Risk factors of gestational diabetes mellitus: A hospital-based pairmatched case-control study in coastal South India

Unnikrishnan, B; Rathi, Priya; Bhat, SK; Nayak, PH; Ravishankar, Nirmala; Singh, A; Praveen, O

doi:10.7196/sajog.1625

Cited by 4 publications

(3 citation statements)

References 15 publications

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“…Critical risk of bias was found for confounding with 12 studies, 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 that did not adjust for confounding given an overall score assessment of very high risk using ROBINS-E. An additional study 15 scored very high risk due to lack of confounding variables. Ten studies were marked as high risk of bias, six 41 , 42 , 43 , 44 , 45 , 46 of which failed to control for adequate confounding variables and four 47 , 48 , 49 , 50 which failed to sufficiently define their exposure variables.…”

Section: Resultsmentioning

confidence: 99%

Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis

Dunne,

Foo,

Dachew

et al. 2024

eClinicalMedicine

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Section: Resultsmentioning

confidence: 99%

Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis

Dunne,

Foo,

Dachew

et al. 2024

eClinicalMedicine

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“…Accordingly, amassing the metformin in preparing kidney inadequacy may be relied upon to encourage lactic acidosis to ensure victims are in danger. If one rejects excess dosage of glutes, most instances about metformin-related lactic acidosis, especially deadly types, were likely unbrought about by the drug metformin [49][50][51][52][53][54][55][56][57][58].…”

Section: Lactic Acidosismentioning

confidence: 99%

A Systematic Review on Metformin

Ghosh

Kumar

Zilate

2021

JPRI

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Metformin is the primary pharmacologic treatment of type II Diabetes also the most recommended drug around the world, either alone or in blend with insulin or other glucose-lowering treatments. Metformin is a biguanide. Metformin was likewise removed because of worries over lactic acidosis, but it consequently brought down glucose levels and was once again introduced in 1995. Diabetes mellitus is a gathering of issues related to a metabolism where the glucose concentration of blood is higher than usual because of low discharge of insulin or inappropriate reactivity to insulin, bringing about hypertension. Therefore low glucose, results in cutting off intricacies. Metformin has been indicated to forestall diabetes for individuals who pose a greater danger and reduce the majority of diabetic confusion. Late responses to metformin indicated many more ramifications; for example, metformin has kidney protective characteristics. With an expanding worldwide weight of CAD, early identification and convenient administration of hazard factors are pivotal to decreasing dismalness and mortality in such patients. DM is viewed as a free danger factor for the improvement of CAD. Metformin, a drug for diabetic medication, has a role in pre-clinical and clinical examinations to lower cardiovascular occasions in DM patients. Metformin protectively affects coronary veins past its hypoglycemic impacts. Given its worldwide accessibility, course of organization, and cost, metformin gives a different restorative choice for essential and optional anticipation of CAD in DM and non-diabetics. Metformin has also shown remarkable improvements in patients with Polycystic ovarian syndrome.

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“…The study results depicted that women from rural areas and those with a monthly income ≤international normalized ratio 20,000, body mass index (BMI) >23 kg/m 2 , polyhydramnios, pregnancy-induced hypertension, oligohydramnios, and a gap between pregnancies of <2 years had a higher risk to develop GDM. 7 Exploring the risk factors of GDM, analyzing the adverse effects on pregnancy outcomes, and proposing corresponding preventive measures are of great significance for reducing the presence and progression of GDM and ensuring the safety of mothers and infants. The study aims to determine the association between maternal glycemic parameters and adverse maternal outcomes of GDM among women.…”

Section: Introductionmentioning

confidence: 99%

Glycemic Status and Maternal Outcome among Women with Gestational Diabetes Mellitus

Frank

Rodrigues

Kaipangala³

et al. 2022

Journal of Health and Allied Sciences NU

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Introduction Maternal gestational diabetes mellitus (GDM) is one of the most common medical complications of pregnancy. GDM can adversely affect the short- and long-term health of mothers and their newborns. Aim This study aims to determine the association between maternal glycemic parameters with adverse maternal outcomes and baseline characteristics among women with GDM. Settings and Design Observational, prospective study. Materials and Methods Sixty-six pregnant women visiting outpatient department of a parent hospital who were diagnosed with GDM by an obstetrician were included in the study. Glycemic parameters were documented at the time of diagnosis (at 24 weeks of pregnancy). The maternal outcomes were studied after 24 hours of delivery. Results The mean age of the women was 29.05 ± 3.98 years and 36.4% of the women were primipara. Among 66 women, 47% had a family history of diabetes mellitus, and that 48.28% of them belonged to first-degree relatives. Body mass index indicated in prepregnancy status 39.4% of them were overweight. In glycemic parameters, 63.6 and 93.9% of the women had increased fasting blood sugar and postprandial blood sugar values, respectively. Hemoglobin A1c (HbA1c) was elevated in 45.5% of the women. The maternal outcome showed that 30.30% of the women underwent cesarean section, 18.18% had preeclampsia, and 15.16% of them had increased weight gain (>11kg). There was a significant association between HbA1c and preeclampsia, p = 0.044. Conclusions The study reiterates that GDM has a poor maternal outcome, the mother is at risk to develop preeclampsia, increased maternal weight gain, and interference of cesarean section is more. Clinical Significance During the antenatal period among GDM mothers' glycemic control is very essential. Any variation in the glycemic parameters of the mother will lead to poor maternal outcomes.

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Risk factors of gestational diabetes mellitus: A hospital-based pairmatched case-control study in coastal South India

Cited by 4 publications

References 15 publications

Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis

Diabetic and hypertensive disorders following early pregnancy loss: a systematic review and meta-analysis

A Systematic Review on Metformin

Glycemic Status and Maternal Outcome among Women with Gestational Diabetes Mellitus

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