Risk Factors of Heterotopic Ossification Following Total Hip Arthroplasty in Patients With Ankylosing Spondylitis

Thilak, Jai; Panakkal, Jiss Joseph; Kim, Tae‐Young; Goodman, Susan M.; Lee, Sang-Soo; Salvati, Eduardo A.

doi:10.1016/j.arth.2015.06.013

Cited by 23 publications

(17 citation statements)

References 45 publications

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“…Many studies suggest that the incidence of heterotopic ossification in patients with AS after THA is higher than that of patients with arthritis after THA3132), but some studies have contradicted this outcome33). Thilak et al34) performed THA in 24 patients (47 cases) with AS, and of these, heterotopic ossification occurred in 7 cases (14.9%). Saglam et al22) carried out THA in 32 patients (59 cases) with AS from 1997 to 2012, and of these, heterotopic ossification occurred in 14 cases (13.3%).…”

Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of Cemented Total Hip Arthroplasty in Patients with Ankylosing Spondylitis at a Minimum Follow-up of 10 Years

et al. 2018

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PurposeThis study was performed to evaluate long-term clinical and radiologic outcomes of cemented total hip arthroplasty in patients with ankylosing spondylitis.Materials and MethodsA retrospective study of 12 patients (16 cases) diagnosed with ankylosing spondylitis undergoing total hip arthroplasty with cemented femoral stem from November 2002 to January 2006 with a minimum follow up of 10 years. Clinical outcomes were assessed using Harris Hip Scores and measures of pain and range of motion. Radiologic outcomes were assessed with serial plain X-ray. Fixation and stability of implant, enthesopathy of ischium and development of heterotopic ossification were also evaluated.ResultsMean Harris Hip Scores significantly improved from pre-operative levels (58 points; range, 39–81 points) to post-operative (92 points; range, 68–100 points). Mean flexion contracture levels decreased from preoperative (13°) to post-operative (5°), and mean post-operative range of motion improved 106° compared to preoperative levels. No newly developed osteolysis lesions or implant loosening were observed in last follow up X-rays. One heterotopic ossification and one greater trochanter fracture were observed. Greater trochanter fracture was treated conservatively, and was resulted in bony union. No patients underwent revisions.ConclusionThis study revealed positive long-term clinical and radiologic outcomes following total hip arthroplasty with cemented femoral stems in patients with ankylosing spondylitis patients.

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Section: Discussionmentioning

confidence: 99%

Long-term Outcomes of Cemented Total Hip Arthroplasty in Patients with Ankylosing Spondylitis at a Minimum Follow-up of 10 Years

et al. 2018

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“…[1][2][3][4][5][6][7][8][9] These contexts, normal or otherwise, share fundamental characteristics at many levels, including molecular (overexpression of bone morphogenic proteins, BMPs), cellular (a set of progenitor cells that commits to an osteoblastic lineage) and biomechanical (translation of the mechanical forces into structured and organized bone). [3,[10][11][12][13][14][15] However, there are still significant gaps in our understanding of these events and in particular few models allow long-term Bone is a dynamic tissue that remodels continuously in response to local mechanical and chemical stimuli.…”

Section: Introductionmentioning

confidence: 99%

An In Vitro Model for the Development of Mature Bone Containing an Osteocyte Network

et al. 2017

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Bone is a dynamic tissue that remodels continuously in response to local mechanical and chemical stimuli. This process can also result in maladaptive ectopic bone in response to injury, yet pathological differences at the molecular and structural levels are poorly understood. A number of in vivo models exist but can often be too complex to allow isolation of factors which may stimulate disease progression. A self‐structuring model of bone formation is presented using a fibrin gel cast between two calcium phosphate ceramic anchors. Femoral periosteal cells, seeded into these structures, deposit an ordered matrix that closely resembles mature bone in terms of chemistry (collagen:mineral ratio) and structure, which is adapted over a period of one year in culture. Raman spectroscopy and X‐ray diffraction confirm that the mineral is hydroxyapatite associated with collagen. Second‐harmonic imaging demonstrates that collagen is organized similarly to mature mouse femora. Remarkably, cells differentiated to the osteocyte phase are linked by canaliculi (as demonstrated with nano‐computed tomography) and remained viable over the full year of culture. It is demonstrated that novel drugs can prevent ossification in constructs. This model can be employed to study bone formation in an effort to encourage or prevent ossification in a range of pathologies.

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“…Two phenomena have been verified in the pathogenesis of AS: inflammation and ossification [21,22]. They are independent of each other in terms of the body’s reaction, but they are also linked to each other.…”

Section: Discussionmentioning

confidence: 99%

Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis

Zhang¹,

Ding

2016

Med Sci Monit

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BackgroundPentraxin 3 is considered to play an important role in immune and inflammatory reaction. This study aimed to detect the effect of pentraxin3 gene (PTX3) polymorphisms on ankylosing spondylitis (AS) risk.Material/MethodsThe genotyping of PTX3 polymorphisms in 101 AS patients and 93 controls was conducted by allelic discrimination assay and the genotype distribution was assessed for Hardy-Weinberg equilibrium (HWE). The differences of genotype, allele, haplotype, and some basic indexes were compared by χ2 test. Odds ratio (OR) and 95% confidence interval (95%CI) were also calculated by χ2 test and were used to evaluate the association intensity between gene polymorphisms and disease. Haploview software was used to analyze the linkage disequilibrium (LD) and haplotypes of PTX3 polymorphisms.ResultsCC genotype of rs3816527 had an obviously higher frequency in cases than in controls and had a positive effect on AS occurrence (OR=3.14, 95%CI=1.04–9.52), and the same was true of the C allele in rs3816527. For rs3845978, CT genotype showed a significant frequency difference between the case and control groups (P=0.03) and people with genotypes carrying the T allele developed AS earlier (OR=1.94, 95%CI=1.09–3.47), and the same was found in the analysis of the T allele. G-C-T haplotype dramatically increased the risk of AS, as may A-C-C haplotype.ConclusionsIn PTX3 polymorphisms rs3816527 and rs3845978 were found to be associated with AS, but rs2305619 was not.

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Risk Factors of Heterotopic Ossification Following Total Hip Arthroplasty in Patients With Ankylosing Spondylitis

Cited by 23 publications

References 45 publications

Long-term Outcomes of Cemented Total Hip Arthroplasty in Patients with Ankylosing Spondylitis at a Minimum Follow-up of 10 Years

Long-term Outcomes of Cemented Total Hip Arthroplasty in Patients with Ankylosing Spondylitis at a Minimum Follow-up of 10 Years

An In Vitro Model for the Development of Mature Bone Containing an Osteocyte Network

Association of Genetic Variants in Pentraxin 3 Gene with Ankylosing Spondylitis

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