Risk factors in patients with macular telangiectasia 2A in an Asian population: A case–control study

Elias, Anna; Gopalakrishnan, Mahesh; Anantharaman, Giridhar

doi:10.4103/ijo.ijo_85_17

Cited by 4 publications

(4 citation statements)

References 24 publications

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“…This disease often manifests its symptoms around the sixth decade of life. According to previous research works, presenting age ranged from 39 to 86 years [3,4]. There was a female preponderance in our series (M:F -1:3) which was similar to previous studies [5][6][7][8].…”

Section: Discussionsupporting

confidence: 92%

Mactel Type 2: Evaluation of Systemic Associations and Imaging Characteristics

Manoj¹,

Sameer²,

RV³

et al. 2023

Act Sci Oph

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Purpose:The purpose of this study was to study the clinico-demographic characteristics of Mactel patients and to correlate its clinical findings with FFA and OCT findings.Methods: This prospective study was conducted in 30 Mactel patients at a tertiary eye care centre in south Kerala between May 2014 and May 2016. Clinical staging of the disease was done based on Gass and Blodi classification. In FFA, disease was classified into those with < 180 degrees leakage, > 180 degrees leakage and CNVM leakage. OCT findings were also noted. Routine blood investigations were carried out in all the patients. These were arbitrarily divided into convenient groups for the statistical analysis. Results:The mean age of MacTel patients was 57 years with a female predominance in study group. Out of this, 86.71% had overt diabetes mellitus, 36.67% had hypertension and 16.7% had familial hypercholesterolemia. Most of the patients had stage 2 disease (48.33%) while none of them had Stage 1 disease. 46.67% in the study had < 180 degrees leakage on FFA while 48.33% had > 180 degrees. 3 eyes (5%) had CNVM type of leakage. Degree of leakage on FFA tended to correlate with the stage of disease. Common OCT findings were normal OCT (43.3%), Inner Lamellar Hole in 23.33%, Outer Lamellar Hole in 15%, full thickness hole in 1.67%, foveal pigmentation in 11.67% and CNVM in 5%. However central foveal thickness did not show a correlation with vision loss. Conclusion:The coexistence of high prevalence of diabetes mellitus and hypertension was suggestive of the fact that the vascular stress in these conditions may add to the pathogenesis of Mactel. Further research is required to establish the significance of the higher prevalence of dyslipidemia in Mactel l patients as found in our study. As the disease progresses, the degree of FFA leakage seems to suggest greater disease severity. OCT characteristics, however, failed to demonstrate such a correlation. Central foveal thickness in OCT may not be a good index to correlate with visual prognosis in these patients.

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Section: Discussionsupporting

confidence: 92%

Mactel Type 2: Evaluation of Systemic Associations and Imaging Characteristics

Manoj¹,

Sameer²,

RV³

et al. 2023

Act Sci Oph

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“…Other ocular findings associated with type 2A MacTel include concurrent diabetic retinopathy, full or partial thickness macular holes, hypertension and hyperopia. 4,9,10 In our case, we discovered abnormal optic disc vascularisation in a type 2A MacTel. To the best of our knowledge, this is one of the first cases describing abnormal optic disk vascularisation with type 2A MacTel.…”

Section: Discussionsupporting

confidence: 52%

Epiretinal membrane formation and optic disc vascularisation in type 2A macular telangiectasia (MacTel)

Venkatesh,

Mangla,

Handa

et al. 2023

European Journal of Ophthalmology

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Purpose To describe a rare clinical finding of epiretinal membrane (ERM) and abnormal optic disc vascularisation in type 2A macular telangiectasia (MacTel). Case description A 52-year-old asymptomatic healthy male was examined in the retina clinic. In both eyes, corrected visual acuity was 20/20, N6. Anterior segment examination and intraocular pressure were both normal in both eyes. Results The right eye's dilated fundus examination revealed loss of retinal transparency and superficial intraretinal crystals. A thick ERM extending from the optic disc to the macula obscured the details of the underlying perifoveal region in the left eye fundus. The diagnosis of bilateral type 2 MacTel was confirmed by confocal blue reflectance imaging, fluorescein angiography (FA), and macular optical coherence tomography (OCT). The left eye macular OCT scan also revealed a thick ERM without causing significant retinal traction. Furthermore, FA of the left eye revealed early hyperfluorescence with intense late leakage at the inferior aspect of the optic disc, giving the impression of abnormal optic disc vascularisation. No other cause for the disc vascularisation could be identified. OCT scan through the area with the optic disc leakage revealed a tuft of irregular hyperreflective tissue lying over the ERM. OCT angiography imaging confirmed the vascularity within the tuft of hyperreflective tissue over the ERM. Over a two-year period, no changes in clinical or imaging features were observed. Conclusion In type 2A MacTel eyes, ERM formation and abnormal disc vascularisation are uncommon findings. More histopathologic research is needed to characterise these membranes.

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“…Patients with MacTel have a significantly higher prevalence of diabetes compared with the general population. 2,18 Nonetheless, the prevalence of DR is lower compared with diabetic patients without Mac-Tel. 3 In our cohort, the prevalence of diabetes was high, with 35% diabetic and 19% prediabetic patients, but the prevalence of DR was also low.…”

Section: Discussionmentioning

confidence: 99%