Risk factors of congenital hydrocephalus: a 10 year retrospective study

Landingham, M Van; Nguyen, Tuan Van; Roberts, A.; Parent, Andrew D.; Zhang, Jun

doi:10.1136/jnnp.2008.148932

Cited by 41 publications

(49 citation statements)

References 37 publications

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“…23 Sexually transmitted disease at the time of delivery was associated with 1.2% of pregnancies in which the infant developed CH according to a cohort study. 27 Nevertheless, none of the identified associations were statistically significant.…”

Section: Congenital Infectionsmentioning

confidence: 95%

“…Illicit drug use was suggested as a risk factor for CH in 1 retrospective study. 27 Specifically, an association with illicit drug use was identified in 3.9% of pregnancies in which the infant developed CH; significance, nevertheless, was not reached.…”

Section: Maternal Use Of Alcohol and Illicit Drugsmentioning

confidence: 99%

“…5,27 Specifically, the complete lack of prenatal care is strongly associated with CH, 27 and initiating prenatal care after the 8th month of gestation is also related to the development of CH (OR 2.1). 5 …”

Section: Prenatal Carementioning

confidence: 99%

“…A retrospective cohort study 27 and 2 case series studies 7,25 indicated greater use of alcohol among pregnant women whose infants developed CH. Illicit drug use was suggested as a risk factor for CH in 1 retrospective study.…”

Section: Maternal Use Of Alcohol and Illicit Drugsmentioning

confidence: 99%

“…27 In a second cohort study, maternal diabetes and preeclampsia were investigated as risk factors but these associations did not reach significance. 19 Furthermore, prepregnancy obesity had a statistically significant association with CH in a meta-analysis study (OR 1.68).…”

Section: Lifestyle-modifiable Maternal Pathologiesmentioning

confidence: 99%

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Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Kalyvas

Κalamatianos

Pantazi

et al. 2016

FOC

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OBJECTIVE Congenital hydrocephalus (CH) is one of the most frequent CNS congenital malformations, representing an entity with serious pathological consequences. Although several studies have previously assessed child-related risk factors associated with CH development, there is a gap of knowledge on maternal environmental risk factors related to CH. The authors have systematically assessed extrinsic factors in the maternal environment that potentially confer an increased risk of CH development. METHODS The Cochrane Library, MEDLINE, and EMBASE were systematically searched for works published between 1966 and December 2015 to identify all relevant articles published in English. Only studies that investigated environmental risk factors concerning the mother—either during gestation or pregestationally—were included. RESULTS In total, 13 studies (5 cohorts, 3 case series, 3 case-control studies, 1 meta-analysis, and 1 case report) meeting the inclusion criteria were identified. Maternal medication or alcohol use during gestation; lifestyle modifiable maternal pathologies such as obesity, diabetes, or hypertension; lack of prenatal care; and a low socioeconomic status were identified as significant maternal environmental risk factors for CH development. Maternal infections and trauma to the mother during pregnancy have also been highlighted as potential mother-related risk factors for CH. CONCLUSIONS Congenital hydrocephalus is an important cause of serious infant health disability that can lead to health inequalities among adults. The present study identified several maternal environmental risk factors for CH, thus yielding important scientific information relevant to prevention of some CH cases. However, further research is warranted to confirm the impact of the identified factors and examine their underlying behavioral and/or biological basis, leading to the generation of suitable prevention strategies.

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Section: Congenital Infectionsmentioning

confidence: 95%

Section: Maternal Use Of Alcohol and Illicit Drugsmentioning

confidence: 99%

Section: Prenatal Carementioning

confidence: 99%

Section: Maternal Use Of Alcohol and Illicit Drugsmentioning

confidence: 99%

Section: Lifestyle-modifiable Maternal Pathologiesmentioning

confidence: 99%

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Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Kalyvas

Κalamatianos

Pantazi

et al. 2016

FOC

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Hydrocephalus

Adle‐Biassette

2018

Developmental Neuropathology

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Acculturation and selected birth defects among non‐Hispanic Blacks in a population‐based case–control study

Hoyt

Ramadhani

et al. 2020

Birth Defects Research

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Background There are noted birth defects prevalence differences between race/ethnicity groups. For instance, non‐Hispanic (NH) Black mothers are more likely to have an infant with encephalocele, although less likely to have an infant with anotia/microtia compared to NH Whites. When stratifying by nativity and years lived within the United States, additional variations become apparent. Methods Data from the National Birth Defects Prevention Study were used to calculate descriptive statistics and estimate crude/adjusted odds ratios (aORs) and 95% confidence intervals (95%CIs) among NH Blacks with one of 30 major defects and non‐malformed controls. Total case/controls were as follows: U.S.‐ (2,773/1101); Foreign‐ (343/151); African‐born (161/64). Study participants were also examined by number of years lived in the U.S. (≤5 vs. 6+ years). Results Compared to U.S.‐born, foreign‐born NH Black controls tended to be older, had more years of education, and were more likely to have a higher household income. They also had fewer previous livebirths and were less likely to be obese. In the adjusted analyses, two defect groups were significantly attenuated: limb deficiencies, aORs/95%CIs = (0.44 [0.20–0.97]) and septal defects (0.69 [0.48–0.99]). After stratifying by years lived in the United States, the risk for hydrocephaly (2.43 [1.03–5.74]) became apparent among those having lived 6+ years in the United States. When restricting to African‐born mothers, none of the findings were statistically significant. Conclusions Foreign‐born NH Blacks were at a reduced risk for a few selected defects. Results were consistent after restricting to African‐born mothers and did not change considerably when stratifying by years lived in the United States.

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Risk factors of congenital hydrocephalus: a 10 year retrospective study

Cited by 41 publications

References 37 publications

Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Maternal environmental risk factors for congenital hydrocephalus: a systematic review

Hydrocephalus

Acculturation and selected birth defects among non‐Hispanic Blacks in a population‐based case–control study

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