Risk factors of local relapse in breast cancer: the importance of age

Algara, Manuel; Latiesas, Xavier Sanz; Arnalot, Palmira Foro; Bassols, M. Lacruz; Castillejo, A. Reig; Jordana, Jacint; Membrive, I.; Lozano, J.; Dios, N. Rodriguez De

doi:10.1007/s12094-007-0021-8

Cited by 12 publications

(4 citation statements)

References 46 publications

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“…Infiltrating duct carcinoma (IDC) is considered by Lopez et al to be one of the risk factors for recurrence. This is clear in our results, where IDC was the main histopathology (90.1% for group I and 80.6% for group II) [13].…”

Section: Discussionsupporting

confidence: 67%

“…For patients ≤40 years old, the relative risk of locoregional recurrence was 5.27 and 3.7 with regards to patients aged 41-50 years and patients older than 50 years old, respectively. They concluded that patients ≤40 years old have a higher risk of local failure than older patients; factors other than age, for instance, close margins, intraductal component, and size of tumour can be masked by the effects of a higher dose of radiotherapy [13].…”

Section: Discussionmentioning

confidence: 99%

“…The age of the patient has been regarded as an independent risk factor for the development of locoregional recurrence after surgical management of BC and is regarded as strong as margin affection for patients under the age of 40 years [13]. Age is the most important risk factor for the appearance of local relapse after preservation treatment, but not after mastectomy [14][15].…”

Section: Introductionmentioning

confidence: 99%

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Impact of Molecular Profiling of Breast Cancer on the Rate of Locoregional Recurrence in Young Versus Old Female Patients

Soliman¹,

Abouelazayem²,

Elkorety³

et al. 2021

Cureus

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BackgroundBreast cancer (BC) is diverse regarding its natural history and treatment responses. The traditional histopathological classification is unable to confine this diverse clinical heterogeneity. Classically, prognosis and treatment response are influenced by factors including histological grade, lymph node status, and tumour size. Recently, research has diverted from histological classification towards molecular classification.We aim to analyse the locoregional recurrence of breast cancer incidence following surgery across the different molecular subtypes as well as relation to age. Materials and methodsFemale patients diagnosed with a locoregional recurrence of breast carcinoma in 2012-2014 were identified from our centre histology department. We only included stage I-III patients who were previously treated with surgery achieving negative surgical margins and later developed locoregional recurrence during our study period. These patients were subdivided by age into old (≥40 years old) and young (<40 years old) groups according to their initial diagnosis age. Furthermore, they were categorised according to the molecular subtype of their primary tumour. ResultsOur study included 184 patients (124 designated to the old age group, 60 to the young age group). In the young group, recurrence occurred after a mean of 4.3 years and the range was one to 23 years, while in the old group, the mean was 3.8 years, and the range was one to 14 years. The most primary cancer subtype recorded was triple-negative (41.85%): 50 old patients and 27 young. Next was the Her-2/neu enriched subtype (27.72%): 35 old patients and 16 young, following this was luminal A subtype (21.19%): 27 old and 12 young. Last was the luminal B subtype (9.24%): 12 old patients and five young. ConclusionsTo conclude, in our series, the most common molecular subtype found in the recurrent cases was the luminal negative subtypes, with a relatively similar pattern across both age groups. The results of this study can be used as a basis for large prospective studies in our centre to further analyse the effect of molecular subtyping on the recurrence rates of BC.

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Section: Discussionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of Molecular Profiling of Breast Cancer on the Rate of Locoregional Recurrence in Young Versus Old Female Patients

Soliman¹,

Abouelazayem²,

Elkorety³

et al. 2021

Cureus

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“…These studies show that the incidence of local recurrence is significantly lower in the group of patients treated with radiotherapy, about an 8%–10% with respect to the nonirradiated ones in which the local recurrence reached 25%–35%, independently of other associated factors. One of the most important risk factors for the development of breast cancer is age [ 6 ]. Most cases are diagnosed between the ages of 35 and 80, nearly half of them diagnosed at the age of 70 or more years [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients

Martínez-Sanz

Zhao

Rodríguez

et al. 2018

BioMed Research International

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Purpose Radiation therapy is a key treatment of breast cancer. Elderly patients with associated diseases that modify their performance status do not tolerate long periods of daily irradiation. The objective of this study is to analyze the results of weekly hypofractionated treatment in these patients. Material and Methods Between 1992 and 2016, we included 486 elderly patients presenting concomitant pathology or sociofamilial problems in which it was not feasible to propose conventional treatment. They were treated with conservative surgery or mastectomy and then adjuvant hypofractionated irradiation, administering 5 Gy or 6.25 Gy in 6 fractions, once a week (total dose 30–37.5 Gy) over 6 weeks. Results Breast cancer overall survival according to the Kaplan-Meier method at 5 years was 74.2% ± 2.3%; breast cancer disease-free survival was 90% ± 1.6%; local relapse-free survival was 96.5% ± 1% showing that patients die more from other causes and not from their neoplasia. Acute dermatitis was mild (75.6% of the patients grades I–III) and 30.6% had moderate chronic fibrosis. Conclusions The once-weekly hypofractionated radiotherapy is a feasible and convenient option for elderly patients with breast cancer. It is a safe treatment modality with similar survival and local control results compared to standard fractionation, while the side effects are acceptable.

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Use of radiation treatment units in breast cancer. Changes in the last 15 years

et al. 2008

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Risk factors of local relapse in breast cancer: the importance of age

Abstract: Patients 40 years or younger have a higher risk of local failure than older patients. Other risk factors such as tumour size, intraductal carcinoma or margin status could be masked by an increase of radiation dose.

Cited by 12 publications

References 46 publications

Impact of Molecular Profiling of Breast Cancer on the Rate of Locoregional Recurrence in Young Versus Old Female Patients

Impact of Molecular Profiling of Breast Cancer on the Rate of Locoregional Recurrence in Young Versus Old Female Patients

Once-Weekly Hypofractionated Radiotherapy for Breast Cancer in Elderly Patients: Efficacy and Tolerance in 486 Patients

Use of radiation treatment units in breast cancer. Changes in the last 15 years

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