Risk factors of myelodysplastic syndromes: a case–control study

Strom, Sara S.; Gu, Yun; Gruschkus, Stephen K.; Pierce, Sherry; Estey, Elihu H.

doi:10.1038/sj.leu.2403945

Cited by 123 publications

(113 citation statements)

References 39 publications

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“…35 Strom et al could show a joint effect between smoking and chemical exposure with the highest risk among smokers exposed to solvent/agricultural chemicals. 31 Recently, Sekeres described advanced age, male gender, smoking and previous exposure to chemotherapy, radiation therapy or exposure to industrial chemicals as the most common risk factors for developing MDS. 36 In our study, no significant differences in dysmyelopoiesis could be attributed to smoking habits.…”

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confidence: 99%

Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors

Parmentier¹,

Schetelig²,

Lorenz³

et al. 2011

Haematologica

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BackgroundAccording to WHO 2008 guidelines, the required percentage of cells manifesting dysplasia in the bone marrow to qualify as significant is 10% or over in one or more hematopoietic cell lineages, but this threshold is controversial. No 'normal' values have been established. Therefore, we investigated dyshematopoiesis in bone marrow aspirate squash preparations of 120 healthy bone marrow donors. Design and MethodsBone marrow squash slides of 120 healthy unrelated bone marrow donors were examined independently by 4 experienced morphologists. Samples were taken from the first aspiration during the harvest. Bone marrow preparation and assessment were performed according to WHO recommendations and ICSH guidelines. ResultsMore than 10% dysmyelopoiesis could be detected in 46% of bone marrow aspirate squash preparations with 26% in 2 or more cell lineages and 7% in 3 cell lineages in healthy bone marrow donors. Donors under the age of 30 years exhibited more dysgranulopoietic changes and dysmegakaryopoietic changes (P<0.001) compared to the older donors. Female donors showed more dysgranulopoietic changes than male donors (P=0.025). The concordance rate between the 4 investigators was modest in dysgranulopoiesis but poor in dyserythropoiesis and dysmegakaryopoiesis. ConclusionsThe poor reliability of the 10% cut off was partly related to the proximity of the current criteria to the observed cut-off mean values of the normal population. These findings question the current WHO threshold of the 10% or over necessary for the percentage of cells manifesting dysplasia to be considered significant, and suggest that either a higher threshold would be more appropriate or different thresholds should be set for each lineage.Key words: dysplasia, hematopoiesis, cut off, significant, percentage, bone marrow donors.Citation: Parmentier S, Schetelig J, Lorenz K, Kramer M, Ireland R, Schuler U, Ordemann R, Rall G, Schaich M, Bornhäuser M, Ehninger G, and

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Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors

Parmentier¹,

Schetelig²,

Lorenz³

et al. 2011

Haematologica

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“…Myelodysplastic syndrome is a heterogeneous clonal haematological disorder that can progress to AML. Cigarette smoking (Nisse et al, 2001), solvent exposure (Nisse et al, 2001) and agricultural exposures (Strom et al, 2005) have all been associated with an increased risk of MDS, and senescence of the haematopoietic system is thought to play a role in its development (Dalamaga et al, 2002). Less is known about the causes of MPDs, including polycythemia vera and essential thrombocythemia.…”

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confidence: 99%

Risks of myeloid malignancies in patients with autoimmune conditions

et al. 2009

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Autoimmune conditions are associated with an elevated risk of lymphoproliferative malignancies, but few studies have investigated the risk of myeloid malignancies. From the US Surveillance Epidemiology and End Results (SEER)-Medicare database, 13 486 myeloid malignancy patients (aged 67 þ years) and 160 086 population-based controls were selected. Logistic regression models adjusted for gender, age, race, calendar year and number of physician claims were used to estimate odds ratios (ORs) for myeloid malignancies in relation to autoimmune conditions. Multiple comparisons were controlled for using the Bonferroni correction (Po0.0005).

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“…Although the exact link between alcohol and MDS is not yet clear, it is reported that alcoholics induce chromosomal abnormalities in hematopoietic cells with altered gene expression patterns and adverse effects on the immune system [9,10,11]. Tobacco products like cigarettes which contain benzene and other carcinogens also induce chromosomal aberrations in primitive bone marrow cells leading to development of MDS [9,12,13].…”

Section: Introductionmentioning

confidence: 99%

“…These genetic abnormalities occur due to previous exposure to mutagens like benzene, alkylating agents, gasoline, topoisomerase II inhibitors, radiation etc. [7][8][9][10][11][12][13]. Due to exposure to insecticides, pesticides and herbicides agricultural workers are reported to have higher incidence of developing MDS [7].…”

Section: Introductionmentioning

confidence: 99%

Development of Cytogenetic Abnormalities in Myelodysplastic Syndromes

WMMS¹,

AJIS²

2016

J Mol Genet Med

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Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic stem cell disorders characterized by ineffective hematopoiesis resulting in cellular dysplasia and peripheral cytopenias. Research into MDS have found that both hematopoietic stem cells (HSCs) and mesenchymal stem cells (MSCs) in the nurturing niche of HSCs are genetically altered in MDS. In this review we present the existing views on the origin of cytogenetic abnormalities in HSC and MSC compartments in MDS. Based on the available data, we speculate that the origin of the chromosomal aberrations of the hematopoietic compartment occurs at the hematopoietic stem/ progenitor level. The genetic aberrations in MSC compartment appears to initiate independently from their hematopoietic counterparts. Whether the genetic events in both HSC and MSC compartments which lead to MDS occur simultaneously or at different time points in the disease development need to be determined in future.

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Risk factors of myelodysplastic syndromes: a case–control study

Abstract: Little is known about the etiology of myelodysplastic syndromes (MDS) .

Cited by 123 publications

References 39 publications

Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors

Assessment of dysplastic hematopoiesis: lessons from healthy bone marrow donors

Risks of myeloid malignancies in patients with autoimmune conditions

Development of Cytogenetic Abnormalities in Myelodysplastic Syndromes

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