Risk Factors of Hepatocellular Carcinoma - Current Status and Perspectives

Background: The aim of this study was to evaluate any association between a single nucleotide polymorphism (SNP) in the patatin-like phospholipase domain containing 3 (PNPLA3) (rs738409, C>G) and the development and prognosis in patients with hepatocellular carcinoma (HCC). Materials and Methods: Two hundred heathy controls and 388 HCC cases were included: 211 with HBV, 98 patients with HCV, 29 with alcoholic steatohepatitis (ASH) and 52 with non-alcoholic steatohepatitis (NASH). The SNP was determined by real-time PCR based on TaqMan assays. Results: The prevalence of rs738409 genotypes CC, CG and GG in controls was 91 (45.5%), 88 (44.0%), and 21 (10.5%), respectively, while the corresponding genotypes in all patients with HCC was 158 (40.7%), 178 (45.9%), and 52 (13.4%). The GG genotype had significantly higher distribution in patients with ASH/NASH-related HCC compared with controls (OR=2.34, 95% CI=1.16-4.71, P=0.018), and viral-related HCC cases (OR=2.15, 95% CI=1.13-4.08, P=0.020). However, the frequency of the GG genotype was similar between controls and patients with viral-related HCC. At initial diagnosis, HBV-related HCC were larger and at more advanced BCLC stage than the other HCC groups. There were no significant differences between the GG and non-GG groups regarding clinical characteristics, tumor stage and overall survival. Conclusions: These data suggest an influence of the PNPLA3 polymorphism on the occurrence of HCC in patients with ASH/NASH but not among those with chronic viral hepatitis. However, the polymorphism was not associated with the prognosis of HCC.

Section: Introductionmentioning

confidence: 99%

Association of PNPLA3 Polymorphism with Hepatocellular Carcinoma Development and Prognosis in Viral and Non-Viral Chronic Liver Diseases

Khlaiphuengsin¹,

Kiatbumrung²,

Payungporn³

et al. 2016

“…The fact that the majority of HCC patients have an underlying chronic inflammatory liver disease and liver cirrhosis is the main risk factor for HCC development (Gao et al, 2012). The chronic infection sustained by hepatitis viruses, as well as the production of cytokines and growth factors within the parenchyma and the surrounding extracellular matrix (ECM), lead to an complicated microenvironment.…”

Section: Introductionmentioning

confidence: 99%

Serum Amyloid A is a Novel Prognostic Biomarker in Hepatocellular Carcinoma

Ni¹,

Ye²,

Fu³

et al. 2015

Purpose: To investigate the prognostic value of serum amyloid A (SAA) in patients with hepatocellular carcinoma (HCC) undergoing surgery. Materials and Methods: Preoperative serum samples of 328 patients with HCC who underwent curative resection and of 47 patients with benign liver lesion were assayed. Serum levels of SAA were measured by enzyme-linked immunosorbent assay and its correlations with clinicopathological characteristics and survival were explored. Results: Levels of SAA were significantly higher in patients with HCC than those with benign liver lesion. There were strong correlations between preoperative serum SAA level and tumor size and more advanced BCLC stage. On univariate analysis, elevated SAA was associated with reduced disease-free survival and overall survival (p=0.001 and 0.03, respectively). Multivariate analyses showed that serum SAA level was an independent prognostic factor for overall survival (hazard ratio 2.80, p=0.01). Conclusions: High SAA serum level is a novel biomarker for the prognosis of HCC patients.

“…The main risk factors for HCC are chronic infection of HBV and hepatitis C virus (HCV) (Chen et al, 1997, Gao et al, 2012. Together HBV and HCV accounted for 80-90% of all HCC worldwide (Nordenstedt et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

“…HCV has been the dominant viral cause in HCC in North America, some Western countries and Japan (Nordenstedt et al, 2010). Liver cirrhosis is another most important risk factor that presented in about 80-90% of HCC patients (Nordenstedt et al, 2010, Gao et al, 2012.…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and Survival of Hepatocellular Carcinoma in North-east Peninsular Malaysia

Norsa’adah¹,

Nurhazalini-Zayani²

2013

The incidence of hepatocellular carcinoma (HCC) is relatively high in Southeast Asia. Globally, HCC has a high fatality rate and short survival. The objectives of this retrospective cohort study were to review the epidemiology and survival of HCC patients at a tertiary centre in north-east of Peninsular Malaysia. Subjects were adult HCC patients diagnosed by histopathology or radio-imaging. Secondary liver carcinoma was excluded.