Risk factors of hepatitis B virus infection between vaccinated and unvaccinated groups among spouses in 2006 and 2014: a cross-sectional study in Beijing

Guo, Yiwei; Gao, Pei; Wang, Huai; Wu, Jiang; Bai, Qian; Huang, Lieyu; Li, Shuo; Lv, Min; Shi, Xuefeng

doi:10.1080/21645515.2019.1640428

Cited by 10 publications

(10 citation statements)

References 35 publications

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“…The overall hepatitis B vaccination coverage rates in our study are similar to a report for a population of respondents from Singapore aged 25-69 years [17] and higher than that of the spouse population of Beijing in 2006 (4.59%) and 2014 (11.16%) [18]. This implies that the policy promoting hepatitis B vaccination in Beijing has achieved encouraging results.…”

Section: Discussionsupporting

confidence: 87%

Hepatitis B Vaccination Coverage Rates and Associated Factors: A Community-Based, Cross-Sectional Study Conducted in Beijing, 2019–2020

et al. 2021

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Hepatitis B vaccination coverage rates are low throughout most populations in China. Factors influencing low coverage rates, including population-specific hepatitis B vaccination barriers, may inform policies that promote vaccination. A cross-sectional survey of residents from 43 communities assessed their vaccination status and identified associated factors via uni- and multivariable logistic regression and subgroup analyses. In total, 11,280 of 36,007 respondents received a hepatitis B vaccine, indicating a 31.33% coverage rate. Multivariable logistic regression revealed non-Beijing (odds ratio (OR) = 0.81; 95% confidence interval (CI): 0.76–0.85) and residents who self-rated their health as very healthy (OR = 0.82; 95% CI: 0.68–0.99) were unlikely to be vaccinated. Farmers (OR = 1.68; 95% CI: 1.51–1.86), commerce and service workers (OR = 1.82; 95% CI, 1.63–2.04), government employees (OR = 1.56; 95% CI: 1.38–1.77), professionals and technicians (OR = 1.85; 95% CI: 1.63–2.09), and students (OR = 1.69; 95% CI: 1.10–2.59) had increased hepatitis B vaccination rates. The multivariable assessment revealed hepatitis B vaccination coverage rates are associated with confirmed or suspected family cases, vaccination unwillingness or uncertainty, and unawareness of its prevention of the hepatitis B virus. Low hepatitis B vaccination coverage rates among Beijing subpopulations highlight the need for improved strategies, including those that target specific populations.

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Section: Discussionsupporting

confidence: 87%

Hepatitis B Vaccination Coverage Rates and Associated Factors: A Community-Based, Cross-Sectional Study Conducted in Beijing, 2019–2020

et al. 2021

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“…Previous research have shown that a family history of chronic hepatitis B is evidently a risk factor for HBV infection in developing countries such as China, [14][15][16] and the prevalence of familial HBV transmission may vary depending on geographical location, history, family religious beliefs, and social customs. [17][18][19] This study based on a large-scale crosssectional household survey in Beijing was designed to analyze the current status of the hepatitis B epidemic and the risk factors associated with HBV infection and exposure among household members.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and factors associated with hepatitis B virus infection among household members: a cross-sectional study in Beijing

Xuan

Shi

et al. 2021

Human Vaccines & Immunotherapeutics

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HBV prevention and control presents a global public health priority because of the tremendous economic and healthcare burdens involved. This study was designed to investigate the status of HBV epidemics among household members, and to analyze the risk factors of HBV infection in couples and their offspring. A total of 1,035 couples and 541 offspring were included. We sourced the data from a population-based serological survey conducted by the Beijing Center for Disease Prevention and Control in 2014. Chi-square test and multiple logistic were used to assess differences in the prevalence of categorical variables, and identify risk factors for HBV infection and exposure in couples and offspring after controlling for confounding factors. In couples, the prevalence of chronic HBV infection was 4.3% and the prevalence of exposure 32.7%. The prevalence of chronic HBV infection in offspring was 0.9%, and the prevalence of exposure 8.7%. Sharing syringes with others and living with a spouse who was infected or exposed to HBV were associated with a significantly higher risk for transmission of HBV for couples. In offspring, maternal HBV infection was a significant risk factor for HBV exposure. This study provides evidence that having household members infected or exposed to HBV increases the risk of HBV transmission, and in order to achieve better control of HBV infection effective strategies must be established to prevent intra-familial transmission.

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“…Moreover, the hepatitis B vaccination rate and antibody levels of Chinese adults recruited to the HBVIDV program were higher than the levels reported in previous studies. Previous studies reported that the hepatitis B vaccine rate and antibody level of Chinese adults have been at a low level, the hepatitis B vaccination rate ranged from 17.7% to 31.2% between 2009 and 2019 [25,26,32], and the prevalence of vaccine-mediated immunity ranged from 14.2% to 34.0% between 2010 and 2014 [33][34][35][36].…”

Section: Discussionmentioning

confidence: 97%

Effect of a Community-Based Hepatitis B Virus Infection Detection Combined with Vaccination Program in China

et al. 2021

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Evidence on the effectiveness of hepatitis B virus (HBV) infection screening and vaccination programs remains rare in China. We used a quasi-experimental method, propensity score matching, to evaluate the effects of a community-based HBV infection detection combined with vaccination (HBVIDV) program in a pilot. Data were retrieved from the HBVIDV program implemented between July 2019 and June 2020. Outcomes were the difference between the treatment and control groups in hepatitis B vaccination (≥1 dose), hepatitis B vaccine series completion (≥3 doses), and serologic evidence of vaccine-mediated immunity. Altogether, 26,180 individuals were included, where 6160 (23.5%) individuals were assigned to the treatment group, and 20,020 (76.5%) individuals were assigned to the control group. After propensity score matching, 5793 individuals were matched. The rates of hepatitis B vaccination, hepatitis B vaccine series completion, and prevalence of vaccine-mediated immunity in the treatment and control groups were 29.0% vs. 17.8%, 22.1% vs. 13.1%, and 38.2% vs. 27.6%, respectively. The HBVIDV program was significantly associated with increased hepatitis B vaccination rate (OR, 1.884, 95% CI 1.725–2.057), hepatitis B vaccine series completion rate (OR, 1.872, 95% CI 1.696–2.065), and prevalence of vaccine-mediated immunity (OR, 1.623, 95% CI 1.501–1.755). The greater magnitude of association between HBVIDV program and outcomes was observed among adults aged 35–54 years and adults who live in rural areas. The HBVIDV program was effective in increasing the hepatitis B vaccination rate, hepatitis B vaccine series completion rate, and prevalence of vaccine-mediated immunity among adults in the pilot. Further focusing the program on special populations and regions may produce more effective results.

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Risk factors of hepatitis B virus infection between vaccinated and unvaccinated groups among spouses in 2006 and 2014: a cross-sectional study in Beijing

Cited by 10 publications

References 35 publications

Hepatitis B Vaccination Coverage Rates and Associated Factors: A Community-Based, Cross-Sectional Study Conducted in Beijing, 2019–2020

Hepatitis B Vaccination Coverage Rates and Associated Factors: A Community-Based, Cross-Sectional Study Conducted in Beijing, 2019–2020

Prevalence and factors associated with hepatitis B virus infection among household members: a cross-sectional study in Beijing

Effect of a Community-Based Hepatitis B Virus Infection Detection Combined with Vaccination Program in China

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