Risk Factors of In-Hospital Mortality in Non-Specialized Tertiary Center Repurposed for Medical Care to COVID-19 Patients in Russia

Кондаков, А. С.; Бердалин, А. Б.; Lelyuk, Vladimir; Gubskiy, Ilya; Golovin, Denis

doi:10.3390/diagnostics11091687

Cited by 2 publications

(4 citation statements)

References 63 publications

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“…With regard to the clinical results of our study, it should be noted that the risk factors in our population are similar to those previously reported in other articles and reviews, with the exception of arterial hypertension. We have discussed in detail the possible reasons for this in another article on risk factors in our patient cohort [27]…”

Section: Discussionmentioning

confidence: 99%

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Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

et al. 2021

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This study’s aim was to investigate CT (computed tomography) pattern dynamics differences within surviving and deceased adult patients with COVID-19, revealing new prognostic factors and reproducing already known data with our patients’ cohort: 635 hospitalized patients (55.3% of them were men, 44.7%—women), of which 87.3% had a positive result of RT-PCR (reverse transcription-polymerase chain reaction) at admission. The number of deaths was 53 people (69.8% of them were men and 30.2% were women). In total, more than 1500 CT examinations were performed on patients, using a GE Optima CT 660 computed tomography (General Electric Healthcare, USA). The study was performed at hospital admission, the frequency of repetitive scans further varied based on clinical need. The interpretation of the imaging data was carried out by 11 radiologists with filling in individual registration cards that take into account the scale of the lesion, the location, contours, and shape of the foci, the dominating types of changes, as well as the presence of additional findings and the dynamics of the process—a total of 45 parameters. Statistical analysis was performed using the software packages SPSS Statistics version 23.0 (IBM, Armonk, NY, USA) and R software version 3.3.2. For comparisons in pattern dynamics across hospitalization we used repeated measures general linear model with outcome and disease phase as factors. The crazy paving pattern, which is more common and has a greater contribution to the overall CT picture in different phases of the disease in deceased patients, has isolated prognostic significance and is probably a reflection of faster dynamics of the process with a long phase of progression of pulmonary parenchyma damage with an identical trend of changes in the scale of the lesion (as recovered) in this group of patients. Already known data on typical pulmonological CT manifestations of infection, frequency of occurrence, and the prognostic significance of the scale of the lesion were reproduced, new differences in the dynamics of the process between recovered and deceased adult patients were also found that may have prognostic significance and can be reflected in clinical practice.

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Section: Discussionmentioning

confidence: 99%

“…Summary of key epidemiological risk factors findings from the previously published article of our colleagues[27].…”

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confidence: 99%

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

et al. 2021

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“…Prior investigations have demonstrated dose-dependent associations between alcohol misuse and poorer outcomes in patients hospitalized with pneumonia including increased risk for prolonged hospital and ICU lengths of stay and development of the acute respiratory distress syndrome (ARDS) (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15). While changes in alcohol consumption have been consistently observed during the COVID-19 pandemic, the impact of alcohol misuse on healthcare outcomes related to COVID-19 are conflicted.…”

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confidence: 99%

“…Early in the COVID-19 pandemic, rates of alcohol use disorders (AUDs) accelerated for multiple reasons including increased isolation, use of alcohol as a coping mechanism, and lack of readily available abstinence resources (1–3). Prior investigations have demonstrated dose-dependent associations between alcohol misuse and poorer outcomes in patients hospitalized with pneumonia including increased risk for prolonged hospital and ICU lengths of stay and development of the acute respiratory distress syndrome (ARDS) (4–15). While changes in alcohol consumption have been consistently observed during the COVID-19 pandemic, the impact of alcohol misuse on healthcare outcomes related to COVID-19 are conflicted.…”

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confidence: 99%

Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia

Jolley

Mowry

Erlandson

et al. 2023

Critical Care Explorations

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OBJECTIVES: Alcohol misuse has been associated with increased morbidity in the setting of pulmonary infections, including the need for critical care resource utilization and development of delirium. How alcohol misuse impacts morbidity and outcomes among patients admitted with COVID-19 pneumonia is not well described. We sought to determine if alcohol misuse was associated with an increased need for critical care resources and development of delirium among patients hospitalized with COVID-19 pneumonia. DESIGN: Retrospective cohort study. SETTING: Twelve University of Colorado hospitals between March 2020 and April 2021. PATIENTS: Adults with a COVID-19 diagnosis. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: The primary outcome was admission to the ICU. Secondary outcomes included need for mechanical ventilation, development of delirium, and in-hospital mortality. Alcohol misuse was defined by International Classification of Diseases , 10th Revision codes. Of 5,979 patients hospitalized with COVID-19, 26% required ICU admission and 15.4% required mechanical ventilation. Delirium developed in 4.5% and 10.5% died during hospitalization. Alcohol misuse was identified in 4%. In analyses adjusted for age, sex, body mass index, diabetes, and liver disease, alcohol misuse was associated with increased odds of ICU admission (adjusted odds ratio [aOR], 1.46; p < 0.01), mechanical ventilation (aOR, 1.43; p = 0.03), and delirium (aOR, 5.55; p < 0.01) compared with patients without misuse. Mortality rates were not associated with alcohol misuse alone, although the presence of both alcohol misuse and in-hospital delirium significantly increased odds of in-hospital death (aOR, 2.60; p = 0.04). CONCLUSIONS: Among patients hospitalized with COVID-19, alcohol misuse was associated with increased utilization of critical care resources including ICU admission and mechanical ventilation. Delirium was an important modifiable risk factor associated with worse outcomes in hospitalized patients with alcohol misuse, including increased odds of death.

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Risk Factors of In-Hospital Mortality in Non-Specialized Tertiary Center Repurposed for Medical Care to COVID-19 Patients in Russia

Cited by 2 publications

References 63 publications

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

Differences in Dynamics of Lung Computed Tomography Patterns between Survivors and Deceased Adult Patients with COVID-19

Impact of Alcohol Misuse on Requirements for Critical Care Services and Development of Hospital Delirium in Patients With COVID-19 pneumonia

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