaly can be seen at the end of first trimester. The information provided by ultrasound plays a crucial role in patient counseling and pregnancy management. The authors report a case of prenatal diagnosis of spina bifida aperta with focus on detailed ultrasound presentation and difficulties in consulting in relation to the prognosis for the newborns.

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Risk factors of neural tube defects: A reality of Batna region in Algeria

Cited by 12 publications

References 29 publications

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

Incidence of neural tube defects and their risk factors within a cohort of Moroccan newborn infants

Birth prevalence of neural tube defects and associated risk factors in Africa: a systematic review and meta-analysis

Open Neural Tube Defects: A Case Presentation of 30-year-old Secundigravida with Spina Bifida of the Fetus

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