Risk factors of diabetic foot Charcot arthropathy: a case-control study at a Malaysian tertiary care centre

Fauzi, Aishah Ahmad; Chung, Tze Yang; Latif, Lydia Abdul

doi:10.11622/smedj.2016074

Cited by 37 publications

(42 citation statements)

References 24 publications

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“…Additionally, the increased blood flow may directly cause increased bone resorption by increasing the delivery of osteoclasts and monocytes resulting in greater osteoclastic activity in this area [ 15 ]. This is consistent with the finding that patients with a Charcot foot show increased blood flow to the area whereas patients with peripheral arterial disease and diabetes are relatively protected from developing the arthropathy [ 16 , 17 ].…”

Section: Pathogenesissupporting

confidence: 89%

“…Some studies reported positive correlations [ 53 – 55 ]. However, no association was found in other studies between DNOAP and a body mass index more than 25 kg/m 2 [ 7 , 16 ]. Stuck et al [ 54 ] concluded that weight loss could significantly reduce the risk of DNOAP, but might be most effective for patients with peripheral neuropathy.…”

Section: Relative Risk Factorsmentioning

confidence: 85%

“…Other studies report the most patients with DNOAP in their sixth and seventh decades [ 2 , 52 ]. Fauzi et al [ 16 ] and Nobrega et al [ 17 ] reported that age below 60 and 55 years were significant risk factors for DNOAP respectively.…”

Section: Relative Risk Factorsmentioning

confidence: 99%

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Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

et al. 2017

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Diabetic neuropathic osteoarthropathy (DNOAP) is an uncommon, but with considerable morbidity and mortality rates, complication of diabetes. The real pathogenesis is still unclear. The two popular theories are the neuro-vascular theory and neuro-traumatic theory. Most theories and pathways focused on the uncontrolled inflammations that resulted in the final common pathway, receptor activator of nuclear factor κβ ligand (RANKL)/osteoprotegerin (OPG) axis, for the decreased bone density in DNOAP with an osteoclast and osteoblast imbalance. However, the RANKL/OPG pathway does not explain all the changes, other pathways and factors also play roles. A lot of DNOAP potential relative risk factors were evaluated and reported in the literature, including age, gender, weight, duration and type of diabetes, bone mineral density, peripheral neuropathy and arterial disease, trauma history, and some others. However, most of them are still in debates. Future studies focus on the pathogenesis of DNOAP are still needed, especially for the genetic factors. And, the relationship between DNOAP and those potential relative risk factors are still need to further clarify.

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Section: Pathogenesissupporting

confidence: 89%

Section: Relative Risk Factorsmentioning

confidence: 85%

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Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

et al. 2017

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“…17 A combination of diabetic foot ulcers and the need for surgery has previously been identified as the main predictor of developing DCF in the same population of people with diabetes at the UMMC. 18 This factor had also been observed to be a strong predictor of DCF complications independent of other factors in this study. The presence of ulcers with DCF was significantly associated with amputation risk, foot surgery, development of recurrent ulcers and reduction of ambulation capability.…”

Section: Discussionsupporting

confidence: 63%

Foot ulcers and their association with diabetic Charcot foot complications

Rahman¹,

Fauzi²,

Chung³

et al. 2020

Aust J Gen Pract

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“…Diabetic nephropathy is also associated with a higher incidence of CN [ 15 ]. Trigger factors of development of the CN can also be infections (osteomyelitis precedes CN) [ 16 ] and revascularization [ 17 ]. A necessary condition for the emergence of CN is the presence of peripheral neuropathy, in particular, diabetic distal sensitive polyneuropathy.…”

Section: Methodsmentioning

confidence: 99%

Charcot Neuropathic Arthropathy of the Foot: A Literature Review and Single-Center Experience

Kucera

Shaikh

Šponer

2016

Journal of Diabetes Research

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Charcot neuropathic osteoarthropathy of the foot is a relatively common complication of diabetic neuropathy. Incorrect diagnosis and improper treatment often result in the extremity having to be amputated. This paper summarises the current view on the etiology, diagnostics, and treatment of diabetic Charcot neuropathic osteoarthropathy, with particular focus on preserving the extremity through surgical intervention from our own experiences.

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Risk factors of diabetic foot Charcot arthropathy: a case-control study at a Malaysian tertiary care centre

Cited by 37 publications

References 24 publications

Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

Pathogenesis and potential relative risk factors of diabetic neuropathic osteoarthropathy

Foot ulcers and their association with diabetic Charcot foot complications

Charcot Neuropathic Arthropathy of the Foot: A Literature Review and Single-Center Experience

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