Risk factors of Multidrug Resistant Tuberculosis in central Nepal: A pilot study

Marahatta, Sujan Babu; Kaewkungwal, Jaranit; Ramasoota, Pongrama; Singhasivanon, Pratap

doi:10.3126/kumj.v8i4.6238

Cited by 31 publications

(34 citation statements)

References 18 publications

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“…This result is in corresponds with other studies. [13][14][15] However, present study showed that there was no significant association of both age and gender wise distribution with pattern of pulmonary tuberculosis. On smoking-wise distribution, smokers were found more susceptible to pulmonary tuberculosis than non-smokers which was in accordance with other studies.…”

Section: Discussionmentioning

confidence: 64%

Evaluation of Gene Xpert Mtb/Rif Assay for the Detection of Mycobacterium Tuberculosis in Sputum of Patients Suspected of Pulmonary Tuberculosis Visiting National Tuberculosis Centre, Thimi, Bhaktapur, Nepal

Thapa

Gurung

Ghimire

2017

SAARC J. Tuber. Lung Dis. HIV/AIDS

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introduction: Tuberculosis (TB) is one of the most deadly and common major infectious diseases in developing countries. Rapid and accurate diagnosis of tuberculosis is indispensable to adequately manage the disease and control its transmission. The objective of this study was to evaluate Gene Xpert MTB/RIF Assay for detection of M. tuberculosis in sputum of patients suspected of pulmonary tuberculosis and its comparison with traditional conventional methods.

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Section: Discussionmentioning

confidence: 64%

Evaluation of Gene Xpert Mtb/Rif Assay for the Detection of Mycobacterium Tuberculosis in Sputum of Patients Suspected of Pulmonary Tuberculosis Visiting National Tuberculosis Centre, Thimi, Bhaktapur, Nepal

Thapa

Gurung

Ghimire

2017

SAARC J. Tuber. Lung Dis. HIV/AIDS

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“…Statistical Package for Social Sciences (SPSS) version 21 for windows was used to analyze the data. Then, the association between categorical variable was assessed by chi-square ( 2) test (Marahatta et al 2010). A result was considered significant at a P value <0.05.…”

Section: Data Collection Analysis and Interpretationmentioning

confidence: 99%

“…A result was considered significant at a P value <0.05. Odd ratio (OR) were calculated to evaluate the magnitude of association between risk factors and MDR-TB (Marahatta et al 2010).…”

Section: Data Collection Analysis and Interpretationmentioning

confidence: 99%

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Risk Factors of Multidrug-Resistant Tuberculosis

Rumende

2017

Int J Appl Sci Biotechnol

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Multidrug-resistant tuberculosis has been increased worldwide which is a severe problem. A case-control study was carried out among 50 MDR-TB cases and 63 drug susceptible controls to identify risk factors associated with multidrug-resistant tuberculosis (MDR-TB) in Lumbini Zone. Irregularity in taking medicine (OR=2.36), large family size (OR=2.40), farming as occupation (OR=2.83), history of TB and bovine at home (OR=6.5) were statistically associated with MDR-TB. Most of the MDR-TB cases were males (82%) and individual with the age group 21-30 years (40%) were highly infected with MDR-TB.

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“…Previous TB treatment, smoking habit, alcoholism, poverty, poor housing, overcrowding, homelessness, illiteracy and migration from/to high DRTB prevalence areas are other common reasons for the development of drug resistance [24][25] tuberculosis.…”

Section: -22mentioning

confidence: 99%

Treatment Outcome of Drug Resistance Tuberculosis From a Centre of Eastern Region, Nepal

Ghimire

Rimal

Parajuli

2017

Birat J. Health Sci.

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Introduction Drug resistance tuberculosis (DRTB) has become major problem worldwide with difficulty in treatment. Objective The study is conducted to find the incidence and outcomes of DRTB in one of the eastern tuberculosis treatment centre of Nepal.Methodology We collected all the cases of DRTB being treated from national anti-tuberculosis association of Biratnagar, Nepal. There were altogether 154 patients, who had sputum culture with resistance of at least one anti tubercular drug (ATD), included in this study.Results Of 154 total patients, 36 patients were resistant to rifampicin only, 84 patients were resistant to isoniazid and rifampicin, 18 patients were resistant to isoniazid, rifampicin and ethambutol and 16 patients were resistant to isoniazid, rifampicin and either streptomycin or fluoroquinolone. There was overall 71% cure rate in case of drug resistance tuberculosis. There was only statistical difference between cured and died patients in case of sputum conversion time with earlier sputum conversion in cured patients. Similarly, patients who were previously treated with category 2 ATD had only resistance to ethambutol or streptomycin or fluoroquinolone besides resistance to isoniazid and rifampicin compared to new patients and patients treated with category 1 regimen; as these groups were not found to be resistant to first three drugs.Conclusion There was overall 71% cure rate in case of drug resistance tuberculosis. Earlier sputum conversion was seen in cured patients compared to those who died during the treatment. Multiple drugs were resistant in patients previously treated with category 2 Anti-tubercular drugs.Birat Journal of Health Sciences 2016 1(1): 20-26

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Risk factors of Multidrug Resistant Tuberculosis in central Nepal: A pilot study

Abstract: Introduction

Cited by 31 publications

References 18 publications

Evaluation of Gene Xpert Mtb/Rif Assay for the Detection of Mycobacterium Tuberculosis in Sputum of Patients Suspected of Pulmonary Tuberculosis Visiting National Tuberculosis Centre, Thimi, Bhaktapur, Nepal

Evaluation of Gene Xpert Mtb/Rif Assay for the Detection of Mycobacterium Tuberculosis in Sputum of Patients Suspected of Pulmonary Tuberculosis Visiting National Tuberculosis Centre, Thimi, Bhaktapur, Nepal

Risk Factors of Multidrug-Resistant Tuberculosis

Treatment Outcome of Drug Resistance Tuberculosis From a Centre of Eastern Region, Nepal

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